Abstract: Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation.

Abstract: The disclosure relates to a handrail disinfecting device for a handrail of a passenger transport installation. The handrail disinfecting device has a plurality of light-emitting diodes that can emit germicidal electromagnetic radiation in the region of their light cone. A pass-through segment of the handrail disinfecting device is divided into at least two sectors and has a carrier having planes that are arranged in the sectors. The light-emitting diodes are arranged on the carrier such that they are oriented according to the planes. In one of the sectors, there are two planes that are arranged in parallel with the longitudinal extension of the pass-through segment and so as to be mutually inclined at an angle of 100° to 160°.

Abstract: A computer-implemented method for executing a serverless workload on a transient infrastructure is disclosed. The method comprises receiving a request for executing a workload and at least one policy, selecting an infrastructure component of the transient infrastructure for an execution of the workload, wherein the transient infrastructure is implemented utilizing a plurality of geographically distributed computing nodes, and executing the workload on the transient infrastructure. Furthermore, the method comprises upon receiving an interfering event during the execution of the workload causing a stop of the workload execution, freezing the execution of the workload, storing intermediate results and statuses of the workload execution in a cross-domain storage system, terminating the execution of the workload, and continuing the workload execution using the intermediate results and under a constraint defined by the at least one policy.

Abstract: A framework section having a connection region which is formed on the end face of at least one of its two ends. The connection region can be connected to the connection region of a further framework section. The framework section can include two upper chord sections and two lower chord sections, which extend parallel to one another in the longitudinal direction of the framework section and are connected to one another by connecting struts such that they define a cuboid space. The upper chord sections and the lower chord sections can have a tubular cross section, wherein the upper chord sections and the lower chord sections can also be configured to transition from the tubular cross section into an I-shaped cross section in the connection region.

Abstract: A device (25) for drilling holes in bone and configured to determine bone screw length, the device (25) including a surgical power drill (2) comprising: a) a housing (12) and; b) a measuring device (1) releasably attached or fixed to the housing (12), wherein the measuring device (1) is configured to measure the distance (x) covered by the housing (12) in the direction of the longitudinal axis (7) and relative to a surface of an implant (26) or a bone during a drilling process, wherein the measuring device (1) comprises a processing unit (14) to record the distance (x) covered with respect to time; the processing unit (14) comprises one or more differentiators to determine at least the first and second derivatives of the distance (x) covered with respect to time; and the processing unit (14) further comprises a peak detector to analyze one or more peaks occurring in the graph of the highest derivative with respect to time, and wherein the measuring device (1) comprises a laser device or an ultrasound position

Abstract: A device (25) for drilling holes in bone and configured to determine bone screw length, the device (25) including a surgical power drill (2) comprising: a) a housing (12) and; b) a measuring device (1) releasably attached or fixed to the housing (12), wherein the measuring device (1) is configured to measure the distance (x) covered by the housing (12) in the direction of the longitudinal axis (7) and relative to a surface of an implant (26) or a bone during a drilling process, wherein the measuring device (1) comprises a processing unit (14) to record the distance (x) covered with respect to time; the processing unit (14) comprises one or more differentiators to determine at least the first and second derivatives of the distance (x) covered with respect to time; and the processing unit (14) further comprises a peak detector to analyze one or more peaks occurring in the graph of the highest derivative with respect to time, and wherein the measuring device (1) comprises a laser device or an ultrasound position

Abstract: An assembly for correcting unbalanced growth plate activity including: (a) an implant formed of wire having (i) a longitudinal central section (2), (ii) a first end (3) configured as a first loop (4) in a form of a first helical coil (9) having a central axis (5) that is transverse to a longitudinal axis of the central section, and (iii) a second end (6) configured as a second loop (7) having a central axis (8) that is transverse to the longitudinal axis of the central section; (b) a first bone screw having a shaft section that is insertable through the first loop; and (c) a second bone screw having a shaft section that is insertable through the second loop. A kit for correcting unbalanced growth plate activity and to a method for correcting unbalanced growth plate activity are also disclosed.

Abstract: A system for producing a winding bar for a stator winding of a stator of a rotating electric machine, in particular a turbine generator, having two machining units which can be arranged at a variable distance to each other. Each machining unit has machining device for machining an end portion of the winding bar, and each machining device is arranged on the respective machining unit in a pivotal manner about a pivot axis via at least one respective pivot arm. The pivot axis is identical to a longitudinal central axis of the rotating electric machine, and the radial distance between each machining device can be varied relative to the pivot axis.

