Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.

Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

Abstract: A system to process semiconductor wafers includes an end effector, a proximity sensor and a controller. The end effector may be adapted to handle a semiconductor wafer. The proximity sensor may be attached to the end effector and may output a first sensor signal if a distance between the end effector and an object separated from the end effector is less than or equal to a first predetermined distance. The controller is responsive to the first sensor signal to slow a movement of the end effector. The proximity sensor further outputs a second sensor signal if the distance between the end effector and the object is less than or equal to a second predetermined distance in which the second predetermined distance being less than the first predetermined distance. The controller is responsive to the second sensor signal to stop movement of the end effector.

Abstract: A system for an aircraft includes an engine bleed source of a gas turbine engine. The system also includes a means for chilling an engine bleed air flow from the engine bleed source to produce a chilled working fluid. The system further includes a means for providing the chilled working fluid for an aircraft use.

Abstract: A cryogenic cooling system for an aircraft includes a first air cycle machine, a second air cycle machine, and a means for collecting liquid air. The first air cycle machine is operable to output a cooling air stream based on a first air source. The second air cycle machine is operable to output a chilled air stream at a cryogenic temperature based on a second air source cooled by the cooling air stream of the first air cycle machine. An output of the second air cycle machine is provided to the means for collecting liquid air.

Abstract: A propulsion system includes an electric fan propulsion motor with a plurality of propulsion motor windings. The propulsion system also includes a means for controlling a flow rate of a working fluid through a cryogenic working fluid flow control assembly to the propulsion motor windings.

Abstract: A gas turbine engine rotor includes a rotor that provides a cooling cavity. The cooling cavity has a first chamber and a second chamber that are fluidly connected to one another by a passageway. At least one of the first and second rotor portions is configured to support a blade that is fluidly isolated from the cavity. A phase change material is arranged in the cavity. The phase change material is configured to be arranged in the first chamber in a first state and in the second chamber in the second state. The passageway is configured to carry the phase change material between the second and first chambers once changed between the first and second states.

Abstract: An example turbofan engine starting system includes a core nacelle housing a compressor and a turbine. The core nacelle is disposed within a fan nacelle. The fan nacelle includes a turbofan. A bypass flow path downstream from the turbofan is arranged between the two nacelles. A controller is programmed to manipulate the nozzle exit area to facilitate startup of the engine. In one example, manipulates the nozzle exit area using nozzles, in response to an engine shutdown condition. The nozzles open and close to adjust the nozzle exit area.

Abstract: A system to process semiconductor wafers includes an end effector, a proximity sensor and a controller. The end effector may be adapted to handle a semiconductor wafer. The proximity sensor may be attached to the end effector and may output a first sensor signal if a distance between the end effector and an object separated from the end effector is less than or equal to a first predetermined distance. The controller is responsive to the first sensor signal to slow a movement of the end effector. The proximity sensor further outputs a second sensor signal if the distance between the end effector and the object is less than or equal to a second predetermined distance in which the second predetermined distance being less than the first predetermined distance. The controller is responsive to the second sensor signal to stop movement of the end effector.

Abstract: The present disclosure relates generally to detection of contamination of a sample or diagnosis of subject based upon detection or quantification of amino acid sequences in a sample, specifically to the identification and use of molecular biomarkers for Candida albicans biofilm infections.

Abstract: The invention relates to a flywheel unit with a damping device for fastening the flywheel unit and a flywheel energy store. The flywheel unit comprises a rotor, a machine housing enclosing the rotor and with an underside, and a damping device fastened to the underside of the machine housing for fastening the flywheel unit to a suitable foundation, wherein the damping device comprises a lower stand unit for fastening to the foundation, an upper stand unit for fastening to the underside of the machine housing, and a membrane connecting the lower stand unit with the upper stand unit, wherein the upper and lower stand units as well as the membrane are configured in such away, that the membrane can establish a pliable self-supporting connection between the upper and lower stand units.

Abstract: A gas turbine engine comprises a plurality of fan rotors. A gas generator comprises at least one compressor rotor, at least one gas generator turbine rotor, a combustion section, and a fan drive turbine downstream of at least one gas generator turbine rotor. A shaft is configured to be driven by the fan drive turbine. The shaft engages gears to drive the plurality of fan rotors. A system controls the amount of power supplied to the plurality of fan rotors. A method of operating a gas turbine engine is also disclosed.

Abstract: The invention is related to compounds, which are GlyT1 inhibitors, for use in the treatment of hematological disorders, in particular for use in the treatment of sickle cell disease and thalassemia, or for the treatment of patients with iron overload syndromes, such as hereditary hemochromatosis.

Abstract: A gas turbine engine includes an accessory gearbox within an engine pylon. The accessory components may be mounted within the engine pylon to save weight and space within the core nacelle as well as provide a relatively lower temperature operating environment.

Abstract: The invention is related to compounds, which are GlyT1 inhibitors, for use in the treatment of hematological disorders, in particular for use in the treatment of sickle cell disease and thalassemia, or for the treatment of patients with iron overload syndromes, such as hereditary hemochromatosis.

Abstract: A gas turbine engine rotor includes a rotor that provides a cooling cavity. The cooling cavity has a first chamber and a second chamber that are fluidly connected to one another by a passageway. At least one of the first and second rotor portions is configured to support a blade that is fluidly isolated from the cavity. A phase change material is arranged in the cavity. The phase change material is configured to be arranged in the first chamber in a first state and in the second chamber in the second state. The passageway is configured to carry the phase change material between the second and first chambers once changed between the first and second states.

Abstract: An example turbofan engine starting system includes a core nacelle housing a compressor and a turbine. The core nacelle is disposed within a fan nacelle. The fan nacelle includes a turbofan. A bypass flow path downstream from the turbofan is arranged between the two nacelles. A controller is programmed to manipulate the nozzle exit area to facilitate startup of the engine. In one example, manipulates the nozzle exit area using nozzles, in response to an engine shutdown condition. The nozzles open and close to adjust the nozzle exit area.

Abstract: An example turbofan engine restarting system includes a core nacelle housing, a compressor, and a turbine. The core nacelle is disposed within a fan nacelle. A bypass flowpath downstream from the turbofan is arranged between the two nacelles. A controller is programmed to manipulate the nozzle exit area of the bypass flowpath to facilitate startup of the engine. In one example, the controller manipulates the nozzle exit area using hinged flaps in response to an engine shutdown condition. The flaps open and close to adjust the nozzle exit area and the associated bypass flow rate, the mass flow rate of the air through the core nacelle and the rotational speed of the compressor rotor.

Abstract: The present invention relates to a two part polyurethane and/or polyurethane polyurea hybrid based system for making an elastomeric material, comprising an Iso part having low free monomer and an amine/polyol part, wherein the Iso part comprises a pre-polymer of polyurethane, and wherein the pre-polymer is an MDI based pre-polymer with low free MDI monomer and capped with isocyanate groups from a second relatively higher vapor pressure isocyanate and the pre-polymer contains less than about 0.3% total free monomer and has an NCO % in the range of about 0.1 to about 10%.

Abstract: An apparatus for creating a musical composition comprising an audio interface, and audio converter module, and a multi-track compositor module is disclosed. The audio interface operably receives audio from an audio input device and outputting audio to an audio output device. The audio converter module is operably connected to the audio interface to convert audio received via the audio interface into an audio track having one or more partitions. The multi-track compositor module is configured to receive a first audio track and a second audio track and automatically score each partition of the first and second audio tracks based on one or more criteria. The multi-track compositor module is then configured to construct a third audio track from the partitions of the first and second audio tracks based on the scores for each partition. A method is also provided.