Abstract: A method for delivering liquid into the pores of recipient human skin is provided. The method comprises delivering, via a nozzle, at least one stream of the liquid under pressure to the pores, the stream having a cross-section with a diameter no greater than about 50 ?m, applying a negative pressure across an area of the skin being treated, rotating the nozzle relative to the area at a speed up to about 200 revolutions per minute, contacting an electrode connected to a first terminal of a power source, having a first electric charge, to the skin, and contacting a second terminal of the power source, having a second electric charge, opposite the first electric charge, to the liquid, thereby imparting an electrical current between about 0.2 mA and 0.3 mA to the skin in the vicinity of the pores. The delivering, applying, rotating, and contactings occur simultaneously.

Abstract: A method for delivering liquid into the pores of a recipient human skin is provided. The method includes delivering via a nozzle, at least one stream of the liquid under pressure to the pores, the stream having a cross-section with a diameter no greater than about 50 ?m, applying a negative pressure across an area of the skin being treated, rotating the nozzle relative to the area at a speed up to about 200 revolutions per minute, contacting an electrode connected to a first terminal of a power source, having a first electric charge, to the skin, and contacting a second terminal of the power source, having a second electric charge, opposite the first electric charge, to the liquid, thereby imparting direct electrical current (DC) between about 5 ?A and 0.1 mA to the skin in the vicinity of the pores. The delivering, applying, rotating, and contacting occur simultaneously.

Abstract: A method for delivering liquid into the pores of recipient human skin is provided. The method comprises delivering, via a nozzle, at least one stream of the liquid under pressure to the pores, the stream having a cross-section with a diameter no greater than about 50 ?m, applying a negative pressure across an area of the skin being treated, rotating the nozzle relative to the area at a speed up to about 200 revolutions per minute, contacting an electrode connected to a first terminal of a power source, having a first electric charge, to the skin, and contacting a second terminal of the power source, having a second electric charge, opposite the first electric charge, to the liquid, thereby imparting an electrical current between about 0.2 mA and 0.3 mA to the skin in the vicinity of the pores. The delivering, applying, rotating, and contactings occur simultaneously.

Abstract: The present invention relates to a device for abrading or cleansing tissue. The device includes a gas inlet port connected to a pressurized gas source, and a liquid inlet port connected to a pressurized liquid source. There is, additionally, a mist jet delivery nozzle arrangement, which includes one or more gas discharge nozzles arranged to receive a flow of pressurized gas from the gas inlet port and configured to accelerate the flow of gas so as to discharge it at an elevated velocity. Further, there are one or more liquid discharge nozzles arranged to receive a flow of liquid from the liquid inlet port and operative to discharge the flow of liquid into the elevated velocity flow of gas, thereby to similarly accelerate the velocity of the discharged liquid as a mist of accelerated droplets.

Abstract: A liquid cutting device employing pressurized working liquid which includes a nozzle assembly. The assembly includes a plurality of liquid jet nozzles, each nozzle of which has a nozzle axis. The plurality of nozzles are arranged so that their nozzle axes intersect at an intersection point located at a predetermined distance downstream from the nozzles. The device also includes an apparatus for delivering the pressurized working liquid to the nozzles. Each of the nozzles is configured to selectably emit a liquid jet operative to cut through a target material. The liquid jets emitted from the nozzles interfere and disperse each other when meeting at the intersection point and the liquid jets are atomized. The device includes a spacer element adjustably mounted onto the nozzle assembly, which increases or decreases the cutting depth of the device. A method for employing the liquid cutting device is also discussed.

Abstract: A device for electroporation of tissue is provided. The device includes a mist jet delivery nozzle arrangement that is connected to a pressurized gas source and also connected to a liquid source. The device also includes a charge generator in electrical communication with the liquid provided by the liquid source wherein the generator supplies charge to the liquid. The delivery nozzle arrangement is arranged and operative to accelerate and emit the pressurized gas and to accelerate and emit the liquid as a mist of accelerated charged droplets. The charged droplets alight, and then electrically discharge, on the tissue being treated.

Abstract: A device and a method for improved treatment of tissue by direct application thereto of desired therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas produced by accelerating a flow of gas through at least one gas discharge nozzle so as to provide a gas discharge flow at an elevated velocity, and introducing into the elevated velocity gas discharge flow at least one flow of therapeutic liquid, through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets, and accelerating the stream to an accelerated velocity similar to the velocity of the gas discharge flow, and then applying the accelerated therapeutic droplet stream to a tissue mass desired for therapeutic treatment thereby.

Abstract: The present invention relates to a device for abrading or cleansing tissue. The device includes a gas inlet port connected to a pressurized gas source, and a liquid inlet port connected to a pressurized liquid source. There is, additionally, a mist jet delivery nozzle arrangement, which includes one or more gas discharge nozzles arranged to receive a flow of pressurized gas from the gas inlet port and configured to accelerate the flow of gas so as to discharge it at an elevated velocity. Further, there are one or more liquid discharge nozzles arranged to receive a flow of liquid from the liquid inlet port and operative to discharge the flow of liquid into the elevated velocity flow of gas, thereby to similarly accelerate the velocity of the discharged liquid as a mist of accelerated droplets.

Abstract: The present invention is a method of dermal abrasion, that includes exposing a source of sterile liquid to a flow of pressurized gas, thereby causing a pumped supply thereof into a fluid delivery head (200); supplying the pressurized gas to the fluid delivery head; combining the gas, and liquid (204) supplied to the delivery head; this fluid delivery head having a fluid outlet (206) with a predetermined internal diameter (210), so as to provide a gas-liquid outflow in the form of a sterile liquid mist jet suspended in a high velocity gas stream; and exposing to the mist jet, at a preselected distance from the fluid outlet, a portion of the skin surface (224) sought to be abraded, thereby separating therefrom at least a portion of the epidermis (225), and removing therefrom the resulting tissue debris.

Abstract: An apparatus employing liquid and gas as working fluids for cleansing living tissue includes a container for a sterile liquid and a fluid delivery head having a liquid entry port, a gas entry port, a fluid outlet apparatus and a valve located between the entry ports and the fluid outlet apparatus. The valve selectively permits respective liquid and gas flows from the entry ports to the fluid outlet apparatus. A liquid conduit extends between a liquid inlet located within the container and a liquid outlet connected to the liquid entry port of the delivery head. A gas conduit extends between a gas inlet and a gas outlet. The gas inlet is connected to a source of pressurized gas and the gas outlet is connected to the gas entry port of the delivery head. The gas conduit is connected to the container via an intermediate outlet port.