Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: Systems and methods for image generation include obtaining an input image and an attribute value representing an attribute of the input image to be modified; computing a modified latent vector for the input image by applying the attribute value to a basis vector corresponding to the attribute in a latent space of an image generation network; and generating a modified image based on the modified latent vector using the image generation network, wherein the modified image includes the attribute based on the attribute value.

Abstract: A system includes an article supply location, wherein the article supply location includes a plurality of articles to be sorted, first and second transport vehicles, each having a first position in which an article is stowed about the vehicle and a second position in which the article is deposited into a proximal container. And a control system. The control system is configured to receive an order for a plurality of disparate articles, determine one destination container of a plurality of destination containers to direct the transport vehicle to deposit a selected article, direct the first transport vehicle to transport a selected article to the destination container and deposit the article by manipulation of the first transport vehicle from the first position to the second position for deposit of the selected article in the destination container.

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: A rotor includes a rotor core lamination. The rotor core lamination includes a first metal alloy that at least partially defines adjacent magnet pockets proximate an outer periphery of the rotor core lamination. The rotor core lamination further includes a second metal alloy different than the first metal alloy that forms at least a portion of a bridge that extends between the magnet pockets. The rotor core lamination further includes permanent magnets disposed in the magnet pockets at opposing sides of the second metal alloy.

Abstract: In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in signal amplification. There are provided, in some embodiments, protease-based signal amplification modules. Disclosed herein include amplifier proteins comprising a first part of a first protease domain, a first dimerization domain, a first cut site a protease in a protease active state is capable of cutting, a second dimerization domain, a second cut site a protease in a protease active state is capable of cutting, and a first caging domain. Disclosed herein include companion amplifier proteins comprising a second part of a first protease domain, a third dimerization domain, a third cut site a protease in a protease active state is capable of cutting, a fourth dimerization domain, a fourth cut site a protease in a protease active state is capable of cutting, and a second caging domain.

Abstract: The present disclosure relates to anti-HIV antibodies and their use in the treatment or prevention of HIV/AIDS and in the development of HIV vaccines.

Abstract: Spectral data associated with one or more regions of a surface of a substrate is identified. The substrate has been processed according to one or more first operations of a process recipe that is unknown to a system controller for the manufacturing system. The spectral data is provided as input to a machine learning model that is trained to predict, based on given spectral data, a respective process recipe associated with the substrate and one or more operations of the respective process recipe that have already been performed. A determination is made, based on one or more outputs of the machine learning model, that the substrate is associated with the process recipe and that one or more second operations are yet to be performed. The substrate is caused to be processed according to the one or more second operations of the process recipe.

Abstract: Methods for determining stimulation for a patient having a stimulator device are disclosed. A model is received at an external system indicative of a range or volume of preferred stimulation parameters, which model is preferably specific to and determined for the patient. The external system receives a plurality of pieces of fitting information for the patient, including information indicative of a symptom of the patient, information indicative of stimulation provided by the stimulator device during a fitting procedure, and/or phenotype information for the patient. The external system determines one or more sets of stimulation parameters for the patient using the pieces of fitting information. In one example, training data is applied to the pieces of fitting information to select the one or more sets of stimulation parameters from the range or volume of preferred stimulation parameters in the model.

Abstract: A process mimicking forward modeler with deposition and erosion at each specific geological time step. The 3D derived properties are high resolution depositional environments and rock properties that are used to generate multiscale labelled synthetic data. These synthetic data can range from 1D logs such as grain size, gamma ray, density, and velocity, to 3D synthetic seismic, and are used directly as training data for various AIML applications.

Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: A method for forming a semiconductor device structure is disclosure. The method may include, depositing an NMOS gate dielectric and a PMOS gate dielectric over a semiconductor substrate, depositing a first work function metal over the NMOS gate dielectric and over the PMOS gate dielectric, removing the first work function metal over the PMOS gate dielectric, and depositing a second work function metal over the NMOS gate dielectric and over the PMOS gate dielectric. Semiconductor device structures including desired metal gate electrodes deposited by the methods of the disclosure are also disclosed.

Abstract: A measuring device for determining the density, the mass flow and/or the viscosity of a gas-charged liquid includes an oscillator, having a media-conducting measuring tube and two vibrational modes having media-density-dependent natural frequencies; an exciter for exciting the two vibrational modes; a vibrational sensor for detecting vibrations of the oscillator; and an operating and evaluating circuit to apply an excitation signal to the exciter, detect signals of the vibration sensor, determine current values of the natural frequencies of the two vibrational modes of the oscillator and fluctuations of the natural frequencies. The operating and evaluating circuit is designed to determine a first media state value, wherein the operating and evaluating circuit is furthermore designed to determine a second media state value which represents a gas charge of the medium.

Abstract: A polymeric blend contains a polyether block amide and a thermoplastic polymer, where the polyether block amide is based on a subunit 1 and a subunit 2. Subunit 1 is composed of at least one linear aliphatic diamine containing 5 to 15 carbon atoms and at least one linear aliphatic dicarboxylic acid containing 6 to 16 carbon atoms. Subunit 2 is composed of at least one polyether diol containing at least 3 carbon atoms per ether oxygen and primary OH groups at the chain ends. The sum total of the carbon atoms from diamine and dicarboxylic acid is an odd number and is 19 or 21 carbon atoms. The number-average molar mass of the subunit 2 is 200 to 900 g/mol. The thermoplastic polymer is selected from an ethylene/vinylene acetate, a thermoplastic polyester elastomer, a polyolefin elastomer, thermoplastic polyurethane, or any mixture thereof.