Patents by Inventor Michael W. Deem
Michael W. Deem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11642665Abstract: This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.Type: GrantFiled: November 10, 2021Date of Patent: May 9, 2023Assignees: California Institute of Technology, William Marsh Rice UniversityInventors: Mark E. Davis, Stephen Kramer Brand, Joel E. Schmidt, Michael W. Deem
-
Publication number: 20220062875Abstract: This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.Type: ApplicationFiled: November 10, 2021Publication date: March 3, 2022Inventors: Mark E. Davis, Stephen Kramer Brand, Joel E. Schmidt, Michael W. Deem
-
Patent number: 11203013Abstract: This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.Type: GrantFiled: January 19, 2018Date of Patent: December 21, 2021Assignees: California Institute of Technology, William Marsh Rice UniversityInventors: Mark E. Davis, Stephen Kramer Brand, Joel E. Schmidt, Michael W. Deem
-
Publication number: 20180207625Abstract: This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.Type: ApplicationFiled: January 19, 2018Publication date: July 26, 2018Inventors: MARK E. DAVIS, STEPHEN KRAMER BRAND, JOEL E. SCHMIDT, MICHAEL W. DEEM
-
Publication number: 20170367692Abstract: The invention comprises a system, method, and apparatus for securing two ends of a ruptured or partially ruptured tendon in the hand or wrist during a repair, recession, or revision procedure. During this tenorrhaphy, anchoring material is inserted into the proximal ruptured surface of the tendon by an apparatus comprising multiple needles of at least two different types. Connecting material spans the site of tenorrhaphy of a ruptured tendon, or a multiplicity of ruptured tendons. In some embodiments, interlocking patterns of loop and helical suture are inserted by straight and helical needles, respectively.Type: ApplicationFiled: June 28, 2017Publication date: December 28, 2017Inventors: Michael W. DEEM, Kimberly M. NEELY, Forrest S. ROTH
-
Patent number: 9796596Abstract: A method is disclosed for synthesizing zeolite SSZ-52 in the presence of an organic structure directing agent having the following structure (1): wherein R1, R2, R3 and R4 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and n has a value of 0, 1 or 2.Type: GrantFiled: August 26, 2015Date of Patent: October 24, 2017Assignee: Chevron U.S.A. Inc.Inventors: Tianxiang Liu, Tracy Margaret Davis, Christopher Michael Lew, Dan Xie, Saleh Ali Elomari, Michael W. Deem
-
Publication number: 20170210684Abstract: A process is provided for the conversion of a hydrocarbon feedstock using catalyst system comprising one or more zeolites. The zeolites have been identified to be capable of selectively catalyzing the hydroisomerization reactions of linear or slightly branched long-chain hydrocarbons. Also provided is a method for the systematic discovery of zeolite framework types that are suitable for such conversion processes, according to a set of criteria: large affinity towards linear alkanes, high adsorption selectivity of linear over branched alkanes, and low adsorption selectivity of linear alkanes of different molecular weights.Type: ApplicationFiled: July 22, 2015Publication date: July 27, 2017Inventors: Joern Ilja Siepmann, Peng Bai, Michael Tsapatsis, Michael W. Deem
-
Publication number: 20160068402Abstract: A method is disclosed for synthesizing zeolite SSZ-52 in the presence of an organic structure directing agent having the following structure (1): wherein R1, R2, R3 and R4 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and n has a value of 0, 1 or 2.Type: ApplicationFiled: August 26, 2015Publication date: March 10, 2016Inventors: Tianxiang LIU, Tracy Margaret DAVIS, Christopher Michael LEW, Dan XIE, Saleh Ali ELOMARI, Michael W. DEEM
-
Publication number: 20160068403Abstract: A method is disclosed for preparing zeolite SSZ-52 using a computationally predicted organic structure directing agent. The computationally predicted structure organic directing agent is an organic structure directing agent other than an N,N-diethyl-5,8-dimethyl-azonium bicyclo[3.2.2.]nonane cation, and the difference in stabilization energy between the organic structure directing agent other than an N,N-diethyl-5,8-dimethyl-azonium bicyclo[3.2.2.]nonane cation and the N,N-diethyl-5,8-dimethyl-azonium bicyclo[3.2.2.]nonane cation is no more than 2.5 kJ mol?1 Si.Type: ApplicationFiled: August 26, 2015Publication date: March 10, 2016Inventors: Tianxiang LIU, Tracy Margaret DAVIS, Christopher Michael LEW, Dan XIE, Saleh Ali ELOMARI, Michael W. DEEM
-
Patent number: 8398992Abstract: The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.Type: GrantFiled: December 22, 2011Date of Patent: March 19, 2013Assignee: Polytopos LLCInventors: Michael W Deem, Jeong-Man Park, Hao Zhou
