Patents by Inventor Michel Le Van Quyen

Michel Le Van Quyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11684303
    Abstract: A computer-implemented method for detecting pathological brain activity patterns from a scalp electroencephalographic signal, the method including the steps of obtaining (A) an electroencephalographic signal as a function of multiple channels and time; identifying (C), for each channel, the zero-crossings of the electroencephalographic signal over a fixed threshold; generating a zero-crossing representation of at least a segment of the obtained electroencephalographic signal with the identified zero-crossings; obtaining (D) a reference family of real functions of time and channels from a zero-crossing statistical analysis of zero-crossing representation of pre-recorded electroencephalographic signals; calculating (E) a matching score by comparing the zero-crossing representation of a segment of the electroencephalographic signal with at least one reference function from the reference family of functions; and computing the matching score as a function of time by sliding the at least one reference function from
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: June 27, 2023
    Assignees: Bioserenity, ICM (Institut Du Cerveau Et De La Moellle Épiniére), APHP (Assistance Publique—Hôpitaux De Paris), Centre National De La Recherche Scientifique, INSERM (Institut National De La Santé Et De La Recherche Médicale), Sorbonne Universite
    Inventors: Jan Pyrzowski, Michel Le Van Quyen, Jean-Eudes Le Douget
  • Patent number: 11642073
    Abstract: A system for calculating an indicator associated to a brain activity of a subject, the system including an acquisition module configured to acquire at least an epoch of electroencephalographic signal of a subject from a plurality of electrodes and a data processing module configured to carry out the steps of: calculating an average vector (VA) using as input of an autoencoder neural network (aNN) an electroencephalographic signals (ES) of a subject acquired from a plurality of electrodes; detecting (DET) the presence of at least a predefined pattern in the consecutive average values of the average vector (VA); and generating an indicator of brain activity (Idx) of the subject when detecting the predefined pattern.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 9, 2023
    Assignees: BIOSERENTIY, ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÈPINIÈRE, APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTTIFIQUE, INSERM (INSTITUT CENTRE NATIONAL DE LA RECHERCHE SCIENTTIFIQUE NATIONAI DF TA SANTÉ ET DF TA RECHERCHE MÉDICALE
    Inventors: Mohcine Heddi, Michel Le Van Quyen, Jean-Eudes Le Douget
  • Patent number: 11612743
    Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 28, 2023
    Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA ECHERCHE MEDICALE), SORBONNE UNIVERSITE
    Inventors: Michel Le Van Quyen, Stéphane Charpier, Séverine Mahon
  • Patent number: 11253674
    Abstract: An in-ear stimulation system including a first device configured to be worn at least partially in a first ear canal of a subject and a second device configured to be worn at least partially in a second ear canal of the subject. Each of the first device and the second device includes: at least one in-ear active electrode configured to receive a bio-signal and at least one in-ear reference electrode configured to receive a bio-signal; at least one stimulation device configured for emitting at least one electrical or sensory stimulus; and an electronic system configured to detect at least one bio-signal pattern from the bio-signals measured from the electrodes.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: February 22, 2022
    Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE)
    Inventors: Michel Le Van Quyen, Alexis Genin, Alexis Steiner, Mario Valderrama, Miguel Navarrete
  • Publication number: 20210093247
    Abstract: A computer-implemented method for detecting pathological brain activity patterns from a scalp electroencephalographic signal, the method including the steps of obtaining (A) an electroencephalographic signal as a function of multiple channels and time; identifying (C), for each channel, the zero-crossings of the electroencephalographic signal over a fixed threshold; generating a zero-crossing representation of at least a segment of the obtained electroencephalographic signal with the identified zero-crossings; obtaining (D) a reference family of real functions of time and channels from a zero-crossing statistical analysis of zero-crossing representation of pre-recorded electroencephalographic signals; calculating (E) a matching score by comparing the zero-crossing representation of a segment of the electroencephalographic signal with at least one reference function from the reference family of functions; and computing the matching score as a function of time by sliding the at least one reference function from
    Type: Application
    Filed: March 30, 2018
    Publication date: April 1, 2021
    Applicants: BIOSERENITY, ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), SORBONNE UNIVERSITE
    Inventors: Jan PYRZOWSKI, Michel LE VAN QUYEN, Jean-Eudes LE DOUGET
  • Publication number: 20210085236
    Abstract: A system for calculating an indicator associated to a brain activity of a subject, the system including an acquisition module configured to acquire at least an epoch of electroencephalographic signal of a subject from a plurality of electrodes and a data processing module configured to carry out the steps of: calculating an average vector (VA) using as input of an autoencoder neural network (aNN) an electroencephalographic signals (ES) of a subject acquired from a plurality of electrodes; detecting (DET) the presence of at least a predefined pattern in the consecutive average values of the average vector (VA); and generating an indicator of brain activity (Idx) of the subject when detecting the predefined pattern.
