Patents by Inventor Michael R. Karl

Michael R. Karl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioconversions catalysed by the toluene monooxygenase of Pseudomonas mendocinaKR-1
    Patent number: 5605823
    Abstract: Disclosed and claimed are toluene monooxygenase (TMO) gene sequences from Pseudomonas mendocina KR-1, TMO proteins encoded by these sequences, recombinant plasmids containing such sequences, and microorganism host cells containing such plasmids. A five-gene and six-gene TMO gene cluster encode proteins that are useful in a variety of bioconversions. In particular, the TMO gene cluster is useful fort he preparation of p-hydroxyphenylacetic acid and indigo. In addition, the TMO gene cluster is useful for the degradative bioconversion of toxic compounds, such as trichloroethylene.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: February 25, 1997
    Assignee: Amgen Inc.
    Inventors: Kwang-Mu Yen, Lawrence M. Blatt, Michael R. Karl
  • Bioconversions catalyzed by the toluene monooxygenase of Pseudomanas mendocina KR-1
    Patent number: 5171684
    Abstract: Disclosed and claimed are toluene monooxygenase (TMO) gene sequences from Pseudomonas mendocina KR-1, TMO proteins encoded by these sequences, recombinant plasmids containing such sequences, and microorganism host cells containing such plasmids. A five-gene and six-gene TMO gene cluster encode proteins that are useful in a variety of bioconversions. In particular, the TMO gene cluster is useful for the preparation of p-hydroxyphenylacetic acid and indigo. In addition, the TMO gene cluster is useful for the degradative bioconversion of toxic compounds, such as trichloroethylene.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: December 15, 1992
    Assignee: Amgen Inc.
    Inventors: Kwang-Mu Yen, Lawrence M. Blatt, Michael R. Karl