Abstract: Tacrolimus is an immunosuppressant drug. The present disclosure provides an anti-fibrotic agent by transforming Tacrolimus, such that the anti-fibrotic agent is used for treating fibrosis. The anti-fibrotic agent is not immunosuppressant. In one embodiment, the present invention provides a method to transform Tacrolimus into an anti-fibrotic agent.

Abstract: Tacrolimus is an immunosuppressant drug. The present disclosure provides an anti-fibrotic agent by transforming Tacrolimus, such that the anti-fibrotic agent is used for treating fibrosis. The anti-fibrotic agent is not immunosuppressant. In one embodiment, the present invention provides a method to transform Tacrolimus into an anti-fibrotic agent.

Abstract: The present compositions and methods generally relate to the treatment of diseases, such as idiopathic pulmonary fibrosis (IPF) and neurodegenerative diseases related to tau aggregation.

Abstract: The present application discloses compositions and methods useful for treating and preventing inflammation associated with inflammatory diseases and disorders.

Abstract: A system, computer-readable storage medium storing at least one program, and a computer-implemented method for providing synchronous multiplayer games are presented. To begin, an enabling request for multiplayer functionality in a multiplayer instance that includes a single player mode game is received. The single player mode game may involve a game board dedicated to a first player. Then, the single player mode game of the multiplayer instance is matched with additional multiplayer instances. Each additional multiplayer instance includes a corresponding single player mode game dedicated to a respective player. The single player mode games from the multiplayer instance and the additional multiplayer instances are then instructed to initiate gameplay at substantially the same time. Final scores from the single player mode games from the multiplayer instance and the additional multiplayer instances are collected. A game summary page is finally communicated to the first player and the respective players.

Abstract: A system, machine-readable storage medium storing at least one program, and a computer-implemented method for icon optimization in a game user interface is provided. A request from a client device to access a game user interface of a player may be received, where the game user interface is associated with one or more computer-implemented games hosted by a game networking system. A first manner of displaying one or more icons each representing a computer-implemented game of the one or more computer-implemented games is determined. The first manner of displaying the one or more icons within the game user interface is determined based on one or more game-related factors specific to the player. Display data to display the one or more icons in the first manner may be generated and provided to the client device.

Abstract: The present application discloses compositions and methods useful for treating and preventing inflammation associated with inflammatory diseases and disorders.