Patents by Inventor Michael Szycher
Michael Szycher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8367094Abstract: This invention provides a modified catheter/indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA) as an option, a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation. Alternatively, the sparsely soluble silver salt can be silver iodate and is combined with silver sulfadiazine. Chlorhexidine can also be included in the material.Type: GrantFiled: February 22, 2012Date of Patent: February 5, 2013Inventor: Michael Szycher
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Publication number: 20120150095Abstract: This invention provides a modified catheter/indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA) as an option, a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation. Alternatively, the sparsely soluble silver salt can be silver iodate and is combined with silver sulfadiazine. Chlorhexidine can also be included in the material.Type: ApplicationFiled: February 22, 2012Publication date: June 14, 2012Inventor: Michael Szycher
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Patent number: 8173151Abstract: This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation.Type: GrantFiled: July 7, 2011Date of Patent: May 8, 2012Inventor: Michael Szycher
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Publication number: 20110288498Abstract: This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation.Type: ApplicationFiled: July 7, 2011Publication date: November 24, 2011Inventor: Michael Szycher
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Patent number: 7998498Abstract: This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation.Type: GrantFiled: December 31, 2008Date of Patent: August 16, 2011Inventor: Michael Szycher
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Publication number: 20090186064Abstract: This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation.Type: ApplicationFiled: December 31, 2008Publication date: July 23, 2009Inventor: Michael Szycher
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Publication number: 20050196375Abstract: The invention provides urethane polymers bonded to therapeutically active compounds, such as antibiotics. The invention also features methods of applying therapeutically active compounds to polyurethane polymers using textile dyeing. These polymers may be used in a variety of clinical applications.Type: ApplicationFiled: April 20, 2005Publication date: September 8, 2005Inventors: Matthew Phaneuf, William Quist, Michael Szycher, Martin Bide, Frank LoGerfo
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Publication number: 20040093068Abstract: A stent including a tubular metal frame having at least two ends and interior luminal and exterior non-luminal surfaces. The stent includes at least one fixation ring at each end of the frame non-rigidly connected to the frame by a plurality of fasteners. The fixation ring is a metal ring having a smooth zig-zag pattern and a plurality of spikes located on an exterior surface. The stent may be encapsulated by a smooth polymeric coating, and a textured polymeric coating may be disposed over the exterior non-luminal surface of the encapsulating stent.Type: ApplicationFiled: January 23, 2003Publication date: May 13, 2004Inventors: Lee C. Bergen, Michael Szycher
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Publication number: 20020133224Abstract: A stent substantially completely encapsulated with a microporous polymeric membrane is provided. Encapsulation of the stent may be accomplished by an electrostatic deposition process. The microporous polymeric membrane may contain variable concentrations of one or more pharmacotherapeutic agents. After deployment to a site of interest, the stent and more specifically, the membrane, provides local delivery of sustained or controlled therapeutic dose of one or more of suitable pharmacotherapeutic agent.Type: ApplicationFiled: March 6, 2002Publication date: September 19, 2002Inventors: Clara Bajgar, Michael Szycher
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Publication number: 20010049422Abstract: The invention provides urethane polymers bonded to therapeutically active compounds, such as antibiotics. The invention also features methods of applying therapeutically active compounds to polyurethane polymers using textile dyeing. These polymers may be used in a variety of clinical applications.Type: ApplicationFiled: April 13, 2001Publication date: December 6, 2001Inventors: Matthew D. Phaneuf, William C. Quist, Michael Szycher, Martin J. Bide, Frank W. LoGerfo
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Patent number: 6117535Abstract: Filament-reinforced biomedical devices, and methods of making them.Type: GrantFiled: January 14, 1998Date of Patent: September 12, 2000Assignee: Cardiotech International, Inc.Inventors: Michael Szycher, Alan Edwards, Donald Dempsey, Jacob Leidner, David G. Cook
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Patent number: 5863627Abstract: A biocompatible, biodurable polycarbonate polyurethane with internal polysiloxane segments and devices made therefrom.Type: GrantFiled: August 26, 1997Date of Patent: January 26, 1999Assignee: CardioTech International, Inc.Inventors: Michael Szycher, Donald Dempsey, Alan Edwards
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Patent number: 5653699Abstract: A sheet-form composite suitable as a spyrosorbent wound dressing and exhibiting differential moisture vapor transport rate properties is disclosed. The sheet-form composite includes a hydrophilic, monolithic film layer characterized by having a differential ratio of wet to dry moisture transport rate greater than 1 and a dry moisture transport rate greater than about 2,600 g/m.sup.2 /24 hrs. This film layer is laminated to a hydrophilic exudate transport layer. The exudate transport layer can itself be, or can further include, a hydrophilic pressure sensitive adhesive applied in a continuous or discontinuous pattern. The sheet-form composite has a moisture vapor transport rate of greater than 2,000 g/m.sup.2 /24 hrs when dry, and a wet to dry moisture vapor transport rate ratio in the range of about 1.5 to about 10.Type: GrantFiled: September 13, 1994Date of Patent: August 5, 1997Assignee: Polymedica Industries, Inc.Inventors: Andrew M. Reed, Jon M. Potter, Michael Szycher
