Patents by Inventor Michael W. Tusche

Michael W. Tusche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating toso activity
    Patent number: 10822388
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Opioid receptor antagonist prodrugs
    Patent number: 10544154
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 28, 2020
    Assignee: Nirsum Laboratories, Inc.
    Inventors: Michael W. Tusche, Nikej Shah
  • Opioid receptor antagonist prodrugs
    Patent number: 10538531
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 21, 2020
    Assignee: Nirsum Laboratories, Inc.
    Inventors: Michael W. Tusche, Nikej Shah
  • Opioid receptor antagonist prodrugs
    Patent number: 10533015
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 14, 2020
    Assignee: Nirsum Laboratories, Inc.
    Inventors: Michael W. Tusche, Nikej Shah
  • Opioid receptor antagonist prodrugs
    Patent number: 10525055
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 7, 2020
    Assignee: Nirsum Laboratories, Inc.
    Inventors: Michael W. Tusche, Nikej Shah, Mingping Ding, Qiang Han, Liangliang Ji
  • OPIOID RECEPTOR ANTAGONIST PRODRUGS
    Publication number: 20190308988
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 10, 2019
    Inventors: Michael W. Tusche, Nikej Shah
  • OPIOID RECEPTOR ANTAGONIST PRODRUGS
    Publication number: 20190308989
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 10, 2019
    Inventors: Michael W. Tusche, Nikej Shah
  • OPIOID RECEPTOR ANTAGONIST PRODRUGS
    Publication number: 20190307743
    Abstract: Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 10, 2019
    Inventors: Michael W. Tusche, Nikej Shah, Mingping Ding, Qiang Han, Liangliang Ji
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20180016320
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: May 1, 2017
    Publication date: January 18, 2018
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating toso activity
    Patent number: 9670265
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9624289
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 18, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Antibodies to Toso
    Patent number: 9493561
    Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 15, 2016
    Assignee: University Health Network
    Inventors: Tak W. Mak, Xiuqiu Lai, Michael W. Tusche
  • Methods and compositions for modulating Toso activity
    Patent number: 9321824
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 26, 2016
    Assignee: Universal Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Methods and compositions for modulating Toso activity
    Patent number: 9228006
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 5, 2016
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150299292
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 22, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150197551
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: July 16, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20150139995
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • ANTIBODIES TO TOSO
    Publication number: 20150010542
    Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Inventors: Tak W. Mak, Xiuqiu Lai, Michael W. Tusche
  • METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
    Publication number: 20130281356
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin