Abstract: Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells. In particular, compounds that exhibit inhibitory activity upon 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzymes and their use in the treatment of cancer and/or parasitic diseases are provided.

Abstract: Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells.

Abstract: A gauge adaptor apparatus allows easy connection and removal of a gauge to a hydronic system or other fluidic piping system for taking a pressure or temperature reading. The gauge adaptor apparatus is compatible with standard hose connections and can be used to quickly and easily add a gauge onto a hydronic system without requiring extensive labor and without needing to halt the operation of the system. Gauge adaptor apparatuses can be used to take one-time readings, or they can be left permanently installed for ongoing readings of the system. Gauge adaptor apparatuses take up little space, are highly compatible with existing fluid valves and system configurations, can be installed quickly and easily without requiring much labor, and can be easily removed for system draining, servicing, or replacement.

Abstract: A gauge adaptor apparatus allows easy connection and removal of a gauge to a hydronic system or other fluidic piping system for taking a pressure or temperature reading. The gauge adaptor apparatus is compatible with standard hose connections and can be used to quickly and easily add a gauge onto a hydronic system without requiring extensive labor and without needing to halt the operation of the system. Gauge adaptor apparatuses can be used to take one-time readings, or they can be left permanently installed for ongoing readings of the system. Gauge adaptor apparatuses take up little space, are highly compatible with existing fluid valves and system configurations, can be installed quickly and easily without requiring much labor, and can be easily removed for system draining, servicing, or replacement.

Abstract: The present invention relates to a method of producing a recombinant protein by harvesting a microbial cell broth and adding an amount of a flocculant to achieve an effective particle size distribution. The present invention also relates to a method of clarifying a microbial harvest by adding an amount of a flocculant to achieve an effective particle size distribution.

Abstract: A boiler loop system including a primary-secondary piping loop interface apparatus including a flow diversion device, and a drain valve, and a drain port in branches from a circumferential sidewall. In an embodiment, supply branch piping and return branch piping connect the primary-secondary piping loop interface apparatus to a boiler and provide attachment points for auxiliary plumbing equipment. In an embodiment, the boiler loop is integrated into the primary loop.

Abstract: A boiler loop system including a primary-secondary piping loop interface apparatus having unitary construction including a flow diversion device, and a drain valve and a drain port in branches from a circumferential sidewall. In an embodiment, supply branch piping and return branch piping connect the primary-secondary piping loop interface apparatus to a boiler and provide attachment points for auxiliary plumbing equipment. In an embodiment, the boiler loop is integrated into the primary loop.

Abstract: A near-boiler piping loop apparatus is provided including a primary/secondary piping loop interface apparatus having a unitary construction including a secondary loop shut-off valve, drain valve and drain port in each branch of a secondary loop for connection to a boiler. Supply branch piping and return branch piping connects the interface apparatus to the boiler and provides attachment points for auxiliary plumbing equipment. The apparatus is adapted to connect to pump in variable orientations using rotatable flanges on the interface apparatus and on a wye strainer in the secondary loop supply branch and includes a union fitting attached to the interface apparatus. The union fitting provides a mounting hole for a temperature or pressure gauge.

Abstract: A primary-secondary loop piping system includes at least one boiler in fluid communication with a primary piping loop and at least one primary loop pump in the primary piping loop. At least one secondary piping loop branches away from the primary loop and returns downstream to the primary loop via a pair of closely spaced tees in a primary/secondary piping loop interface apparatus. The primary/secondary piping loop interface apparatus is of unitary construction and includes a secondary loop shut-off valve, drain valve and drain port in each branch of each secondary loop in which it is installed.

Abstract: A primary-secondary loop piping system includes at least one boiler in fluid communication with a primary piping loop and at least one primary loop pump in the primary piping loop. At least one secondary piping loop branches away from the primary loop and returns downstream to the primary loop via a pair of closely spaced tees in a primary/secondary piping loop interface apparatus. The primary/secondary piping loop interface apparatus is of unitary construction and includes a secondary loop shut-off valve, drain valve and drain port in each branch of each secondary loop in which it is installed.