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Patent number: 5254662Abstract: Polyurethane products having long-term biostability in combination with a low modulus of elasticity and a high ultimate tensile strength and other desireable mechanical properties which are particularly useful as leads for implantable pacemakers, as vascular grafts, as mammary prostheses, and as other products which are intended to be placed within the body of a mammal for extended periods with no substantial degradation of the product. The polyurethanes are prepared from the reaction of an organic diisocyanate, preferably an aliphatic or cycloaliphatic diisocyanate with polycarbonate glycol chained extended with diol, diamine or a mixture of diamine and alkanolamine.Type: GrantFiled: May 18, 1992Date of Patent: October 19, 1993Assignee: PolyMedia Industries, Inc.Inventors: Michael Szycher, Andrew M. Reed
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Patent number: 5118779Abstract: A non-toxic hydrophilic polyurethane elastomer having less than about 0.5% by weight extractables and which is curable in the absence of heat is disclosed. The elastomers are prepared from suitable hydrophilic polyurethane oligomers in combination with suitable ultraviolet light absorbers which become chemically bound into the elastomer during the polymerization (curing) thereof and thus become essentially non-extractable therefrom.Type: GrantFiled: October 10, 1989Date of Patent: June 2, 1992Assignee: PolyMedica Industries, Inc.Inventor: Michael Szycher
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Patent number: 4880690Abstract: A perfume patch comprising a fragrance-emitting member having a fragrance dispersed within an ultra-thin polyurethane membrane. A layer of pressure sensitive adhesive is applied to adhere the member to a surface. The polyurethane is formed from a diisocyanate, a macroglycol, and an acrylyl chain terminator to which a photoinitiator and a fragrance oil are added prior to curing. A barrier layer may be applied by an adhesive or other suitable means to prevent migration of the fragrance oil to the adhesive so that no residue of adhesive remains on the surface. The perfume patch preferably includes a support for the fragrance-emitting member for ease in application and handling.Type: GrantFiled: September 9, 1988Date of Patent: November 14, 1989Assignee: Thermedics, Inc.Inventors: Michael Szycher, Jonathan L. Rolfe
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Patent number: 4751133Abstract: A layer or member particularly useful as part of a medical patch such as an anisotropic wound dressing, a transdermal skin patch or an incise medical drape and the processes for forming such a member. The member is comprised of a crosslinked thermoset aliphatic polyurethane elastomer. The elastomer is the reaction product of (1) isophorone diisocyanate, (2) a macroglycol and (3) a chain terminator having both hydroxyl and vinyl functional groups. Polycarbonate glycols or polyetherglycols having a molecular weight of 500-2500 Daltons are preferred macroglycols and isophorone diamine is a preferred chain terminator. In one embodiment, a member or polyurethane layer for use as a wound dressing or an incise medical drape is produced by applying a film-forming solution or dispersion as a thin film to a supporting release paper and treating the film to drive off the liquids and to activate a crosslinker.Type: GrantFiled: May 11, 1987Date of Patent: June 14, 1988Assignee: Thermedics, Inc.Inventors: Michael Szycher, Jonathan L. Rolfe
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Patent number: 4727868Abstract: An anisotropic wound dressing comprised of a knitted reinforcing fabric which is sandwiched between a crosslinked aliphatic polyurethane. The wound dressing is fabricated by dipping the fabric into a polyurethane-forming coating solution to form a thin film which coates the fibres of the fabric and fills the interstices with a film or layer. The film which coats the fabric is cured by ultraviolet radiation and one side of the film is coated with pressure sensitive adhesive to form a wound dressing. In the most preferred embodiments, the knitted reinforcing fabric is an anisotropic fabric formed with a basic stitch construction to create equally spaced and sized hexagonal interstices. Because of the fabric reinforcement, the resulting oxygen permeable product can be made thin, and yet be anisotropic and strong. The resulting product does not wrinkle easily and holds its shape so it is also easily applied.Type: GrantFiled: May 20, 1987Date of Patent: March 1, 1988Assignee: Thermedics, Inc.Inventors: Michael Szycher, Jonathan L. Rolfe
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Patent number: 4638043Abstract: A drug releasing system in the form of a medical patch comprised of a drug dispensing polyurethane member as a matrix for a therapeutically effective amount of drug dispersed therein. The polyurethane of the drug dispensing or releasing member is a polyurethane acrylic copolymer which is the reaction product of an oligomer of a diisocyanate, a glycol with a molecular weight between the range of 500-5,000 molecular weight units and an acrylyl chain terminator having a molecular weight between the range of 40-200 molecular weight units cured by actinic radiation. In its preferred embodiment, the foregoing drug releasing or dispensing member is incorporated into a medical patch or drug release system comprised of successive layers of an ultrathin polyurethane substrate, pressure sensitive adhesive, the above-described drug releasing member and optionally a second layer of adhesive.Type: GrantFiled: August 23, 1985Date of Patent: January 20, 1987Assignee: Thermedics, Inc.Inventors: Michael Szycher, Donald J. Dempsey, Jonathan L. Rolfe
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Patent number: RE32991Abstract: The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyante terminated prepolymer formed by reaction of isophorone diisocyanate and a marcoglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat.In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of:dicyclohexyl methane diisocyanate;a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and1,4-butane diol.That solution is then admixed with the pharmacoactive agent, formed into a film and cured.Type: GrantFiled: July 25, 1988Date of Patent: July 18, 1989Assignee: Thermedics, Inc.Inventors: Michael Szycher, Donald J. Dempsey, Jonathan L. Rolfe