Abstract: The invention relates to a recombinant novirhabdovirus expressing a chimeric protein comprising the sequence of an antigen of interest flanked, at the N-terminus, by a signal peptide, and at the C-terminus, by a polypeptide comprising at least one portion of the transmembrane domain of a rhabdovirus G protein. Said recombinant novirhabdovirus can be used especially for inducing an immune response to the antigen of interest.

Abstract: The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNAs are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

Abstract: The invention relates to a recombinant novirhabdovirus expressing a chimeric protein comprising the sequence of an antigen of interest flanked, at the N-terminus, by a signal peptide, and at the C-terminus, by a polypeptide comprising at least one portion of the transmembrane domain of a rhabdovirus G protein. Said recombinant novirhabdovirus can be used especially for inducing an immune response to the antigen of interest.

Abstract: A heat-activable powder adhesive composition for use in bonding a component to a surface such as glass is disclosed. The composition of the disclosed invention includes at least two polymers, at least one solid di- or poly-isocyanate in powder form, and a catalyst. Each of the two polymers has a melting point above 40° C. The two polymers are selected from the group consisting of di-functional polymers and multi-functional polymers. The preferred method of preparing the composition of the disclosed invention includes first forming three parts, including a first melted part comprising the polymers, a second melted part comprising the polymers and a catalyst, and a third part comprising the isocyanate. Once cooled, each of the first and second parts forms solid blocks which are fragmented and sieved. The three dry parts are then brought together to form the adhesive powder of the disclosed invention. The adhesive powder can be pre-applied to the attachment surface of a component to be bonded.

Abstract: The invention relates to recombinant novirhabdoviruses having at least one sequence encoding a polypeptide of interest added to their genome. Said recombinant novirhabdoviruses are useful as gene vectors, for producing recombinant proteins, or for producing vaccines for fish or for higher vertebrates.

Abstract: The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNAs are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

Abstract: The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

Abstract: A method and an apparatus are provided for the production of heat-activable adhesive pellets that can be formed into elements for holding an article to a surface such as a glass surface. The apparatus and method for the manufacture of the heat-activable pellets include the steps of introducing at least a first component comprising at least one difunctional polymer with at least one multifunctional polymer into an extruder, heating the first component, introducing a second component comprising isocyanate and a powder flow enhancer (such as fumed silica) at a point downstream of the introduction of the first component, combining the first and second components in the extruder to form a flowable compound, pelletizing the extruded compound exiting the extruder by cutting to form heat-activable adhesive pellets, and drying the pellets. In one embodiment of the disclosed invention a catalyst is applied to the pellets to form catalyst-coated heat-activable adhesive pellets.

Abstract: A salmonid alphavirus polypeptide comprising an epitope capable of inducing a virus neutralizing immune response, nucleic acids encoding the polypeptide, a vaccine comprising the polypeptide and a method of producing salmonid alphavirus neutralizing antibodies.

Abstract: A method and an apparatus are provided for the production of heat-activable adhesive pellets which can be formed into elements for holding an article to a surface such as a glass surface. The apparatus and method for the manufacture of the heat-activable pellets includes the steps of introducing at least a first component comprising at least one difunctional polymer with at least one Multifunctional polymer into an extruder, heating the first component, introducing a second component comprising isocyanate and a powder flow enhancer (such as fumed silica) at a point downstream of the introduction of the first component, combining the first and second components in the extruder to form a flowable compound, pelletizing the extruded compound exiting the extruder by cutting to form heat-activable adhesive pellets, and drying the pellets. In one embodiment of the disclosed invention a catalyst is applied to the pellets to form catalyst-coated heat-activable adhesive pellets.

Abstract: A device for displaceably holding a glass pane (1) in a sliding rail has at least one fastening part (2) to which a hot-melt adhesive cushion (7) is fitted and which has at least one locking element (10, 11). Furthermore, there is an elongate holding rail (3) which can be brought into engagement with the or each locking element (10, 11). The or each locking element (10, 11) can be moved between a locking position, in which the or each fastening part (2) is connected fixedly to the holding rail (3), and a release position in which the engagement with the holding rail (3) is released and the glass pane (1) can be removed from the holding rail (3). As a result, repair due to wear of the holding rail (3) is less cost-intensive, since the glass pane (1) is connected releasably to the holding rail (3).

Abstract: A heat-activable powder adhesive composition for use in bonding a component to a surface such as glass is disclosed. The composition of the disclosed invention includes at least two polymers, at least one solid di- or poly-isocyanate in powder form, and a catalyst. The two polymers each have a melting point above 40° C. and are selected from the group consisting of di-functional polymers and multi-functional polymers. The preferred method of preparing the composition of the disclosed invention includes first forming three parts, including a first melted part comprising the polymers, a second melted part comprising the polymers and a catalyst, and a third part comprising the isocyanate. Once cooled, each of the first and second parts forms solid blocks which are fragmented and sieved. The three dry parts are then brought together to form the adhesive powder of the disclosed invention. The adhesive powder can be pre-applied to the attachment surface of a component to be bonded.

Abstract: A salmonid alphavirus polypeptide comprising an epitope capable of inducing a virus neutralizing immune response, nucleic acids encoding the polypeptide, a vaccine comprising the polypeptide and a method of producing salmonid alphavirus neutralizing antibodies.

Abstract: The invention concerns recombinant DNA's comprising c NDA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

Abstract: The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.

Abstract: The invention relates to recombinant novirhabdoviruses having at least one sequence encoding a polypeptide of interest added to their genome. Said recombinant novirhabdoviruses are useful as gene vectors, for producing recombinant proteins, or for producing vaccines for fish or for higher vertebrates.

Abstract: A fastening arrangement comprises a fastening element provided with a fastening portion having a planar outer side surface, and a hot-melt adhesive that can be melted in order to fasten the fastening element to a substrate. The fastening element is provided with a receiving recess that is open in the direction of the planar outer side surface. A retaining structure is provided in the region of the receiving recess. The hot melt adhesive is configured as a compact whose shape is adapted to the retaining structure such that the compact can be connected to the fastening element. The fastening arrangement can thus be prefabricated without incipient melting of the hot-melt adhesive.

Abstract: The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.

Abstract: The invention relates to a method for coating adhesive surfaces of fixing elements with a hot-melt adhesive, and to a device for carrying out said coating method. Base surfaces (5) of recesses (2) are formed by tappets (6), whereby the lateral walls thereof are displacably guided in the recesses (2). A displaceable container (9) which is used to fill up the adhesive powder in the recesses (2) is arranged next to the recesses (2). The side edges (10) of the container (9) cover a working plate (1). A slit (11) which is used to receive the securing element (4) is arranged on the other side of the recesses (2), said slit being provided with continuous holes (12) for the tappets (6). A pressure stamp (13) provided with a pressure plate (14) which is lowered onto the securing element (4) is arranged over the recesses (2). A heating station (15) which is used to heat the securing element prior to heating the recesses (2) to the desired heating temperature is arranged at a distance from the slits (11).

Abstract: A device for displaceably holding a glass pane (1) in a sliding rail has at least one fastening part (2) to which a hot-melt adhesive cushion (7) is fitted and which has at least one locking element (10, 11). Furthermore, there is an elongate holding rail (3) which can be brought into engagement with the or each locking element (10, 11). The or each locking element (10, 11) can be moved between a locking position, in which the or each fastening part (2) is connected fixedly to the holding rail (3), and a release position in which the engagement with the holding rail (3) is released and the glass pane (1) can be removed from the holding rail (3). As a result, repair due to wear of the holding rail (3) is less cost-intensive, since the glass pane (1) is connected releasably to the holding rail (3).