Abstract: A near-boiler piping loop apparatus is provided including a primary/secondary piping loop interface apparatus having a unitary construction including a secondary loop shut-off valve, drain valve and drain port in each branch of a secondary loop for connection to a boiler. Supply branch piping and return branch piping connects the interface apparatus to the boiler and provides attachment points for auxiliary plumbing equipment. The apparatus is adapted to connect to pump in variable orientations using rotatable flanges on the interface apparatus and on a wye strainer in the secondary loop supply branch and includes a union fitting attached to the interface apparatus. The union fitting provides a mounting hole for a temperature or pressure gauge.

Abstract: A primary/secondary loop adapter comprising a valve body having a first primary loop port, a second primary loop port, a first secondary loop port and a second secondary loop port is provided. The secondary loop ports are disposed at respective ends or a linear secondary loop portion of the valve body. A primary loop portion of the valve body is formed by a pair of closely spaced tees extending from the secondary loop portion. At least one main valve portion is disposed in a first one of the tees. A drain/venting valve portion may extend from one or more of the main valve portions. One or both of the primary loop ports may include a flange for connecting to an apparatus in the primary loop.

Abstract: This invention comprises a purge valve comprising a valve body having a first primary loop port and a second primary loop port, the valve body defining a first secondary loop port and second secondary loop port, the valve body defining a flow channel and a valve portion, the valve portion in communication with the first, second, third, and forth port and a flow diversion device disposed within the valve portion, the flow diversion device configurable between a first and second position such that when the flow diversion device is in the first position the first primary loop port is in communication with the second primary loop port, the first secondary loop port and the second secondary loop port and when the flow diversion device is in a second position the first primary loop port is in communication with the first secondary loop port only and the second primary loop port is in communication with the second secondary loop port only.

Abstract: This invention comprises a purge valve comprising a valve body having a first primary loop port and a second primary loop port, the valve body defining a first secondary loop port and second secondary loop port, the valve body defining a flow channel and a valve portion, the valve portion in communication with the first, second, third, and forth port and a flow diversion device disposed within the valve portion, the flow diversion device configurable between a first and second position such that when the flow diversion device is in the first position the first primary loop port is in communication with the second primary loop port, the first secondary loop port and the second secondary loop port and when the flow diversion device is in a second position the first primary loop port is in communication with the first secondary loop port only and the second primary loop port is in communication with the second secondary loop port only.

Abstract: A fluid isolation valve having a valve body with a first fluid flow port, a second fluid flow port and a fluid drain port with a valve in the fluid drain port. The valve body also defines a fluid flow channel, a drain flow channel and a valve portion, wherein the valve portion is disposed in the valve body to be communicated with the first fluid flow port, the second fluid flow port and the fluid drain port A flow diversion device is also provided and is disposed within the valve portion. The flow diversion device is configurable between a first configuration and a second configuration, such that when the flow diversion device is in the first configuration the first fluid flow port is communicated with the second fluid flow port Consequently, when the flow diversion device is in the second configuration the first fluid flow port is communicated with the fluid drain port. The fluid flow can be decrease or stop by use of the valve within the fluid drain port.

Abstract: A fluid isolation valve having a valve body with a first fluid flow port, a second fluid flow port and a fluid drain port with a valve in the fluid drain port. The valve body also defines a fluid flow channel, a drain flow channel and a valve portion, wherein the valve portion is disposed in the valve body to be communicated with the first fluid flow port, the second fluid flow port and the fluid drain port. A flow diversion device is also provided and is disposed within the valve portion. The flow diversion device is configurable between a first configuration and a second configuration, such that when the flow diversion device is in the first configuration the first fluid flow port is communicated with the second fluid flow port. Consequently, when the flow diversion device is in the second configuration the first fluid flow port is communicated with the fluid drain port. The fluid flow can be decrease or stop by use of the valve within the fluid drain port.