Abstract: Systems and methods to assess insulin resistance are described. Further, compounds and methods for treatment of insulin resistance or hyperglycemia are described. In some instances, immunoglobins of an individual are utilized in an insulin-stimulated mitochondrial function assay, which can be utilized to determine insulin resistance. In some instances, glycosylation, including sialylation, of immunoglobins of an individual are assessed, which can be utilized to assess insulin resistance. In some instances, immunoglobins, such as immunoglobin G, are utilized as a treatment for insulin resistance or hyperglycemia.

Abstract: An outer space-based reusable manufacturing and assembly system including at least one joint that comprises at least one receiver component, at least one strut that engages the at least one receiver component on the at least one joint and a joining element that provides for engaging and disengaging the at least one joint with at least the at least one strut so that either the at least one joint and the at least one strut are usable for another mission. Two other systems are also disclosed.

Abstract: Disclosed herein are compounds (e.g., cancer) comprising a moiety that specifically binds to oligonucleotides comprising one or more repeats of GAAA (e.g., a pyrrole/imidazole polyamide) and bromodomain inhibitor and compositions and methods thereof for use in treating proliferative diseases and disorders.

Abstract: Methods to compute gestational age and gestational health and applications thereof are described. Generally, systems utilize analyte measurements to determine a gestational age and gestational health, which can be used as a basis to perform interventions and treat individuals.

Abstract: Methods to compute gestational age and applications thereof are described. Generally, systems utilize analyte measurements derived from a urine sample to determine a gestational age, which can be used as a basis to perform interventions and treat individuals.

Abstract: Embodiments herein describe systems and methods to identify genetic silencers. Many embodiments screen one or more DNA fragments to identify sequences that are capable of silencing gene expression. Once identified, silencer elements can be utilized for many applications, including precision medicine.

Abstract: A collector device of environmental exposure is provided. This device may be used to collect and, after technical upgrade, monitor environmental exposure in personal and stationary settings. By coupling with advanced genomic analysis and chemical analysis technologies, the device and its accompanying methodology are capable of detecting environmental agents of diverse nature, many of which could pose health risks if going unaware of or uncontrolled. This type of information provides much needed clues to reconstruct and pinpoint the course of disease etiology at both personal and epidemic scales. By combining personal exposome and personal omics analyses, we can recapitulate with the intention to then prescribe treatment plans with unprecedented precision.

Abstract: A system, is disclosed having a polymer-based additive manufacturing subsystem, a metallic-based additive manufacturing subsystem, an exchanger to place at least one of the polymer-based additive manufacturing subsystem and the metallic-based additive manufacturing subsystem into a position to provide a manufacturing process, a build area where a part is created with the polymer-based additive manufacturing subsystem and the metallic-based additive manufacturing subsystem, and an environmental control unit to collect debris produced during operation of the polymer-based additive manufacturing subsystem and the metallic-based additive manufacturing subsystem. Another system and method are also disclosed.

Abstract: Systems and methods to assess metabolic dysregulation are described. Metabolic dysregulation refers to elevated glycemia or insulin resistance. The systems and methods assess metabolic dysregulation by determining which subphenotypes or underlying pathologies are contributing to the metabolic dysregulation. In some instances, a trained computational model utilizes an individual's glucose time series curve to determine the contribution of various metabolic dysregulation subphenotypes to the individual's metabolic dysregulation. Various applications or treatments can be performed based on the determination of metabolic dysregulation subphenotypes.

Abstract: Methods of treatment for menstrual complications, gestational complications, and to prolong gestation are described. Treatments include administration of a compound related to regulation of gestational progress or uterine contractions.

Abstract: A system including a plurality of space-based satellites is disclosed where each satellite has at least one of an energy capture component and an energy generator component, an energy conversion component to convert the at least one of captured energy and generated energy into a power beam for wireless transmission, and a communication system to provide for each satellite in the plurality of space-based satellites to communicate between each other. The system also includes a controller to control power beam generation from at least one satellite of the plurality of satellites. Another system and method are also disclosed.

Abstract: Classification of individuals based on their glycemic pattern and applications thereof are described. Generally, systems utilize continuous glucose monitoring data to determine glycemic pattern variability, which can be used as a basis to classify and treat individuals.

Abstract: Methods to identify modulators of histone acetyltransferases are described. Modulators of histone acetyltransferases can be used to treat individuals. In some instances, modulators of histone acetyltransferases are utilized to treat individuals having a neoplasm.

Abstract: Methods to compute gestational age and time to delivery utilizing temporal alignment methods and applications thereof are described. Generally, systems utilize analyte measurements collected at one or more time points to determine a gestational age and time to delivery, which can be used as a basis to perform interventions and treat individuals. Computational models trained utilizing temporal alignment of analyte measurements can be used to determine gestational age and time to delivery.

Abstract: An additive manufacturing device build platform is disclosed having a build area having an initial build surface, the initial build surface further having an outer area that is separable from the initial build area for use as a secondary build surface, the outer area having a rotation mechanism wherein the secondary build surface is locatable in a different plane away from the initial build surface by placement of the outer area with the rotation mechanism. Another system and method are also disclosed.

Abstract: Methods to compute gestational age and gestational health and applications thereof are described. Generally, systems utilize analyte measurements to determine a gestational age and gestational health, which can be used as a basis to perform interventions and treat individuals.

Abstract: Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.

Abstract: A system is disclosed including a robotic arm movable about a rotational axis to at least one of move and reposition a part at least one of during part creation and after part creation in a micro-gravity environment, wherein creation is performed by at least one of a polymer-based additive manufacturing subsystem and a metallic-based additive manufacturing subsystem and a gripping device attached to the robotic arm which holds the part during at least one of part creation and after part creation. Another system and method are also disclosed.

Abstract: Processes to identify a subset of trait-related genes and classify individuals are described. Generally, systems generate classification models which are used to identify the subset of trait-related genes and classify individuals. The classification models are also used in various applications, including developing research tools, performing diagnostics, and treating individuals.

Abstract: Systems and methods related to DRM content usage mechanisms for both online and offline usage of content are disclosed, including systems providing secure access to data regardless of network state or connectivity state to the networked access control mechanism. An access control mechanism having a secondary offline access control mechanism is presented, further including multiple implementations for data encapsulation, as well as providing a method for writes to files and to the filesystem itself by externally created applications with no API or modification to their operation.