Abstract: A method and system for performing diagnostics or software maintenance on a vehicle comprises recording high-fidelity data at the vehicle consistent with configuration files to support engineering analysis or diagnostics on vehicle components, systems or performance. Supplemental data is retrieved via a low bandwidth transmission at the vehicle to supplement the recorded high-fidelity data. The recorded high-fidelity data and retrieved supplemental data is processed to generate a diagnostic status report message from transmission to the central electronic data processing system. A data processor or central electronic data processing system organizes the diagnostic report message, the recorded high fidelity data and the retrieved supplemental data into a data mart or diagnostics database to support engineering analysis or diagnostics on vehicle components, systems or performance.

Abstract: The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.

Abstract: Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.

Abstract: An aerosol preparation assembly includes an entrainment chamber defining an entrainment volume. The entrainment chamber includes a gas inlet port, an aerosol inlet port and an outlet port. The entrainment chamber is configured such that a velocity of a flow of a gas within the entrainment volume is less than a velocity of the flow of the gas within the gas inlet port. The entrainment chamber is configured such that at least a portion of inlet aerosol is entrained into the flow of the gas within the entrainment volume to produce an entrained aerosol flow at the outlet port. The particle selection chamber is configured to receive the entrained aerosol flow and produce an outlet aerosol flow. The particle selection chamber and nozzle are collectively configured such that a volumetric median diameter of the outlet aerosol flow is less than a volumetric median diameter of the inlet aerosol.

Abstract: This invention relates to sodium channel blocking phenyl guanidine compounds of Formula (I): pharmaceutical compositions comprising them, and methods of using them for blocking sodium channels, promoting hydration of mucosal surfaces, and for methods of treating diseases including cystic fibrosis, COPD, asthma, emphysema, chronic bronchitis, and pneumonia.

Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

Abstract: This invention provides compounds of the formula I: and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.

Abstract: The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.

Abstract: A method for performing diagnostics or software maintenance on a vehicle comprises storing components of configuration files in a central processing system. An update of the configuration files is requested for the vehicle from a central electronic data processing system based on a user request. The requested update of components of configuration files are received from the central electronic data processing system based on a comparison of a record of the vehicle-installed configuration files and target configuration information on configuration files stored at the central electronic data processing system.

Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

Abstract: Systems and methods of providing comprehensive pharmaceutical consultations are disclosed, including generating a consultation recording block corresponding to a filling of a prescription order for a patient. The consultation recording block may include multiple consultation entries, where each consultation entry corresponds to a particular pharmaceutical consultation that is desired or required to occur in conjunction with the prescription fill. Input corresponding to various fields of various consultation entries may be received and stored. Different fields of different consultation entries corresponding to a particular patient and to a particular prescription order may be displayed, populated, viewed, resolved and authorized by different pharmaceutical personnel at different work flow stages of the filling, and in some cases, one or more consultation entries may be automatically generated and at least partially automatically populated.

Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

Abstract: Systems and methods of determining pharmaceutical consultation compliance are disclosed, including generating and storing a plurality of consultation recording blocks corresponding to fillings of prescription orders for patients. The consultation recording blocks may include multiple consultation entries, where each consultation entry corresponds to a particular pharmaceutical consultation that is desired or required to occur in conjunction with a prescription fill for a particular patient. The consultation entries may be populated in conjunction with respective filling of prescription orders and work flow stages therein, or on demand. A request for pharmaceutical consultation compliance may be received, and a response to the request may be determined based on information from at least some portions of the consultation entries, such as a status portion, an authorization portion and/or other portions.

Abstract: In one embodiment, a method for determining concept attributes for a concept term includes receiving a concept term and determining one or more word senses for the concept term. A word sense is selected from the one or more word senses, and, based on the selected word sense, one or more conceptually similar terms for the concept term is determined. The method also includes determining that at least one of the one or more conceptually similar terms is a concept attribute for the concept term and generating a mapping to associate the concept attribute with the concept term. The mapping is stored in an onomasticon.

Abstract: A system and method for control of water content in a strip bath. The method to control water content in a solvent bath used for cleaning of semiconductor parts in the back end of semiconductor manufacturing requires addition of water to replace evaporated water. This is done by periodically adjusting a conductivity setpoint at least in part based on the elapsed chemical bathlife and at least in part based on the number of semiconductor parts that have been processed in the bath. The conductivity of the strip bath solution is then continuously measured (as by using an electrodeless conductivity probe). Water is added (as by a DI water injection system) into the bath solution whenever the solvent conductivity falls below the conductivity set point.

Abstract: Provided is a method of treating cystic fibrosis in which an effective amount of a compound represented by formula (I) is administered to a subject in need thereof: where the structural variables are as defined herein.

Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

Abstract: In one embodiment, searching documents includes generating a query conceptual graph for a search query. The query conceptual graph has graph terms representing concept types. A set of conceptually similar terms is identified for each graph term, and the set is mapped to the concept type represented by the graph term. Documents are searched in accordance with the set of conceptually similar terms. In another embodiment, selecting a document includes determining documents that satisfy a search query expressed as a query conceptual graph. A document conceptual graph that has graph terms representing concept types is generated for each document. A set of conceptually similar terms is identified for each graph term, where the set is mapped to the concept type represented by the graph term. A document is selected if terms of the sets associated with the document match terms associated with the query conceptual graph.

Abstract: Provided are compounds represented by the formula: where the structural variables are as defined herein. The compounds function as sodium channel blockers and my be used for promoting hydration of mucosal surfaces.

Abstract: Embodiments of a pyrotechnically-gimbaled targeting unit are provided. In one embodiment, the targeting unit includes a targeting unit housing, a countermeasure payload carried by the targeting unit housing, and a plurality of thrusters coupled to the targeting unit housing. The plurality of thrusters is configured to be selectively activated to rotate the targeting unit housing about first and second substantially orthogonal axes to provide controlled pointing of countermeasure payload prior to the deployment thereof. Embodiments of a countermeasure system including a pyrotechnically-gimbaled targeting unit are also provided, as are methods for equipping a vehicle with a countermeasure system of the type that includes at least one pyrotechnically-gimbaled targeting unit.