Patents by Inventor Michael S McGrath

Michael S McGrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5956047
    Abstract: The invention provides for a system and method for minimizing space requirements and increasing speed in a geometry accelerator for a computer graphics system. In architecture, the system is implemented as follows. The geometry accelerator includes a plurality of processing elements (e.g., an arithmetic logic unit, a multiplier, a divider, a compare mechanism, a clamp mechanism, etc.) and a plurality of control units (e.g., a transform mechanism, a decomposition mechanism, a clip mechanism, a bow-tie mechanism, a light mechanism, a classify mechanism, a plane equation mechanism, a fog mechanism, etc.) that utilize the processing elements for performing data manipulations upon image data. In accordance with the invention, the control units are implemented in a read-only memory (ROM) via microcode. A next address field is associated with each of the microcode instructions and defines a location in the ROM of a next instruction to be executed.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: September 21, 1999
    Assignee: Hewlett-Packard Co.
    Inventors: Alan S. Krech, Jr., Theodore G. Rossin, Edmundo Rojas, Michael S McGrath, Ted Rakel, Glenn W Strunk, Jon L Ashburn, S Paul Tucker
  • Patent number: 5877222
    Abstract: The invention comprises inhibiting expression of TNF-.alpha. by administering an effective amount of a stabilized activated oxygen in a matrix of chlorite ions. Preferably, a pharmaceutically acceptable formulation of tetrachlorodecaoxide is used, and more preferably, WF-10. An effective amount of WF-10 comprises up to about 0.5 ml/kg. Another embodiment of the invention is a method of treating AIDS-associated dementia comprising the step of administering to a human an amount of a stabilized activated oxygen in a matrix of chlorite ions sufficient to inhibit production of TNF-.alpha..
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: March 2, 1999
    Assignee: The Regents of the University of California
    Inventor: Michael S. McGrath
  • Patent number: 5744122
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: April 28, 1998
    Assignee: University of California, San Franciso
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Patent number: 5639600
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue and other cell proliferative diseased tissue. The invention also provides methods for the treatment of cell proliferative diseases induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: The Regents of the University of California
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Patent number: 5580715
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: December 3, 1996
    Assignee: The Regents of the University of California
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Patent number: 5508909
    Abstract: A method and system for generating a control program executable by an industrial controller, wherein a source program is displayed using a variable width ladder diagram. Instructions of a source program are received by a host computer, wherein the source program is compilable into the control program. A ladder diagram representative of at least one of the instructions of the source program is displayed on a display device. The ladder diagram comprises a graphical interconnection of schematic elements, at least one of which having a corresponding display width which is variable. The corresponding display width is varied in dependence upon the greater of a corresponding symbol display width and a corresponding label display width. A method and system for data communication with the industrial controller uses a hybrid error detection code.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: April 16, 1996
    Assignee: Patriot Sensors and Controls
    Inventors: Kenneth G. Maxwell, Michael S. McGrath, Jeffrey A. Millinton
  • Patent number: 5504902
    Abstract: A method and system for generating a control program executable by an industrial controller, wherein the control program is formed using instructions from a high-level text-based language and instructions from a ladder-based language. A source program is received by a host computer. At least one instruction of the source program in the high-level text-based language is displayed on a display device along with a corresponding ladder diagram of the source program in the ladder-based language. The source program is edited in either the high-level text-based language using a first editor or the ladder-based language using a second editor. Modifications of the source program made using the first editor and the second editor are converted to a lower-level language representation.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: April 2, 1996
    Assignee: Patriot Sensors and Controls Corporation
    Inventors: Michael S. McGrath, Lonny C. McKinnon, Jack C. Pattee, Gerald C. Wieczerza
  • Patent number: 5169753
    Abstract: A novel retrovirus isolated from human lymphoma cells is disclosed. The retrovirus is characterized by a C-type retroviral particle of approximately 100 nm diameter; and an approximately 27,000 molecular weight p24 core protein. Also disclosed are cell lines from which the virus can be obtained and screening methods for detecting the presence of the virus in human sera.
