Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake

Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.

Abstract: The invention relates to a component (4) of a biosensor, comprising at least one first device (6) for receiving a sample liquid, wherein the device (6) is connected via a distributor channel (7) to further receiving devices (8 to 11), into each of which a feed channel (71, 72, 73, 74) branching off from the distributor channel (7) opens, and the feed channels (71, 72, 73, 74) are arranged in succession in flow direction (S) of the sample liquid passed on through the distributor channel (7). In accordance with the invention, it is envisaged that, in the distributor channel (7), in each case between two immediately successive feed channels (71, 72; 72, 73; 73, 74) in flow direction (S), at least one region (K) for at least temporary slowing or stoppage of the capillary flow of the sample liquid has been inserted.

Abstract: The present invention relates to a polymer composition containing polycarbonate with a weight-average molecular weight Mw of from 24,000 to 33,000 and 5.0 wt. % to 20.0 wt. % (based on the total amount of the composition) of glass hollow spheres with an alkalinity of less than 1.0 meq/g. The present invention furthermore provides coextruded sheets in which the coextruded layer contains this polymer composition, and shaped articles produced therefrom, in particular containers and pieces of luggage, very particularly suitcases. Sheets which are obtainable with the polymer composition according to the invention have a high mechanical stability, a high scratch resistance, pleasant haptic properties and an excellent homogeneous external visual impression. The present invention furthermore relates to a process for the preparation of these polymer compositions and a process for production of the sheets according to the invention.

Abstract: The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.

Abstract: The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.

Abstract: A method for testing a signal path of a first IC formed as a monolithically integrated circuit on a semiconductor body together with a magnetic field sensor and has a signal output and a power supply connection and a test mode state and a normal operating state. A power supply of the first IC is switched off, and a signal output is connected with a reference potential, and the power supply of the first IC is switched on and the signal output is disconnected from the reference potential. Subsequently in a test mode state, a self-test is performed in the first IC and a test pattern is configured at the signal output or at the power supply connection and the test pattern is evaluated by the control unit for testing of the signal path.

Abstract: A system and method for collaborative vehicle crash planning employs a model-based approach for mitigating damage and injuries resulting from a vehicle collision. A real-time crash model is generated to determine an optimal crash sequence within a parallel computing environment.

Abstract: A bracket (2) is provided for fastening to a bodyshell structure (6) of a motor vehicle. The bracket (2) is a bar that is bent to define first and second end sections (10, 28), first and second arcuate sections (11, 19) and a central section (18). The first end section (10) merges into the first arcuate section (11), the first arcuate section (11) merges into the central section (18), the central section (18) merges into the second arcuate section (19), and the second arcuate section (19) merges into a second end section (28). The end sections (10, 28) are parallel, and the central section (18) is perpendicular to the end sections (10, 28). Each arcuate section (11, 19) has plural partially arcuate sections (12, 14, 16, 20, 22, 24, 26), including one that is parallel to the central section (18).

Abstract: An input device for controlling a device is provided. The input device comprises a sensor surface sensitive to being touched by a foreign body, and an evaluation unit, which is equipped to sense the positions of successively touched points of the sensor surface, and convert them into a control command for the device. The evaluation unit is connected to means for estimating an acceleration acting on the sensor surface and equipped, when converting into the control command, to weight a point touched at a time of intense acceleration change lower than a point touched at a time of slight acceleration change.

Abstract: The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.

Abstract: The present invention relates to glucagon receptor agonists and their medical use, for example in the treatment of severe hypoglycemia.

Abstract: The present invention relates to organic coloring agents with a high color stability to weathering for thermoplastics. The invention furthermore relates to a polymer composition containing at least one thermoplastic and at least one organic coloring agent, preferably a combination of at least two organic coloring agents, of a specific structure. The invention moreover relates to the use of the coloring agents according to the invention for coloring polymer compositions, in particular for transparent formulations such as are required for the production of panes for use in buildings, motor vehicles and track vehicles or aircraft.

Abstract: The present invention relates to flameproofed, UV-resistant polycarbonate moulding compositions having improved flame retardancy and a low incorporation of the UV absorber into the polymer chain and a resulting higher relative viscosity compared with the polycarbonates having increased incorporation of UV absorber, wherein the polycarbonate compositions comprise A) at least one polycarbonate having an average molecular weight Mw of from 18,000 to 40,000 g/mol, B) one or more reactive UV absorbers and C) at least one alkali metal or alkaline earth metal salt of a fluorinated organic acid, and C) has a content of free sulfate of less than 0.007 wt. % and a content of free fluoride of less than 0.017 wt.%, in each case based on the weight of C).

Abstract: An aspect of the present disclosure is a receiver for receiving radiation from a heliostat array that includes at least one external panel configured to form an internal cavity and an open face. The open face is positioned substantially perpendicular to a longitudinal axis and forms an entrance to the internal cavity. The receiver also includes at least one internal panel positioned within the cavity and aligned substantially parallel to the longitudinal axis, and the at least one internal panel includes at least one channel configured to distribute a heat transfer medium.

Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.

Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists or optionally trigonal GLP-1/glucagon/GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.

Abstract: The present invention relates to exendin-4 peptide analogs and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.

Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.