Abstract: A device (25) for drilling holes in bone and configured to determine bone screw length, the device (25) including a surgical power drill (2) comprising: a) a housing (12) and; b) a measuring device (1) releasably attached or fixed to the housing (12), wherein the measuring device (1) is configured to measure the distance (x) covered by the housing (12) in the direction of the longitudinal axis (7) and relative to a surface of an implant (26) or a bone during a drilling process, wherein the measuring device (1) comprises a processing unit (14) to record the distance (x) covered with respect to time; the processing unit (14) comprises one or more differentiators to determine at least the first and second derivatives of the distance (x) covered with respect to time; and the processing unit (14) further comprises a peak detector to analyze one or more peaks occurring in the graph of the highest derivative with respect to time, and wherein the measuring device (1) comprises a laser device or an ultrasound position

Abstract: A device (25) for drilling holes in bone and configured to determine bone screw length, the device (25) including a surgical power drill (2) comprising: a) a housing (12) and; b) a measuring device (1) releasably attached or fixed to the housing (12), wherein the measuring device (1) is configured to measure the distance (x) covered by the housing (12) in the direction of the longitudinal axis (7) and relative to a surface of an implant (26) or a bone during a drilling process, wherein the measuring device (1) comprises a processing unit (14) to record the distance (x) covered with respect to time; the processing unit (14) comprises one or more differentiators to determine at least the first and second derivatives of the distance (x) covered with respect to time; and the processing unit (14) further comprises a peak detector to analyze one or more peaks occurring in the graph of the highest derivative with respect to time, and wherein the measuring device (1) comprises a laser device or an ultrasound position

Abstract: The bone plate (1) has a lower surface (2), an upper surface (3), a thickness T measured between the lower and upper surfaces (2;3), a longitudinal axis (4) and a plurality of plate holes (5) running from the lower surface (2) to the upper surface (3). The bone plate (1) further has a slot (6) extending from the lower surface (2) towards the upper surface (3) and having a width W measured at the lower surface (2) and parallel to the longitudinal axis (4). The slot (6) extends to a maximum distance D measured from the lower surface (2) towards the upper surface (3) of 0.4-0.9 times the thickness T of the bone plate (1). The slot (6) has a width measured parallel to the longitudinal axis (4) which at its maximum extension E is at least 0.8 mm, preferably of at least 3 mm. The slot (6) allows the plate (1) to bend longitudinally—additionally to the intrinsic bendability of the unslotted plate (1)—at most to the amount of 20°, preferably at most to the amount of 10°.

Abstract: An assembly for correcting unbalanced growth plate activity including: (a) an implant formed of wire having (i) a longitudinal central section (2), (ii) a first end (3) configured as a first loop (4) in a form of a first helical coil (9) having a central axis (5) that is transverse to a longitudinal axis of the central section, and (iii) a second end (6) configured as a second loop (7) having a central axis (8) that is transverse to the longitudinal axis of the central section; (b) a first bone screw having a shaft section that is insertable through the first loop; and (c) a second bone screw having a shaft section that is insertable through the second loop. A kit for correcting unbalanced growth plate activity and to a method for correcting unbalanced growth plate activity are also disclosed.

Abstract: A steam cycle for a power station, and to a method for operating, in particular for starting, a steam cycle. The steam cycle has a high-pressure turbine, a condenser and a steam generator. The steam generator is connected to the high-pressure turbine via a first line. Live steam quick-closing valves and live steam regulating valves for supplying the high-pressure turbine are arranged in the direction of the steam flow between the steam generator and the high-pressure turbine. A starting line is arranged downstream of the high-pressure turbine in the direction of the steam flow, the starting line connecting a waste steam region downstream of the high-pressure turbine with the condenser. At least one regulator regulates a closing of a starting valve for sealing the starting line, and an opening of the live steam valve, depending on the rotational speed, a temperature and load state of the high-pressure turbine.

