Abstract: A machine implemented method and system, including: receiving at a near real-time processor module, one or more tenant-specific business objects from a message handler module; receiving at the near real-time processor module, contextual data related to the received one or more tenant-specific business objects from a platform analytics module; forming at the near real-time processor module, one or more events by applying one or more pre-defined analytic models to the received contextual data and the received one or more tenant-specific business objects; receiving at a message publisher module, one or more events from the near real-time processor module; and transmitting the received one or more events to one or more subscribers for the one or more events.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.

Abstract: Systems and methods for building passive and active electronics with diamond-like carbon (DLC) coatings are provided herein. DLC may be layered upon substrates to form various components of electronic devices. Passive components such as resistors, capacitors, and inductors may be built using DLC as a dielectric or as an insulating layer. Active components such as diodes and transistors may be built with the DLC acting substantially like a semiconductor. The amount of sp2 and sp3 bonded carbon atoms may be varied to modify the properties of the DLC for various electronic components.

Abstract: A method includes obtaining a speech signal. The method also includes predicting a first likelihood of a wake word or phrase being spoken in the speech signal using a first machine learning model trained to receive the speech signal as input. The method further includes, responsive to the first likelihood exceeding a first threshold, performing automatic speech recognition on the speech signal to determine a textual representation of the speech signal. The method also includes predicting a second likelihood of the wake word or phrase being spoken in the speech signal using a second machine learning model trained to receive at least one of the textual representation, audio features associated with the speech signal, and context features associated with the electronic device. In addition, the method includes, responsive to the second likelihood exceeding a second threshold, generating instructions to perform an action requested in the speech signal.

Abstract: A system for self-imaging a body portion includes a self-imaging device and an ancillary device that is attachable to the self-imaging device. The self-imaging device has a base member, a camera located within the base member and a guide element for transmitting light along a path extending between the camera and an exposed tip of the guide element that opens out of the self-imaging device at a given side of the device. The ancillary device is arranged to attach to the self-imaging device at said same given side while substantially not obstructing incoming light arriving towards the self-imaging device from being transmitted via the guide element towards the camera.

Abstract: A computer-implemented method for alerting passenger vehicles of approaching emergency vehicles is implemented by an alert management computing device. The method includes receiving an emergency vehicle alert request message from an emergency vehicle transmitter, receiving passenger vehicle location data from a plurality of passenger vehicle user computing devices located in a plurality of passenger vehicles, wherein the passenger vehicle location data includes a present passenger vehicle location and a present passenger vehicle trajectory, identifying an alert zone for the emergency vehicle based on the present emergency vehicle location and the present emergency vehicle trajectory, identifying a vehicle zone for each of the plurality of passenger vehicles, identifying a subset of the passenger vehicles within the alert zone by comparing each vehicle zone to the alert zone, and transmitting a warning to the subset of passenger vehicles via the passenger vehicle user computing devices.

Abstract: A method of preventing or reducing colour fade of fabrics over multiple laundry cycles wherein a composition comprising fabric softening active, pentaerythritol ester oil and perfume is used during the rinse stage of the laundry process. Method of preparing the composition.

Abstract: An implantable medical device with at least a portion of a wall thereof being coated to prevent fluid flow therethrough, and having one or more uncoated anti-migration features promoting tissue ingrowth therearound. The anti-migration features may be partially-closed or fully closed shapes forming a retention portion transverse to the direction along which migration forces typically impact the implantable medical device at the anatomical site at which the implantable medical device is to be deployed.

Abstract: A stent includes an expandable tubular body formed of one or more interwoven wires, and including a plurality of anti-migration features each having a first end fixed to the tubular body and a second end extending radially outward from an outer surface of the tubular body. The anti-migration features may be formed of a closed loop of one or more of the interwoven wires extending from the outer surface of the tubular body. The closed loops may be formed at the first end, the second end and/or along a medial region of the tubular body. In some instances, the base of the loops may be a cross-over point of the wire(s) forming the closed loop. The wire(s) may be welded at the cross-over point.

Abstract: Embodiments described herein provide a solution to the measurement of various dystrophins expressed in a cell or tissue. The solution to this problem is a specific and sensitive quantitative method to measure endogenous and/or exogenous dystrophin (e.g., engineered dystrophin) expression in skeletal muscle tissue, which provides a substantial benefit to drug development and monitoring of treatment.

Abstract: An esophageal stent may include an expandable framework having a first end, a second end, and a central longitudinal axis extending from the first end to the second end, the expandable framework being configured to expand from a radially collapsed configuration to a radially expanded configuration, and a polymeric outer sleeve disposed radially outward of and spaced apart from a body region of the expandable framework. The expandable framework may include a plurality of anti-migration supports extending radially outward from the body region of the expandable framework toward the polymeric outer sleeve.

