Patents by Inventor Michael Tarlov

Michael Tarlov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070134684
    Abstract: The method provides for attaching nucleic acids to a surface at a controlled grafting density in a controlled conformation by contacting an immobilization solution of nucleic acids containing at least one block of adenine nucleotides to a surface for a sufficient period of time to allow attachment to the surface. Another aspect of the methods described provides for controlling the grafting density of immobilized oligonucleotides by coadsorption/displacement by oligo(dA). Another aspect provides for a method of immobilizing oligonucleotides in complex conformations by varying the number and position of the block(s) of adenine nucleotides in the sequence of said oligonucleotides. Another aspect provides for controlled immobilization of a functional unit, such as a ligand, a molecule, a macromolecule, an aptamer, a lectin, an immunoglobulin, an antibody, a biomolecule, a solid state particle, a vesicle, or a label to a surface via attachment to at least one block of adenine nucleotides.
    Type: Application
    Filed: July 14, 2006
    Publication date: June 14, 2007
    Inventors: Dmitri Petrovykh, Lloyd Whitman, Michael Tarlov, Aric Opdahl, Hiromi Kimura-Suda
  • Publication number: 20050145495
    Abstract: A method is provided for observing mixing interactions and reactions of two materials in a fluid. The method in one form provides for concentrating by balancing electrophoretic velocities of a material against the bulk flow of fluid in the presence of a temperature gradient. Using an appropriate fluid, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity of the material so that the electrophoretic and bulk velocities sum to zero at a unique position and the material will be focused at that position. A second material can then be introduced into the fluid and allowed to move through and interact with the focused band of the first material. Products of the interaction can then be detected as they are focused at a different position along the gradient. The method can be adapted to study the temperature dependence of the molecular interaction.
    Type: Application
    Filed: January 24, 2005
    Publication date: July 7, 2005
    Inventors: David Ross, Michael Tarlov, Karin Balss