Abstract: A device (25) for drilling holes in bone and configured to determine bone screw length, the device (25) including a surgical power drill (2) comprising: a) a housing (12) and; b) a measuring device (1) releasably attached or fixed to the housing (12), wherein the measuring device (1) is configured to measure the distance (x) covered by the housing (12) in the direction of the longitudinal axis (7) and relative to a surface of an implant (26) or a bone during a drilling process, wherein the measuring device (1) comprises a processing unit (14) to record the distance (x) covered with respect to time; the processing unit (14) comprises one or more differentiators to determine at least the first and second derivatives of the distance (x) covered with respect to time; and the processing unit (14) further comprises a peak detector to analyze one or more peaks occurring in the graph of the highest derivative with respect to time, and wherein the measuring device (1) comprises a laser device or an ultrasound position

Abstract: A system for producing a winding bar for a stator winding of a stator of a rotating electric machine, in particular a turbine generator, having two machining units which can be arranged at a variable distance to each other. Each machining unit has machining device for machining an end portion of the winding bar, and each machining device is arranged on the respective machining unit in a pivotal manner about a pivot axis via at least one respective pivot arm. The pivot axis is identical to a longitudinal central axis of the rotating electric machine, and the radial distance between each machining device can be varied relative to the pivot axis.

Abstract: A cleaning device is provided, including an electrical consumption unit, at least two batteries, a discharge circuit electrically connecting these to the consumption unit, and a control unit for controlling the discharge circuit, wherein the batteries are connected to each other in parallel. To increase the utility and operational safety of the cleaning device, in the discharge operation of the cleaning device, a parameter reflecting a respective state of charge of the batteries is determinable, and the discharge circuit is controllable by the control unit such that, depending on the result of the determination, a respective discharge current path for the respective battery, in which discharge current path the consumption unit is arranged, is optionally releasable or blockable by means of at least one electrical switching element. In addition, methods for operating a cleaning device are provided.

Abstract: The bone plate (1) has a lower surface (2), an upper surface (3), a thickness T measured between the lower and upper surfaces (2;3), a longitudinal axis (4) and a plurality of plate holes (5) running from the lower surface (2) to the upper surface (3). The bone plate (1) further has a slot (6) extending from the lower surface (2) towards the upper surface (3) and having a width W measured at the lower surface (2) and parallel to the longitudinal axis (4). The slot (6) extends to a maximum distance D measured from the lower surface (2) towards the upper surface (3) of 0.4-0.9 times the thickness T of the bone plate (1). The slot (6) has a width measured parallel to the longitudinal axis (4) which at its maximum extension E is at least 0.8 mm, preferably of at least 3 mm. The slot (6) allows the plate (1) to bend longitudinally—additionally to the intrinsic bendability of the unslotted plate (1)—at most to the amount of 20°, preferably at most to the amount of 10°.

Abstract: A cleaning tool for a floor cleaning appliance is provided, including a main body carrying a cleaning cover which is subject to wear, and including a signal transmitter which provides a wireless signal in dependence upon the degree of wear of the cleaning cover. To be able to detect in a cost-effective manner when a maximum admissible degree of wear of the cleaning cover is reached, the signal transmitter is of rigid construction and fixed to a movable carrying part, the carrying part being held on the main body and being movable from a normal position to an evasive position against a restoring force, the carrying part protruding further from the main body in the normal position than in the evasive position, and the carrying part and/or the signal transmitter contacting the floor surface to be cleaned when a maximum admissible degree of wear of the cleaning cover is reached.

Abstract: A steam cycle for a power station, and to a method for operating, in particular for starting, a steam cycle. The steam cycle has a high-pressure turbine, a condenser and a steam generator. The steam generator is connected to the high-pressure turbine via a first line. Live steam quick-closing valves and live steam regulating valves for supplying the high-pressure turbine are arranged in the direction of the steam flow between the steam generator and the high-pressure turbine. A starting line is arranged downstream of the high-pressure turbine in the direction of the steam flow, the starting line connecting a waste steam region downstream of the high-pressure turbine with the condenser. At least one regulator regulates a closing of a starting valve for sealing the starting line, and an opening of the live steam valve, depending on the rotational speed, a temperature and load state of the high-pressure turbine.

Abstract: The invention relates to a drainage trench unit (10) which comprises at least one drainage trench sub-unit (12), the at least one drainage trench sub-unit (12) having a base wall (16) and a plurality of hollow pillars (18), said pillars (18) being connected integrally to the base wall (16) and tapering, preferably conically, away from the base wall (16), i.e. tapering from their base end (18a) to their top end (18b). The invention also relates to a transport unit for transporting a plurality of such drainage trench units (10).