Patents by Inventor Michael Titus
Michael Titus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230159585Abstract: This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk chromatographic isolation of proteins (e.g., recombinant proteins) from the egg white, as well as method of filtering acidified egg white and methods of isolating proteins from the egg white.Type: ApplicationFiled: November 11, 2022Publication date: May 25, 2023Applicant: ALEXION PHARMACEUTICALS, INC.Inventors: Liang CHEN, Markley C. LEAVITT, Michael TITUS
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Patent number: 11634238Abstract: In an embodiment, a system includes a frame configured to support a load, a first set of wheels provided on the frame, a second set of wheels provided on the frame, and a controller. The first set of wheels is configured to descend or ascend in response to the controller, and is oriented to move in a first direction. The second set of wheels is configured to descent or ascend in response to the controller, and is oriented to move in a different direction from the first direction. The controller configured to control the descent and ascent of the second set of wheels and the first set of wheels.Type: GrantFiled: May 28, 2019Date of Patent: April 25, 2023Assignee: Kitty Hawk CorporationInventors: Michael Titus Waithaka Kiiru, Todd Reichert, Cameron Robertson
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Patent number: 11155794Abstract: The present invention is related a method of purifying a heterologous protein from an egg white. In some embodiments, the disclosure is directed to a method of purifying a heterologous protein from an egg white comprising the heterologous protein, the method comprising, (a) adjusting the pH of the egg white to a pH of 5.8 to 6.5 to form a pH-adjusted egg white; (b) filtering the pH-adjusted egg white of (a) and collecting a first filtrate; (c) subjecting the first filtrate of (b) to a hydrophobic interaction chromatography matrix, and collecting a first eluate comprising the heterologous protein; (d) adjusting the pH of the first eluate of (c) to a pH of 5.0 to 5.6 to form a pH-adjusted eluate; (e) filtering the pH-adjusted eluate to obtain a second filtrate; (f) adjusting the pH of the second filtrate to a pH of 3.0 to 4.0 to form a pH-adjusted second filtrate; (g) neutralizing the pH-adjusted second filtrate of (f) to a pH of 5.0 to 8.Type: GrantFiled: August 22, 2017Date of Patent: October 26, 2021Assignee: ALEXION PHARMACEUTICALS, INC.Inventors: Liang Chen, Markley C. Leavitt, Michael Titus, Stephen Palmieri
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Publication number: 20190177708Abstract: The present invention is related a method of purifying a heterologous protein from an egg white. In some embodiments, the disclosure is directed to a method of purifying a heterologous protein from an egg white comprising the heterologous protein, the method comprising, (a) adjusting the pH of the egg white to a pH of 5.8 to 6.5 to form a pH-adjusted egg white; (b) filtering the pH-adjusted egg white of (a) and collecting a first filtrate; (c) subjecting the first filtrate of (b) to a hydrophobic interaction chromatography matrix, and collecting a first eluate comprising the heterologous protein; (d) adjusting the pH of the first eluate of (c) to a pH of 5.0 to 5.6 to form a pH-adjusted eluate; (e) filtering the pH-adjusted eluate to obtain a second filtrate; (f) adjusting the pH of the second filtrate to a pH of 3.0 to 4.0 to form a pH-adjusted second filtrate; (g) neutralizing the pH-adjusted second filtrate of (f) to a pH of 5.0 to 8.Type: ApplicationFiled: August 22, 2017Publication date: June 13, 2019Inventors: Liang CHEN, Markley C. LEAVITT, Michael TITUS, Stephen PALMIERI
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Publication number: 20180244716Abstract: This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk chromatographic isolation of proteins (e.g., recombinant proteins) from the egg white, as well as method of filtering acidified egg white and methods of isolating proteins from the egg white.Type: ApplicationFiled: February 23, 2018Publication date: August 30, 2018Applicant: ALEXION PHARMACEUTICALS, INC.Inventors: Liang CHEN, Markley C. LEAVITT, Michael TITUS
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Patent number: 9938319Abstract: This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk chromatographic isolation of proteins (e.g., recombinant proteins) from the egg white, as well as methods of filtering acidified egg white and methods of isolating proteins from the egg white.Type: GrantFiled: April 21, 2015Date of Patent: April 10, 2018Assignee: ALEXION PHARMACEUTICALS, INC.Inventors: Liang Chen, Markley C. Leavitt, Michael Titus
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Publication number: 20150307547Abstract: This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk chromatographic isolation of proteins (e.g., recombinant proteins) from the egg white, as well as methods of filtering acidified egg white and methods of isolating proteins from the egg white.Type: ApplicationFiled: April 21, 2015Publication date: October 29, 2015Inventors: Liang Chen, Markley C. Leavitt, Michael Titus
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Patent number: 8513219Abstract: The invention relates to novel and known substituted phosphonates for use in ameliorating amyloid aggregates, particularly for use in the treatment of Alzheimer's disease.Type: GrantFiled: May 2, 2008Date of Patent: August 20, 2013Assignee: Queen Mary & Westfield College, University of LondonInventors: Alice Sullivan, Adina Michael-Titus, Lesley Robson
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Publication number: 20100204183Abstract: The invention relates to novel and known substituted phosphonates for use in ameliorating amyloid aggregates, particularly for use in the treatment of Alzheimer's disease.Type: ApplicationFiled: May 2, 2008Publication date: August 12, 2010Applicant: QUEEN MARY & WESTFIELD COLLEGEInventors: Alice Sullivan, Adina Michael-Titus, Lesley Robson
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Patent number: 6942794Abstract: The present invention is a flow distributor and integral bed support for a chromatography column. The flow distributor has an outlet extending through it and a bottom face across which is secured a bed support. The bottom face has a series of ribs extending radially outward from a center portion of the face. The bed support is secured to the flow distributor about its outer periphery and this amount of available surface area of the flow distributor and/or face that is used to secure the bed support is less than about 10%. A distribution disk is arranged over the inlet and extends across from about 1 to about 30% of the flow distributor's surface area, ending just short of the inner edge of the ribs closest to the center point of the flow distributor face. This disk is mounted on two or more legs so as to be of substantially the same height as the ribs. The disk projects the fluid flow in a 360° radial distribution without any noticeable partitioning.Type: GrantFiled: February 17, 2004Date of Patent: September 13, 2005Assignee: Millipore CorporationInventors: Michael Titus, Aaron Noyes, Ian Rayner, Chris Antoniou
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Publication number: 20040184957Abstract: The present invention is a flow distributor and integral bed support for a chromatography column. The flow distributor has an outlet extending through it and a bottom face across which is secured a bed support. The bottom face has a series of ribs extending radially outward from a center portion of the face. The bed support is secured to the flow distributor about its outer periphery and this amount of available surface area of the flow distributor and/or face that is used to secure the bed support is less than about 10%. A distribution disk is arranged over the inlet and extends across from about 1 to about 30% of the flow distributor's surface area, ending just short of the inner edge of the ribs closest to the center point of the flow distributor face. This disk is mounted on two or more legs so as to be of substantially the same height as the ribs. The disk projects the fluid flow in a 360° radial distribution without any noticeable partitioning.Type: ApplicationFiled: February 17, 2004Publication date: September 23, 2004Inventors: Michael Titus, Aaron Noyes, Ian Rayner, Chris Antoniou