Patents by Inventor Michal Novak

Michal Novak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220402979
    Abstract: The disclosure provides immunogenic peptides, compositions, means, and methods for treating Alzheimer's disease or mild cognitive impairment. The disclosure further provides means and methods for diagnosing patients, selecting patients for treatment, and/or evaluating the efficacy of treatment for Alzheimer's disease or mild cognitive impairment.
    Type: Application
    Filed: September 8, 2020
    Publication date: December 22, 2022
    Inventors: Michal NOVAK, Eva KONTSEKOVÁ, Branislav KOVACECH, Norbert ZILKA
  • Patent number: 11319363
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment. Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 3, 2022
    Assignee: AXON NEUROSCIENCE SE
    Inventors: Michal Novak, Eva Kontsekova, Branislav Kovacech, Rostislav Skrabana
  • Publication number: 20220010004
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or pep tide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Application
    Filed: July 27, 2021
    Publication date: January 13, 2022
    Inventors: Michal NOVÁK, Eva KONTSEKOVÁ, Branislav KOVÁCECH, Norbert ZILKA
  • Patent number: 11098106
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: August 24, 2021
    Assignee: Axon Neuroscience SE
    Inventors: Michal Novák, Eva Kontseková, Branislav Kovácech, Norbert Zilka
  • Publication number: 20210009666
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment. Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Application
    Filed: July 10, 2020
    Publication date: January 14, 2021
    Inventors: Michal NOVAK, Eva KONTSEKOVA, Branislav KOVACECH, Rostislav SKRABANA
  • Patent number: 10745469
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment. Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: August 18, 2020
    Assignee: Axon Neuroscience SE
    Inventors: Michal Novak, Eva Kontsekova, Branislav Kovacech, Rostislav Skrabana
  • Publication number: 20190169276
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment. Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Application
    Filed: November 5, 2018
    Publication date: June 6, 2019
    Applicant: AXON NEUROSCIENCE SE
    Inventors: Michal Novak, Eva Kontsekova, Branislav Kovacech, Rostislav Skrabana
  • Patent number: 10160799
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: December 25, 2018
    Assignee: Axon Neuroscience SE
    Inventors: Michal Novak, Eva Kontsekova, Branislav Kovacech, Rostislav Skrabana
  • Publication number: 20180282401
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Application
    Filed: November 2, 1918
    Publication date: October 4, 2018
    Inventors: Michal Novák, Eva Kontseková, Branislav Kovácech, Norbert Zilka
  • Publication number: 20180142007
    Abstract: The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment Provided herein are humanized antibodies against human tau that are capable of discriminating between normal (healthy) and pathological (disease-associated) tau.
    Type: Application
    Filed: November 18, 2015
    Publication date: May 24, 2018
    Applicant: AXON NEUROSCIENCE SE
    Inventors: Michal NOVAK, Eva KONTSEKOVA, Branislav KOVACECH, Rostislav SKRABANA
  • Patent number: 9845352
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: December 19, 2017
    Assignee: AXON NEUROSCIENCE SE
    Inventors: Michal Novák, Eva Kontseková, Branislav Kováce{hacek over (c)}h, Norbert {hacek over (Z)}ilka
  • Patent number: 9828421
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: November 28, 2017
    Assignee: Axon Neuroscience SE
    Inventors: Michal Novák, Eva Kontseková, Branislav Kováce{hacek over (c)}h, Norbert {hacek over (Z)}ilka
  • Publication number: 20170260263
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 14, 2017
    Inventors: Michal NOVÁK, Eva KONTSEKOVÁ, Branislav KOVÁCECH, Norbert ZILKA
  • Publication number: 20170145082
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Application
    Filed: November 3, 2016
    Publication date: May 25, 2017
    Inventors: Michal NOVÁK, Eva KONTSEKOVÁ, Branislav KOVÁCECH, Norbert ZILKA
  • Patent number: 9518101
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 13, 2016
    Assignee: AXON NEUROSCIENCE SE
    Inventors: Michal Novak, Eva Kontseková, Branislav Kovácech, Norbert Zilka
  • Publication number: 20150050215
    Abstract: The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
    Type: Application
    Filed: September 14, 2012
    Publication date: February 19, 2015
    Applicant: Axon Neuroscience SE
    Inventors: Michal Novak, Eva Kontseková, Branislav Kovácech, Norbert Zilka
  • Publication number: 20090123936
    Abstract: The invention relates to antibodies with a specificity to an abnormally truncated form of tau protein, which is conformationally different from normal tau, and does not bind to normal tau protein, conformationally different tau proteins (“tauons”) and diagnostic and therapeutical aspects in relation to Alzheimer's disease and related tauopathies.
    Type: Application
    Filed: November 4, 2008
    Publication date: May 14, 2009
    Inventor: Michal Novak
  • Patent number: 7446180
    Abstract: Invention relates to antibodies with a specificity to an abnormally truncated form of tau protein which is conformationally different from normal tau and does not bind to normal tau protein, conformationally different tau proteins (“tauons”) and diagnostic and therapeutical aspects in relation to Alzheimer's disease and related tauopathies.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: November 4, 2008
    Assignee: Axon Neuroscience Forschungs-Und Entwicklungs GmbH
    Inventor: Michal Novak
  • Publication number: 20040082763
    Abstract: Invention relates to antibodies with a specificity to an abnormally truncated form of tau protein which is conformationally different from normal tau and does not bind to normal tau protein, conformationally different tau proteins (“tauons”) and diagnostic and therapeutical aspects in relation to Alzheimer's disease and related tauopathies.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 29, 2004
    Inventor: Michal Novak