Abstract: The concepts described herein are directed to implementations of production facilities that can produce molecules used to treat biological conditions, such as biotherapeutics. The biotherapeutics can include various molecules, such as proteins, enzymes, and antibodies. The production facilities can include a number of separate modular cleanrooms that comprise particular pieces of equipment to perform one or more aspects of the processes used to manufacture biotherapeutics. The modular cleanrooms are arranged such that material that is produced by the equipment of one modular cleanroom can be transferred to another modular cleanroom for additional processing. Additionally, systems and processes are described to generate models using machine learning techniques, where the models can be used to predict productivity and/or efficiency metrics for production lines of biotherapeutics. Further, models can be generated to control the operation of pieces of equipment included in the production lines.

Abstract: A flow of ionizable gas is provided to a shielded plasma arc torch which includes an electrode, a translatable nozzle, a nozzle retainer, and a shield. After passing through a heat exchanger to cool the electrode, the gas flow enters an annular chamber where the flow is divided into three subflows. A first subflow enters a plasma chamber formed by the electrode, the nozzle, and a swirl ring to pressurize the plasma chamber and support a plasma arc. The second subflow passes serially through apertures in the nozzle retainer and the shield to shield the plasma arc. The remaining flow is vented to ambient. Accordingly, a single gas flow may be employed to independently support multiple torch operating requirements.