Abstract: The invention relates to methods for inhibiting gene silencing, methods for inhibiting cell proliferation, methods for inhibiting Ras mediated tumor growth, methods for screening for regulators of FAS expression, and methods for identifying inhibitors of Ras mediated tumor growth.

Abstract: Various regulatory domains promulgate standards to define how wireless devices should operate in certain frequency bands. The 5 GHz spectrum is of particular importance to certain regulatory domains because of radar systems also operating in this spectrum. To avoid interference with such radar systems, wireless devices operating in this spectrum should be able to detect radar and quickly vacate any channels currently used by the radar systems. Techniques are provided for performing startup scans for radar, identifying backup channels for a possible channel switch, and efficiently changing channels in the event of radar detection in the operating channel. These techniques advantageously meet current regulatory standards governing DFS while minimizing network startup delays and disruption to users during a radar event.

Abstract: A set of global location signals, an SBAS (Satellite Based Augmentation System), or an ACI (ambient country identifier) signal can be used to automatically provide location awareness for a WLAN device. If one of the set of global location signals, the SBAS signal, or the ACI signal is detected, then the WLAN device can configure itself to comply with channel and power settings for the country/region having the detected signal(s). After configuration, the WLAN device can be “locked” to the country/region having the signal(s), thereby ensuring legal operation of the WLAN device even after subsequent restarts. If one of the signals is not detected, then the WLAN device can be configured in a default mode, e.g. an “open mode” in which end users can configure the WLAN device by entering a country of operation or a “common mode” in which the channel and transmit power settings meet global spectrum usage requirements.

Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.

Abstract: An ambient country identifier (ACI) signal can be used to automatically provide location awareness for a WLAN device. If an ACI signal is detected, then the WLAN device can configure itself to comply with channel and power settings for the country having the detected ACI signal. After detection of the ACI signal, the WLAN device can be “locked” to the country having that ACI signal, thereby ensuring legal operation of the WLAN device even after subsequent restarts. If an ACI signal is not detected, then the WLAN device can be configured in a default mode, e.g. an “open mode” in which end users can configure the WLAN device by entering a country of operation or a “common mode” in which the channel and transmit power settings meet global spectrum usage requirements.

Abstract: An ambient country identifier (ACI) signal can be used to automatically provide location awareness for a WLAN device. If an ACI signal is detected, then the WLAN device can configure itself to comply with channel and power settings for the country having the detected ACI signal. After detection of the ACI signal, the WLAN device can be “locked” to the country having that ACI signal, thereby ensuring legal operation of the WLAN device even after subsequent restarts. If an ACI signal is not detected, then the WLAN device can be configured in a default mode, e.g. an “open mode” in which end users can configure the WLAN device by entering a country of operation or a “common mode” in which the channel and transmit power settings meet global spectrum usage requirements.

Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.

Abstract: An antenna is provided with an electronic component or circuit that has a value corresponding to properties of the antenna. A read mechanism reads the value and sets an operational status of a transceiver based on the value. In one embodiment, electronic component is a resistor having a value that identifies the antenna properties. A table may be used to correlate resistor values to different types of antennas or sets of antenna properties. Alternatively, the circuit can be embodied in a microchip that provides a response to a challenge sent by the read mechanism. The response encodes the properties of the antenna. The encoding scheme includes values from the challenge. Alternatively, the response is a code that is indexed into a table of antenna properties. In one embodiment, the antenna is connectorized.

Abstract: Various regulatory domains promulgate standards to define how wireless devices should operate in certain frequency bands. The 5 GHz spectrum is of particular importance to certain regulatory domains because of radar systems also operating in this spectrum. To avoid interference with such radar systems, wireless devices operating in this spectrum should be able to detect radar and quickly vacate any channels currently used by the radar systems. In a channel switching technique, if the new channel is radar-exempt, then normal operation commences on the new channel. If the new channel is non-radar-exempt, then normal operation commences on a temporary radar-exempt channel and an aggregate background scan can be performed on the new channel. If no radars are detected using the aggregate background scan, then operation is switched from the temporary radar-exempt channel to the new channel. This channel switching technique minimizes disruption to users during a radar event.

Abstract: An antenna is provided with an electronic component or circuit that has a value corresponding to properties of the antenna. A read mechanism reads the value and sets an operational status of a transceiver based on the value. In one embodiment, electronic component is a resistor having a value that identifies the antenna properties. A table may be used to correlate resistor values to different types of antennas or sets of antenna properties. Alternatively, the circuit can be embodied in a microchip that provides a response to a challenge sent by the read mechanism. The response encodes the properties of the antenna. The encoding scheme includes values from the challenge. Alternatively, the response is a code that is indexed into a table of antenna properties. In one embodiment, the antenna is connectorized.

