Abstract: The present disclosure relates to nicotinamide adenine dinucleotide (oxidized form) preparations and the use of hygroscopic components to prevent decomposition of the nicotinamide adenine dinucleotide (oxidized form). These compounds can then be prepared and administered nasally, sublingually, vaginally, rectally and topically to the skin to serve as nutritional supplements, medical foods or drugs. These compounds can also be used in the manufacture of nicotinamide adenine dinucleotide (oxidized form) preparations in transdermal patches, and inhalation preparations.

Abstract: The present disclosure relates to nicotinamide adenine dinucleotide (oxidized form) preparations and the use of hygroscopic components to prevent decomposition of the nicotinamide adenine dinucleotide (oxidized form). These compounds can then be prepared and administered nasally, sublingually, vaginally, rectally and topically to the skin to serve as nutritional supplements, medical foods or drugs. These compounds can also be used in the manufacture of nicotinamide adenine dinucleotide (oxidized form) preparations in transdermal patches, and inhalation preparations.

Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.

Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.