Abstract: The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Abstract: Methods and apparatuses for generating and displaying a model of a subject's teeth. Described herein are intraoral scanning methods and apparatuses for generating a three-dimensional model of a subject's intraoral region (e.g., teeth). These methods and apparatuses may be used for identifying and evaluating lesions, caries and cracks in the teeth.

Abstract: A system includes an intraoral scanner that generates a plurality of intraoral images of a dental site and a computing device. The computing device receives the plurality of intraoral images of the dental site during the intraoral scan session, registers the plurality of intraoral images together based on overlapping data of the plurality of intraoral images to generate a virtual three-dimensional (3D) model of the dental site, and fills in one or more missing areas in the virtual 3D model using data from a historical template.

Abstract: A scanning system comprises an intraoral scanner to capture scan data of a dental site and a computing device to generate a 3D rendering of the dental site. The scanner comprises one or more input devices configured to provide manual interaction with the computing device, where: a first activation of the input device(s) causes the scanning system to enter the scan mode, wherein the 3D rendering has a first visualization during the scan mode; and a second activation of the input device(s) causes the scanning system to enter an overlay mode, wherein the 3D rendering has a second visualization during the overlay mode, wherein the computing device is to present a menu comprising menu options on the display while the scanning system is in the overlay mode, and wherein the scanner is usable to select among the presented menu options.

Abstract: The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Abstract: Intraoral scanning systems for displaying 3D models of a patient's dental arch and near-IR images from the dental arch. These systems may include a wand with one or more image sensors and processors for processing the 3D models and near-IR information. The 3D models may include surface (e.g., color) information and the near-IR images may include information on internal structures, including enamel and dentin.

Abstract: A system includes an intraoral scanner that generates a plurality of intraoral images of a dental site and a computing device. The computing device generates a first surface of a first region of the dental site based on a first intraoral image and generates a second surface of a second region of the dental site based on a second intraoral image. The computing device determines relative positions of the first surface and the second surface, wherein overlap between the first region of the dental site represented in the first intraoral image and the second region of the dental site represented the second intraoral image is insufficient for registration of the second intraoral image to the first intraoral image. The computing device outputs the first surface and the second surface having the relative positions to a display.

Abstract: System for scanning a subject's teeth. Described herein are intraoral scanning apparatuses for generating a three-dimensional model of a subject's intraoral region (e.g., teeth). These apparatuses may be used for identifying and evaluating lesions, caries and cracks in the teeth.

Abstract: Apparatuses, including sleeves, intraoral scanning systems to use these sleeves, and methods of using the sleeve, that authenticate the sleeve for use with an intraoral scanning system. Authentication may include verifying that the sleeve is new (unused) and/or verifying that the sleeve is appropriate and/or intended for use with the intraoral scanning system. Once authenticated, operation parameters of the intraoral scanning system can be automatically set based on information from a scanned identifier on the sleeve.

Abstract: A system for intraoral scanning comprises a scanner to generate image data of a dental site and a computer readable medium. The computer readable medium includes instructs that, when executed by a processing device, cause the processing device receive a selection of library data for a reference object from library data for a plurality of reference objects in a library, receive the image data generated by the intraoral scanner, the image data comprising a representation of a dental site comprising the reference object, and align the library data for the reference object with the image data.

Abstract: Methods and apparatuses for taking, using and displaying three-dimensional (3D) volumetric models of a patient's dental arch. A 3D volumetric model may include surface (e.g., color) information as well as information on internal structure, such as near-infrared (near-IR) transparency values for internal structures including enamel and dentin.

Abstract: A processor receives first intraoral scan data comprising a first depiction of a dental site; generates a virtual three-dimensional (3D) model of the dental site using the first intraoral scan data; and processes at least one of the first intraoral scan data or data from the virtual 3D model to identify an unclear feature. The processor outputs instructions to generate second intraoral scan data of the dental site depicting the portion of the dental site that is unclear; receives the second intraoral scan data; and updates the virtual 3D model of the dental site using the second intraoral scan data, wherein the portion of the dental site that was unclear in the virtual 3D model is replaced with information from the second intraoral scan data.

Abstract: Methods and apparatuses for taking, using and displaying three-dimensional (3D) volumetric models of a patient's dental arch. A 3D volumetric model may include surface (e.g., color) information as well as information on internal structure, such as near-infrared (near-IR) transparency values for internal structures including enamel and dentin.

Abstract: In a method of generating a virtual 3D model of a dental site, scan data comprising a plurality of images of a dental site is received during an intraoral scan. An analysis of an image is performed. A representation of a reference object with known properties is identified in the image based on the analysis. A virtual 3D model of the dental site is generated based on the plurality of images. The image and/or the virtual 3D model of the dental site is modified by adding additional data about the reference object to the intraoral image and/or the virtual 3D model based on the one or more known properties of the reference object. If the image is modified, it may be modified prior to generation of the virtual 3D model, and the virtual 3D model may be generated using the modified image.

Abstract: A system for intraoral scanning comprises a scanner to generate image data of a dental site and a computing device. The computing device receives the image data of the dental site, the image data comprising a representation of the dental site and a representation of a reference object at the dental site. The computing device selects library data for the reference object from library data for a plurality of reference objects in a library. The computing device aligns the library data for the reference object with the image data.

Abstract: Apparatuses, including sleeves, intraoral scanning systems to use these sleeves, and methods of using the sleeve, that authenticate the sleeve for use with an intraoral scanning system. Authentication may include verifying that the sleeve is new (unused) and/or verifying that the sleeve is appropriate and/or intended for use with the intraoral scanning system. Once authenticated, operation parameters of the intraoral scanning system can be automatically set based on information from a scanned identifier on the sleeve.

Abstract: Methods and apparatuses for generating and displaying a model of a subject's teeth. Described herein are intraoral scanning methods and apparatuses for generating a three-dimensional model of a subject's intraoral region (e.g., teeth). These methods and apparatuses may be used for identifying and evaluating lesions, caries and cracks in the teeth.

Abstract: Methods and apparatuses for taking, using and displaying three-dimensional (3D) volumetric models of a patient's dental arch. A 3D volumetric model may include surface (e.g., color) information as well as information on internal structure, such as near-infrared (near-IR) transparency values for internal structures including enamel and dentin.

Abstract: A method includes receiving first intraoral scan data comprising a first depiction of a dental site comprising a preparation tooth; generating a virtual three-dimensional (3D) model of the dental site using the first intraoral scan data; processing at least one of the first intraoral scan data or data from the virtual 3D model to identify a margin line of the preparation tooth, wherein at least a portion of the margin line is unclear; outputting instructions to generate second intraoral scan data of the dental site depicting the portion of the margin line that is unclear; receiving the second intraoral scan data; and updating the virtual 3D model of the dental site using the second intraoral scan data, wherein the portion of the margin line that was unclear in the virtual 3D model is replaced with information from the second intraoral scan data.

Abstract: A processing device receives an intraoral image of a first intraoral site and determines an identity of the first intraoral site. The processing device then locks the intraoral image and selects a portion of the intraoral image depicting a portion of the first intraoral site based at least in part on the identity of the first intraoral site. The processing device may then generate a model comprising the first intraoral site based at least in part on the locked intraoral image, wherein the portion of the locked intraoral image is used for a first region of the model, and wherein data from one or more additional intraoral images that also depict the portion of the first intraoral site is not used for the first region of the model.