Abstract: A speed square is provided including a triangular flat plate having measurement markings indicated on at least one face, a T bar affixed to, and extending along, the length of a first side of the triangular flat plate, and an extension element hingedly connected to an end of second side of the triangular flat plate opposite the T bar. The extension element having measurement markings indicated on at least one face, such that the measurement markings of the triangular flat face continue on the extension element.

Abstract: An illustrative stent includes an elongated tubular member comprising at least one strut or filament forming a tubular wall having a plurality of cells extending through a thickness of the tubular wall. The elongated tubular member may be configured to move between a radially collapsed configuration and a radially expanded configuration. A coating is disposed on the elongated tubular member and spanning the plurality of cells. The coating forms a pocket within at least some of the cells of the plurality of cells and extends radially inward of the tubular wall to define a void. In some instances, a partition or wall is positioned within at least some of the pockets and transects the void.

Abstract: An actuator component for a droplet ejection head; wherein said actuator component comprises a substrate and one or more strips of piezoelectric material fixedly attached to said substrate; wherein said one or more strips of piezoelectric material comprise one or more layers of piezoelectric material, and an array of fluid chambers defined within said one or more strips of piezoelectric material and extending in an array direction; wherein said actuator component further comprises one or more cover parts; wherein the or each cover part extends in said array direction and is fixedly attached to at least one of a side face of one of said strips of piezoelectric material and/or at least a portion of said substrate; and wherein said one or more cover parts comprise a plurality of openings so as to enable fluid to be supplied to selected ones of said fluid chambers through said openings. Associated methods of manufacturing an actuator component for a droplet ejection head are also provided.

Abstract: An endoprosthesis for implantation within a vessel lumen may include a tubular scaffold formed of one or more interwoven filaments, wherein the tubular scaffold is configured to shift between a radially collapsed configuration and a radially expanded configuration, a polymeric covering secured to the tubular scaffold, and an anti-migration element extending radially outward from the tubular scaffold. The anti-migration element extends helically along at least a portion of the length of the tubular scaffold in a first helical direction. The anti-migration element may include a wire extending along an outer surface of the tubular scaffold. The anti-migration element may include a second polymeric covering disposed over the wire.

Abstract: An esophageal stent may include an expandable framework having a first end, a second end, and a central longitudinal axis extending from the first end to the second end, the expandable framework being configured to expand from a radially collapsed configuration to a radially expanded configuration, and a polymeric outer sleeve disposed radially outward of and spaced apart from a body region of the expandable framework. The expandable framework may include a plurality of anti-migration supports extending radially outward from the body region of the expandable framework toward the polymeric outer sleeve.

Abstract: A computer-implemented method for alerting passenger vehicles of approaching emergency vehicles is implemented by an alert management computing device. The method includes receiving an emergency vehicle alert request message from an emergency vehicle transmitter, receiving passenger vehicle location data from a plurality of passenger vehicle user computing devices located in a plurality of passenger vehicles, wherein the passenger vehicle location data includes a present passenger vehicle location and a present passenger vehicle trajectory, identifying an alert zone for the emergency vehicle based on the present emergency vehicle location and the present emergency vehicle trajectory, identifying a vehicle zone for each of the plurality of passenger vehicles, identifying a subset of the passenger vehicles within the alert zone by comparing each vehicle zone to the alert zone, and transmitting a warning to the subset of passenger vehicles via the passenger vehicle user computing devices.

Abstract: An illustrative stent includes an elongated tubular member comprising at least one strut or filament forming a tubular wall having a plurality of cells extending through a thickness of the tubular wall. The elongated tubular member may be configured to move between a radially collapsed configuration and a radially expanded configuration. A coating is disposed on the elongated tubular member and spanning the plurality of cells. The coating forms a pocket within at least some of the cells of the plurality of cells and extends radially inward of the tubular wall to define a void. In some instances, a partition or wall is positioned within at least some of the pockets and transects the void.

Abstract: Example expandable stent designs are disclosed. An example expandable stent includes a tubular scaffold including an inner surface, an outer surface and a lumen extending therein. The expandable stent also includes an outer layer disposed along the outer surface of the tubular scaffold and a first preformed flap attached to the outer layer. Additionally, the preformed flap is configured to releasably engage a vessel wall when the stent is implanted therein.

Abstract: The invention provides a coupling device (1), for a ladder having a bore in a headstock (4) extending between a pair of spaced apart styles, the coupling device (1) comprising: an elongate support member (6) having a mounting region (8) and a working region (7), the mounting region (8) configured to be received within the bore of the ladder to engage therewith, the working region (7) being configured to protrude from the bore and to receive and support a plurality of utility modules; and a releasable detent (9) to secure the elongate support member (6) within the bore, wherein the mounting region (8) is restrained from rotational movement relative to the bore, and the releasable detent (9) prevents longitudinal and transverse movement between the elongate support member (6) and the bore. The coupling device (1) of the invention provides a flexible ladder assembly that is adaptable to variable work environments encountered at the top of a portable ladder when used for access and conducting work.