Patents by Inventor Michel I. P. M. Verhoeven

Michel I. P. M. Verhoeven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitric oxide-releasing metallic medical devices
    Patent number: 6887485
    Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: May 3, 2005
    Assignees: Medtronic Vascular, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Anthony L. Fitzhugh, Peiwen Cheng, Joseph Saavedra, Robert Cafferata, Marc Hendriks, Larry K. Keefer, Eugene Tedeschi, Michel I. P. M. Verhoeven
  • Nitric oxide-releasing metallic medical devices
    Publication number: 20010041184
    Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
    Type: Application
    Filed: May 25, 2001
    Publication date: November 15, 2001
    Inventors: Anthony L. Fitzhugh, Peiwen Cheng, Joseph Saavedra, Robert Cafferata, Marc Hendriks, Larry K. Keefer, Eugene Tedeschi, Michel I.P.M. Verhoeven