Abstract: An air-pressure splint sized to fully encase an injured human leg. The splint comprises inner and outer flexible wall members which are joined to each other by seaming about the perimeter to define an air-tight sealed relationship between the walls forming a double-walled, sealed, inflatable envelope. The envelope has separable air-tight margins adapted to be releasably connected to each other by a zipper-type fastener to hold the pressure splint in a surrounding position around the human leg. The upper end of the envelope has an uneven peripheral contour such that a portion of the envelope end extends upward above the leg for restraining the splint against rotation about the injured leg when the splint is in an inflated mode.