Abstract: A real-time system and method for invoking a fraud alert notification to a bank prompted by an abandoned deposit following a denied accelerated funding request for a financial item.

Abstract: Loss reduction methods are described. A first transmission loss associated with signal transmission through a trace in a first circuit board design is determined. The trace is routed from an integrated circuit disposed on a circuit board to a circuit element disposed on the circuit board. It is determined that the first transmission loss is greater than a threshold transmission loss. The first circuit board design is altered to obtain a second circuit board design. In the second circuit board design, the trace is routed from the integrated circuit to a connector disposed on the circuit board, and the connector is electrically coupled to the circuit element by a cable. A second transmission loss associated with signal transmission between the integrated circuit and the circuit element in the second circuit board design is less than the threshold transmission loss.

Abstract: A circuit system includes a circuit board. An integrated circuit is mounted on the circuit board, the integrated circuit including a plurality of pins. A trace-to-cable connector is mounted on the circuit board, the trace-to-cable connector configured to couple to a first cable of a first cable-type. A cable-to-cable connector is mounted on the circuit board, the cable-to-cable connector configured to couple the first cable to a second cable of a second cable-type. A first plurality of metal traces couple a first subset of the plurality of pins to the trace-to-cable connector.

Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.

Abstract: Anti-SIRP? antibodies, including multi-specific anti-SIRP? antibodies, are provided, as are related compositions and methods. The antibodies of the disclosure bind to SIRP? and can block the interaction of CD47 on one cell with SIRP? on a phagocytic cell. The subject anti-SIRP? antibodies find use in various therapeutic methods. Embodiments of the disclosure include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the anti-SIRP? antibodies; and cell lines that produce the antibodies. Also provided are amino acid sequences of exemplary anti-SIRP? antibodies.

Abstract: A cushioning apparatus for a railway car employs a shortened yoke having a draft gear housing integral with the yoke. A stack elastomeric pads is provided in the housing, and a second stack of elastomeric pads and corresponding rigid metal plates, is positioned in the sill behind the modified yoke to absorb buff loads on the coupler. In embodiments, the entire assembly may be placed in a sill having forward stops, intermediate stops, and rear stops.

Abstract: Power demands of a computing system, such as a network device and/or a component thereof, are stabilized by introducing a programmable delay into identical or substantially similar subsystems within an integrated circuit. Each subsystem reads a potentially different delay value from an associated storage, memory, or input, and waits for some time indicated by the delay value before beginning execution. For example, in a group of identical subsystems that process data concurrently, some or all of the subsystems begin processing their respective data after a different amount of delay, thus staggering their respective executions and lowering the risk of aligned edges when some or all of the subsystems concurrently step their power demands up or down. This, in turn, reduces peak power and voltage. In an embodiment, rather than being fixed at the design stage, each subsystem's delay value is programmable at some point after fabrication.

Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients.

Abstract: A yoke for a railway car is provided with a coupler support protruding from a top wall of the yoke into an interior space in the yoke to contact the coupler shank when the coupler head is deflected downward to prevent the coupler from drooping after prolonged use.

Abstract: Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure.

Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients.

Abstract: Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.

Abstract: According to an embodiment, power demands of a computing device or component thereof may be stabilized by performing redundant operations during periods of otherwise low power demand. In so doing, the current load of the device/component remains relatively stable, potentially greatly reducing voltage droops and overshoots. This can reduce the peak voltage and peak power rating of the device/component. In certain embodiments, such as in network switches and routers, the redundant operations may include queries against a content addressable memory (CAM), such as a ternary content addressable memory (TCAM). Moreover, in an embodiment the queries may be designed to always, or at least be highly likely to, miss the entries in the CAM, thereby ensuring maximum power usage. In another embodiment, the redundant operations include read operations on a random access memory (RAM). In other embodiments, redundant operations may be performed with respect to other power-intensive subsystems.

Abstract: A cushioning apparatus for a railway car employs a shortened yoke with a reduced-width tail for placement between stops in a conventional railway car sill. A first stack of rigid plates with elastomeric pads is provided between the straps of the modified yoke behind the coupler follower, and a second stack of plates and elastomeric pads is positioned in the sill behind the modified yoke to absorb buff loads on the coupler. In embodiments, the entire assembly may be placed in a sill having forward stops, intermediate stops, and rear stops, adapted to house a hydraulic cushioning unit.

Abstract: High affinity SIRP-? reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRP? reagent, which blocks the physiological binding interaction between SIRP? and its ligand CD47.

Abstract: High affinity SIRP-? reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRP? reagent, which blocks the physiological binding interaction between SIRP? and its ligand CD47.

Abstract: A cushioning apparatus for a railway car employs a shortened yoke with a reduced-width tail for placement between stops in a conventional railway car sill. A first stack of rigid plates with elastomeric pads is provided between the straps of the modified yoke behind the coupler follower, and a second stack of plates and elastomeric pads is positioned in the sill behind the modified yoke to absorb buff loads on the coupler. In embodiments, the entire assembly may be placed in a sill having forward stops, intermediate stops, and rear stops, adapted to house a hydraulic cushioning unit.

Abstract: A hybrid cushioning apparatus for a railway car apparatus employs a standard yoke and a conventional draft gear forward of the tail of the yoke and a stack of elastomeric units behind the tail engaging the draft gear with a force transfer member.

Abstract: A cushioning apparatus for a railway car employs a shortened yoke having a draft gear housing integral with the yoke. A stack elastomeric pads is provided in the housing, and a second stack of elastomeric pads and corresponding rigid metal plates, is positioned in the sill behind the modified yoke to absorb buff loads on the coupler. In embodiments, the entire assembly may be placed in a sill having forward stops, intermediate stops, and rear stops.

Abstract: A guide wire control device and methods of use are described herein. A novel method for optimizing a guide wire for a patient is described. The method includes steps of scanning a patient's anatomy and then fabricating, or selecting, a guide wire with optimal geometry for a particular patient and/or procedure. The guide wire may optionally be secured to a guide wire control device for improved control during transcatheter surgical procedures.