Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A method and apparatus for preventing fratricide including an emitter that emits a signaling code at a wavelength, the signaling code representing a coded message; a receiver that captures an image of a field of view including the emitter and generates image information corresponding to the captured image; a translation system that: receives the image information, and decodes the coded message from the image information; and a output device that outputs the decoded message.

Abstract: A method and apparatus for preventing fratricide including an emitter that emits a signaling code at a wavelength, the signaling code representing a coded message; a receiver that captures an image of a field of view including the emitter and generates image information corresponding to the captured image; a translation system that: receives the image information, and decodes the coded message from the image information; and a output device that outputs the decoded message.

Abstract: Application of surface marking to metal stock, such as aluminum sheet, prior to or during scrap-generating manufacturing operations, to provide a detectable mark on pieces of manufacturing scrap derived from the marked sheet and commingled with scrap of other aluminum alloy sheet, so that the scrap can be sorted and the marked alloy scrap pieces separated from scrap of other alloy sheet to which the marking was not applied. Different markings, providing detectably different marks, may be respectively applied to sheet of different compositions if scrap pieces of more than two different compositions or compositional families are to be sorted and separated from each other.

Abstract: Application of surface marking to metal stock, such as aluminum sheet, prior to or during scrap-generating manufacturing operations, to provide a detectable mark on pieces of manufacturing scrap derived from the marked sheet and commingled with scrap of other aluminum alloy sheet, so that the scrap can be sorted and the marked alloy scrap pieces separated from scrap of other alloy sheet to which the marking was not applied. Different markings, providing detectably different marks, may be respectively applied to sheet of different compositions if scrap pieces of more than two different compositions or compositional families are to be sorted and separated from each other.

Abstract: A composite membrane comprises an inorganic support having interstices and porous inorganic films of sintered non-metallic particles carried by the support and bridging the interstices thereof. The support is preferably a woven metal mesh, with the films substantially coplanar with the support. The films may be formed by applying a suspension of refractory particles in a polymer solution to bridge the interstices of the support, and heating the films to partly sinter the particles. Since the films are in compression at ambient temperature, any cracks that may be formed by damage to the composite membrane tend not to propagate.

Abstract: A composite membrane comprises an inorganic support having interstices and porous inorganic films of sintered non-metallic particles carried by the support and bridging the interstices thereof. The support is preferably a woven metal mesh, with the films substantially coplanar with the support. The films may be formed by applying a suspenion of refractory particles in a polymer solution to bridge the interstices of the support, and heating the films to partly sinter the particles. Since the films are in compression at ambient temperature, any cracks that may be formed by damage to the composite membrane tend not to propagate.

Abstract: Shoe members having spaced parallel support flanges, wherein the flanges include a row of rotatably mounted wheels therebelow which are fashioned as a roller blade structure, having a pneumatic chamber within the side wall of the shoe structure of the roller blades employing a pneumatic pump bladder mounted relative to the tongue structure of the shoe to permit selective filling of the pneumatic side wall chamber.

Abstract: Porous membranes incorporating porous anodic films are disclosed. The membranes, which may be used as filters, gaseous diffusion media, dialysis membranes, etc., are produced by porous anodizing aluminum or other porous anodizable metal, creating a weakened stratum in the resulting porous anodic film (e.g. by a voltage reduction procedure during the anodizing step), attaching a support to the porous anodic film and separating the film along the weakened stratum. If the support is perforated the resulting structure is suitable as a separation device. If imperforate, the support can subsequently be perforated, if required, or replaced by a perforate support or supporting structure. The resulting structure has a non-metallic imperforate or perforated supporting layer (made, for example of plastic or ceramic) or other supporting structure, reinforcing a porous anodic film in which the pores completely penetrate the film.

Abstract: A composite membrane for microfiltration comprises a woven metal mesh support and films bridging the interstices comprising inorganic particles, e.g. zirconia, bonded together by 1-25% of an inorganic adhesive. Group IV metal e.g. Si or Zr phosphate adhesives are preferred. Low temperature film formation without sintering permits the use of non-refractory metal supports.

Abstract: A composite sheet comprises a porous inorganic membrane and a microporous inorganic film overlying a surface of the membrane, where the membrane may be an anodic aluminium oxide membrane having an average pore diameter of 5 to 100 nm, and the microporous film is of substantially uniform pore size and substantially free of cracks and pinholes. The film may be formed by applying a colloidal sol of an aluminium alkoxide, or a solution of a polymeric precursor of a titanium oxide, to a surface of the membrane to form thereon a gel layer, and drying and heating the gel to convert it to a microporous inorganic film.

Abstract: A composite sheet comprises a porous inorganic membrane and a microporous inorganic film overlying a surface of the membrane, where the membrane may be an anodic aluminum oxide membrane having an average pore diameter of 5 to 100 nm, and the microporous film is of substantially uniform pore size and substantially free of cracks and pinholes. The film may be formed by applying a colloidal sol of an aluminum alkoxide, or a solution of a polymeric precursor of a titanium oxide, to a surface of the membrane to form thereon a gel layer, and drying and heating the gel to convert it to a microporous inorganic film.

Abstract: A composite membrane comprises a porous metal support and at least one porous inorganic film of sintered non-metallic particles carried by the support and overlying a surface thereof. The film is in longitudinal compression at ambient temperature, such that any cracks tend not to propagate. The composite membranes are mechanically robust and chemically inert and useful as filters e.g. in the food industry. They may be made by applying a sol or suspension of particles to form a layer on the porous metal support and heating the coated support to partly sinter the particles of the layer.