Abstract: A method for preparing an abradable panel for a rub strip of a fan case of a gas turbine engine includes forming an abradable material into a plurality of panels each comprising an abradable structure; curing the abradable material in the plurality of panels; and installing the plurality of panels into the fan case. The panels can be cured and assembled into a fully assembled rubstrip, and then the assembled rubstrip can be installed into the fan case.

Abstract: An abradable material for a rub strip of a gas turbine engine component includes a polymer matrix, and an organic or inorganic filler distributed through the matrix, wherein the abradable material has a compression spring rate profile including: less than 50,000 lb/in at ?65° F., less than 35,000 lb/in at room temperature, and less than 35,000 lb/in at 200° F.

Abstract: A system may have a support structure that separates an exterior region from an interior region. The system may include a lighting system with interior and/or exterior lights with adjustable diffusers. An interior light may be used as a task light, a cabin light, a sensor indicator light, or a trim light. Adjustments to the adjustable diffusers can be used to adjust the angular spread of emitted light for operation in different lighting modes.

Abstract: Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of MARK are provided.

Abstract: Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.

Abstract: Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.

Abstract: Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.

Abstract: Drosophila melanogaster and C. elegans that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living nematodes using fluorescently-labelled fatty acid conjugates, such BODITY™ fatty acid conjugates, are also described. Novel SREBP pathway nucleic acid and protein sequences are also described.

Abstract: The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein.