Abstract: The present invention relates to novel compounds that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

Abstract: The invention relates to a device for the representation of tactile characters, in particular in Braille, comprising tactile elements which are combined in groups, wherein a tactile character consists in each case of a matrix of tactile points, which can be arranged in two adjacently arranged columns of points and at least two lines of points, wherein the four possible combinations of two tactile points of tactile points arranged adjacently in a line of points are in each case arranged on a common tactile element.

Abstract: The invention relates to a device for the representation of tactile characters, in particular in Braille, comprising tactile elements which are combined in groups, wherein a tactile character consists in each case of a matrix of tactile points, which can be arranged in two adjacently arranged columns of points and at least two lines of points, wherein the four possible combinations of two tactile points of tactile points arranged adjacently in a line of points are in each case arranged on a common tactile element.