    Type: Grant
    Filed: January 2, 1992
    Date of Patent: December 8, 1992
    Assignees: Genelabs Incorporated, The University of California
    Inventors: Valerie L. Ng, Michael S. McGrath, Gregory R. Reyes
  • Patent number: 5108920
    Abstract: A novel retrovirus isolated from human lymphoma cells is disclosed. The retrovirus is characterized by a C-type retroviral particle of approximately 100 nm diameter; and an approximately 27,000 molecular weight p24 core protein. Also disclosed are cell lines from which the virus can be obtained and screening methods for detecting the presence of the virus in human sera.
    Type: Grant
    Filed: June 5, 1989
    Date of Patent: April 28, 1992
    Assignees: Regents of the University of California, Genelabs Incorporated
    Inventors: Valerie L. Ng, Michael S. McGrath, Gregory R. Reyes
  • Patent number: 4886743
    Abstract: This invention provides a reagent capable of binding to T cells and having specificity for a unique sequence within the variable region of the .beta. chain of the T cell receptor, the presence of increased number of T cells carrying the unique sequence relative to the number of T cells carrying the sequence present in a normal subject being associated with a specific disease. Specific diseases such as human cancers, e.g. lymphomas; autoimmune diseases, e.g. rheumatoid arthritis; Alzheimer's disease; infectious diseases, e.g. those caused by bacteria, yeast or parasite; or allergies, may be diagnosed as follows. A suitable sample containing T cells is obtained from a subject. The sample is contacted under appropriate conditions with such a reagent. If the subject's cells contain the unique sequence, a detectable complex is formed between the reagent and T cells which contain the sequence.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: December 12, 1989
    Assignee: California Institute of Technology
    Inventors: Leroy E. Hood, Irving L. Weissman, Michael S. McGrath
  • Patent number: 4869903
    Abstract: A method of inhibiting HIV replication in and cellular proliferation of HIV-infected cells. The infected cells are exposed to a single-chain ribosome inactivating protein, at a protein concentration and for an exposure period sufficient to produce a substantial reduction in (a) the level of HIV antigen or reverse transcriptase associated with the infected cells, (b) the ratio of viability of infected/uninfected T cells, and/or (c) the ratio of HIV antigen/cellular antigen in infected macrophages. The method is used to treat HIV infection in humans.
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: September 26, 1989
    Assignee: Genelabs Incorporated
    Inventors: Jeffrey D. Lifson, Michael S. McGrath, Hin-Wing Yeung, Kuo Hwang
  • Patent number: 4795739
    Abstract: A method of inhibiting expression of HIV antigens in human blood cells infected with HIV. The infected cells are exposed to a plant protein or glycoprotein, such as trichosanthin or momorcharin, at a concentration sufficient to (a) produce a substantial reduction in the level of HIV antigen, and (b) effect a selective reduction in the number of HIV-infected cells, with respect to uninfected cells of the same type. The method is used to treat HIV infection in humans. In another aspect, the invention includes a method of screening drug agents effective in treating HIV infection in humans.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: January 3, 1989
    Assignees: Gene Labs, Inc., Regents of University of California
    Inventors: Jeffrey D. Lifson, Michael S. McGrath, Hin-Wing Yeung, Kou M. Hwang
  • Patent number: 4786590
    Abstract: Specific binding members are provided for binding to lymphocytic cell surface receptors, which receptors are involved in the activation of a cell from the G.sub.0 state into the cell division cycle to proliferate. The cell surface receptors are further characterized by binding to envelope proteins of neoplasia-causing retroviruses, and/or to intact retroviral particles.
    Type: Grant
    Filed: January 15, 1985
    Date of Patent: November 22, 1988
    Assignees: California Institute of Technology, The Board of Trustees of the Leland Stanford, Jr. University
    Inventors: Michael S. McGrath, Irving L. Weissman