Abstract: A method of prescribing eyewear for an individual. The method includes determining a relative retinal illuminance level for the individual and selecting, on a basis of the determined retinal illuminance level, a light transmission characteristic for eyewear lenses for the individual. At least one refractive parameter of the individual's eye is measured in order to determine the individual's retinal illuminance level.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract: The present invention relates to agonistic antibodies specifically binding human CD40, polynucleotides encoding the antibodies or antigen-binding fragments, and methods of making and using the foregoing.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract: Embodiments of the present invention relate to computer systems for transmitting or receiving and playing a plurality of data streams, where at least one of the data streams includes video data packets and/or audio data packets and at least one other data stream includes further data packets that are synchronized with the video and/or audio data packets. In particular embodiments, the further data stream includes haptic data packets that include haptic command data generated in real time with the video and/or audio data streams, where the haptic command data is provided to a haptic output device configured to replicate or approximate sensations through the output of one or more mechanical forces in synchronization with the playing of video and/or audio from the video and/or audio data streams.

Abstract: An instrument for cleaning canals during endodontic procedures is presented. The instrument is formed in one piece from a stiff polymeric material. The instrument features a handle, a measuring shaft, and a tapering shank with raised polymeric projections along its length. The present invention is designed without the use of bristles that conventional brushes contain. The raised polymeric projections include fins that may be oriented parallel to or transverse to the axis of the instrument to provide multidirectional cleaning capability. The instrument is stiff enough to penetrate a canal and mechanically scrub and scrape canal surfaces, but flexible enough to negotiate the curves of the canal.

Abstract: The present disclosure provides a method for enhancing the anti-tumor efficacy of an Fc fusion protein which binds specifically to a target, e.g., a co-inhibitory or co-stimulatory receptor of ligand, on a T cell in a subject afflicted with a cancer or a disease caused by an infectious agent and alters the activity of the immunomodulatory target, thereby potentiating an endogenous immune response against cells of the cancer or the infectious agent, wherein the method comprises selecting, designing or modifying the Fc region of the Fc fusion protein so as to enhance the binding of said Fc region to an activating Fc receptor (FcR). The disclosure also provides an Fc fusion protein produced by said method which has an enhanced ability to potentiate an endogenous immune response against cells of a cancer or an infectious agent in a subject.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for providing an enhanced media presentation. In one embodiment, an enhanced media presentation is provided. To provide the enhanced media presentation, one or more content items associated with subject matter associated with a segment of an enhanced media presentation are identified. Each content item may be associated with at least one uniform resource identifier. Then, a content object based at least in part on at least one content item is created. The content object is an abstract representation of the content item. The content object can be associated with the segment and provided for simultaneous displayed simultaneously with at least a portion of the segment.

Abstract: An instrument for cleaning canals during endodontic procedures is presented. The instrument is formed in one piece from a stiff polymeric material. The instrument features a handle, a measuring shaft, and a tapering shank with raised polymeric projections along its length. The present invention is designed without the use of bristles that conventional brushes contain. The raised polymeric projections include fins that may be oriented parallel to or transverse to the axis of the instrument to provide multidirectional cleaning capability. The instrument is stiff enough to penetrate a canal and mechanically scrub and scrape canal surfaces, but flexible enough to negotiate the curves of the canal.

Abstract: A vehicle operator interface system and method for a diesel particulate filter regeneration system, includes a control unit for receiving information on regeneration status of a vehicle diesel particulate filter and receiving information on operational status of selected vehicle systems and components, a visual display for displaying messages to an operator indicative of said regeneration status and said operational status, an input device for highlighting a portion of the displayed messages and for providing an input selection of a highlighted portion, an input selection being communicated to a control device to carry out the input selection.

Abstract: A conical dental bur for endodontic procedures, including exploration, deep troughing, enlargement of orifices, and canal navigation is presented. The bur of the present invention has a narrow, conical bur head with cutting members along its length. The head of the bur of the present invention is mounted to a shank that tapers to the bur head, allowing microscopic observations of endodontic procedures. The bur may be manufactured of tungsten carbide, diamond, ceramics, or other materials. Burs according to the present invention of various shapes and sizes, suited for particular procedures, may be packaged together in kits. Methods of using the burs in endodontic procedures are also disclosed.

Abstract: An example approach is provided for generating and managing service requests. One or more service requests are generated. Further, the one or more requests are assigned to one or more service providers and are aggregated. Furthermore, one or more updates are presented on at least a portion of the aggregation.