Abstract: Methods for controlling expression of a gene in a living cell are disclosed. In general, the methods include contacting the 5′untranslated region (5′ UTR) of an RNA in the cell with a cell permeable, small molecule. In some embodiments of the invention, the method includes providing an aptamer that binds specifically to the cell permeable, small molecule; incorporating the aptamer into a region of a gene, which region encodes a 5′ UTR of an RNA; and contacting the cell-permeable, small molecule with a cell that contains the gene. The cell-permeable, small molecule enters the cell and binds specifically to the aptamer sequence in the 5′ UTR of RNA molecules transcribed from the gene. This binding specifically inhibits translation of the RNA molecules to which the cell permeable, small molecule is bound, thereby controlling expression of the gene.

Abstract: Various regulatory domains promulgate standards to define how wireless devices should operate in certain frequency bands. The 5 GHz spectrum is of particular importance to certain regulatory domains because of radar systems also operating in this spectrum. To avoid interference with such radar systems, wireless devices operating in this spectrum should be able to detect radar and quickly vacate any channels currently used by the radar systems. In a channel switching technique, if the new channel is radar-exempt, then normal operation commences on the new channel. If the new channel is non-radar-exempt, then normal operation commences on a temporary radar-exempt channel and an aggregate background scan can be performed on the new channel. If no radars are detected using the aggregate background scan, then operation is switched from the temporary radar-exempt channel to the new channel. This channel switching technique minimizes disruption to users during a radar event.

Abstract: Various regulatory domains promulgate standards to define how wireless devices should operate in certain frequency bands. The 5 GHz spectrum is of particular importance to certain regulatory domains because of radar systems also operating in this spectrum. To avoid interference with such radar systems, wireless devices operating in this spectrum should be able to detect radar and quickly vacate any channels currently used by the radar systems. Techniques are provided for performing startup scans for radar, identifying backup channels for a possible channel switch, and efficiently changing channels in the event of radar detection in the operating channel. These techniques advantageously meet current regulatory standards governing DFS while minimizing network startup delays and disruption to users during a radar event.

Abstract: A computer system for the closed-loop support of patient self-testing includes data repository, healthcare provider interface, training interface, supplier, patient interface and analysis modules. The data repository module is configured to store patient enrollment and patient self-test information. The healthcare provider interface module is configured to receive patient enrollment and modified patient prescription information furnished by a healthcare provider and to transfer these to the data repository module. The healthcare provider interface module is also configured to communicate patient self-test result information to a healthcare provider. The training module is configured to receive patient diagnostic monitoring device training information and to transfer that information to the data repository module.

Abstract: Methods for controlling expression of a gene in a living cell are disclosed. In general, the methods include contacting the 5′untranslated region (5′ UTR) of an RNA in the cell with a cell permeable, small molecule. In some embodiments of the invention, the method includes providing an aptamer that binds specifically to the cell permeable, small molecule; incorporating the aptamer into a region of a gene, which region encodes a 5′ UTR of an RNA; and contacting the cell-permeable, small molecule with a cell that contains the gene. The cell-permeable, small molecule enters the cell and binds specifically to the aptamer sequence in the 5′ UTR of RNA molecules transcribed from the gene. This binding specifically inhibits translation of the RNA molecules to which the cell permeable, small molecule is bound, thereby controlling expression of the gene.

Abstract: A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.

Abstract: Methods for controlling expression of a gene in a living cell are disclosed. In general, the methods include contacting the 5′ untranslated region (5′ UTR) of an RNA in the cell with a cell permeable, small molecule. In some embodiments of the invention, the method includes providing an aptamer that binds specifically to the cell permeable, small molecule; incorporating the aptamer into a region of a gene, which region encodes a 5′ UTR of an RNA; and contacting the cell-permeable, small molecule with a cell that contains the gene. The cell-permeable, small molecule enters the cell and binds specifically to the aptamer sequence in the 5′ UTR of RNA molecules transcribed from the gene. This binding specifically inhibits translation of the RNA molecules to which the cell permeable, small molecule is bound, thereby controlling expression of the gene.

Abstract: Disclosed is a method for screening for inhibitors of Hepatitis B Virus pX activity. The method involves contacting a test compound with (I) the pX protein of HBV, (ii) a transcription factor comprising the bZIP domain, or fragments that comprise a minimal a bZIP domain, and (iii) an oligoduplex comprising a target DNA sequence of the transcription factor to form a test mixture. After incubating the test mixture under appropriate conditions and for a sufficient time to allow pX-mediated dimerization and DNA binding of the transcription factor to occur, the level of DNA binding of the transcription factor in each test mixture is determined. A test compound is considered to be any compound that causes a decrease in the level of DNA binding in the test mixture relative to the level of DNA binding in control mixtures.

Abstract: Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis?4-(2-N,N-dimethylaminopropylamidino)phenyl!furan.

Abstract: The present invention provides a human cellular polypeptide, termed hRIP, that is necessary for HIV replication. The polypeptide has a molecular mass of about 59 kDa, having the sequence set forth in FIG. 2a (SEQ ID NO:1). hRIP is the cellular cofactor required to mediate the Rev response. hRIP binds HIV Rev protein and is essential for Rev activity. The invention also includes nucleic acid sequences encoding hRIP, as well as DNA vectors and transformed cells suitable for recombinant expression of this polypeptide.