-
Publication number: 20120093864Abstract: The present invention relates to therapeutic and prophylactic methods for treating Or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site Of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.Type: ApplicationFiled: December 22, 2011Publication date: April 19, 2012Applicant: POLYTOPOS LLCInventors: Michael W. Deem, Jeong-Man Park, Hao Zhou
-
Patent number: 8110196Abstract: The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.Type: GrantFiled: April 29, 2005Date of Patent: February 7, 2012Assignee: Polytopas LLCInventors: Michael W. Deem, Jeong-Man Park, Hao Zhou
-
Patent number: 6673577Abstract: The present invention discloses a methodology which is directed to providing positive confirmation that nucleic acids, possessing putatively identified sequences predicted to generate observed GeneCalling™ signals, are actually present within the sample from which the signal was originally derived. The putatively identified nucleic acid fragment within the sample possesses 3′- and 5′-ends with known terminal subsequences. The method involves contacting nucleic acid fragments in a sample in amplifying conditions with (i) a nucleic acid polymerase; (ii) “regular” primer oligonucleotides having sequences comprising hybridizable portions of known terminal subsequences; and (iii) a “poisoning” oligonucleotide primer. Nucleic acids amplified with a poisoning primer are distinguishable upon detection from nucleic acids amplified with regular primers.Type: GrantFiled: November 14, 2000Date of Patent: January 6, 2004Assignee: CuraGen CorporationInventors: Jonathan M. Rothberg, Michael W. Deem, John W. Simpson
-
Patent number: 6640191Abstract: Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial chemistry; the combinatorial libraries generated and screened by such Monte Carlo methods; and an apparatus for generating and screening such libraries robotically. The process involves preparing a first set of samples, then changing the composition and non-composition variables of the samples using Monte Carlo sampling methods, and accepting proposed new samples according to a detailed balance acceptance criterion.Type: GrantFiled: December 30, 1999Date of Patent: October 28, 2003Assignee: The Regents of the University of CaliforniaInventors: Michael W. Deem, Marco Falcioni
-
Patent number: 6453245Abstract: This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.Type: GrantFiled: January 10, 2001Date of Patent: September 17, 2002Assignee: CuraGen CorporationInventors: Jonathan Marc Rothberg, Michael W. Deem, John W. Simpson
-
Patent number: 6432361Abstract: This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.Type: GrantFiled: November 28, 2000Date of Patent: August 13, 2002Assignee: CuraGen CorporationInventors: Jonathan Marc Rothberg, Michael W. Deem, John W. Simpson
-
Patent number: 6418382Abstract: This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.Type: GrantFiled: December 29, 2000Date of Patent: July 9, 2002Assignee: CuraGen CorporationInventors: Jonathan Marc Rothberg, Michael W. Deem, John W. Simpson
-
Publication number: 20020058256Abstract: This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.Type: ApplicationFiled: January 10, 2001Publication date: May 16, 2002Applicant: CuraGen CorporationInventors: Jonathan Marc Rothberg, Michael W. Deem, John W. Simpson
-
Patent number: 6341256Abstract: In a specific embodiment, this invention includes a method for determining an accurate, consensus pharmacophore structure shared by compounds that bind selectively to a target molecule. Optionally, the method begins with screening a diversity library against the target molecule of interest to pick the selectively binding members. Next the structure of the selected members is examined and a candidate pharmacophore responsible for the binding to the target molecule is determined. Next, preferably by REDOR nuclear magnetic resonance, several highly accurate interatomic distances are determined in certain of the selected members which are related to the candidate pharmacophore. A highly accurate consensus, configurational bias, Monte Carlo method determination of the structure of the candidate pharmacophore is made using the structure of the selected members and incorporating as constraints the shared candidate pharmacophore and the several measured distances.Type: GrantFiled: March 31, 1995Date of Patent: January 22, 2002Assignee: CuraGen CorporationInventors: Michael W. Deem, Jonathan Marc Rothberg, Gregory T. Went
-
Publication number: 20010007985Abstract: This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.Type: ApplicationFiled: December 29, 2000Publication date: July 12, 2001Applicant: CuraGen CorporationInventors: Jonathan Marc Rothberg, Michael W. Deem, John W. Simpson