Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: In some embodiments, a computer system applies a time of day setting to a virtual environment. In some embodiments, the time of day setting is updated based on an event. In some embodiments, a computer system displays content in an expanded display mode. In some embodiments, computer systems join a communication session while maintaining display of respective environments. In some embodiments, a computer system moves a portal based on user movement. In some embodiments, computer systems share a virtual environment. Computer systems can display media with simulated lighting. Computer systems can share an environment. In some embodiments, a computer system selects a position relative to content. A computer system can present representations of communication session participants based on content. A computer system can present user interfaces to control visual appearances of an environment including media. Computer systems can change an appearance of an environment based on environmental modes.

Abstract: A method and apparatus for removing grease from meat includes a mesh basket for holding the partially cooked meat, a pressure plate for exerting a sustained force on the meat within the mesh basket, one or more spacers for placing on top of the pressure plate, a container for holding the mesh basket with the one or more spacers partially extending beyond an opening in the container and a lid that can be pressed onto the container, sealing the opening and placing sustained force on the spacers, thereby placing sustained force on the pressure plate, thereby compressing the partially cooked meat and extracting grease and excess liquids from the meat through the mesh basket and into the bottom of the container. A handle is provided to hold the container so as to pour out the grease and excess liquids through a flow conducting member, perhaps a spout.