    Type: Application
    Filed: December 21, 2018
    Publication date: March 25, 2021
    Applicants: BIOSERENITY, ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÈPINIÈRE), APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Mohcine HEDDI, Michel LE VAN QUYEN, Jean-Eudes LE DOUGET
  • Publication number: 20200269045
    Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
    Type: Application
    Filed: January 24, 2020
    Publication date: August 27, 2020
    Inventors: Michel LE VAN QUYEN, Stéphane CHARPIER, Séverine MAHON
  • Patent number: 10561840
    Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: February 18, 2020
    Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Michel Le Van Quyen, Stéphane Charpier, Séverine Mahon
  • Publication number: 20190366033
    Abstract: An in-ear stimulation system including a first device configured to be worn at least partially in a first ear canal of a subject and a second device configured to be worn at least partially in a second ear canal of the subject. Each of the first device and the second device includes: at least one in-ear active electrode configured to receive a bio-signal and at least one in-ear reference electrode configured to receive a bio-signal; at least one stimulation device configured for emitting at least one electrical or sensory stimulus; and an electronic system configured to detect at least one bio-signal pattern from the bio-signals measured from the electrodes.
    Type: Application
    Filed: January 19, 2018
    Publication date: December 5, 2019
    Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Michel LE VAN QUYEN, Alexis GENIN, Alexis STEINER, Mario VALDERRAMA, Miguel NAVARRETE
  • Publication number: 20170368348
    Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
    Type: Application
    Filed: December 22, 2015
    Publication date: December 28, 2017
    Inventors: Michel LE VAN QUYEN, Stéphane CHARPIER, Séverine MAHON
  • Patent number: 7697979
    Abstract: A method for analyzing synchronizations of the electroencephalography of an individual using a set of sensors starting from cerebral electromagnetic analysis of the individual. The method creates a database by acquisition and digitization of electrophysiological signals output from the sensors, and calculates the degree of synchronization existing between all pairs of sensors recorded in an assembly protocol, in frequency bands between 0 and 2000 Hz, to build up the database of classes each characterizing a reference state. The method further performs statistical validation of a period analyzed in real time, which assigns this period to a class in the database, and detects a specific period with a determined degree of synchronization. A device implements this method.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: April 13, 2010
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jacques Martinerie, Michel Le Van Quyen, Jean-Philippe Lachaux, Bernard Renault
  • Publication number: 20090054800
    Abstract: The invention relates to a method of representing a dynamic functional image of the brain. It consists in acquiring (A) for a specific duration a plurality of electrophysiological signals {esi}1N of cerebral activity from a set of electrodes {Ei}1N placed on the scalp (S) of the subject, in locating (B) the set of neuroelectric generators {{right arrow over (g)}jk}11JK in the cerebral volume from a three-dimensional image {Ck}1K made up of successive cross-sections of the brain, and in applying the inverse problem, and within active zones that include neuroelectric generators discriminating (C) the amount of synchrony that exists between electrophysiological signal and neuroelectric generator pairs in a plurality of frequency bands, to detect groups of discriminating neural networks {RNdk}1K. The invention is useful for non-invasive study of provoked or unprovoked functional anomalies.
    Type: Application
    Filed: July 10, 2006
    Publication date: February 26, 2009
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
    Inventors: Jacques Martinerie, Sylvain Baillet, Line Garnero, Jean-Philippe Lachaux, Michel Le Van Quyen, Bernard Renault
  • Publication number: 20060015034
    Abstract: A method for analyzing synchronizations of the electroencephalography of an individual using a set of sensors starting from cerebral electromagnetic analysis of the individual. The method creates a database by acquisition and digitization of electrophysiological signals output from the sensors, and calculates the degree of synchronization existing between all pairs of sensors recorded in an assembly protocol, in frequency bands between 0 and 2000 Hz, to build up the database of classes each characterizing a reference state. The method further performs statistical validation of a period analyzed in real time, which assigns this period to a class in the database, and detects a specific period with a determined degree of synchronization. A device implements this method.
    Type: Application
    Filed: October 14, 2003
    Publication date: January 19, 2006
    Inventors: Jacques Martinerie, Michel Le Van Quyen, Jean-Philippe Lachaux, Bernard Renault
  • Patent number: 6507754
    Abstract: The invention concerns a device and a method for the detection of changes in dynamic properties of electrical brain activity to characterize and to differentiate between physiological and pathological conditions, or to anticipate epileptic seizures.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: January 14, 2003
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Michel Le Van Quyen, Jacques Martinerie, Francisco Varela, Michel Baulac
  • Patent number: 6442421
    Abstract: A method for the detection of changes in dynamic properties of brain electrical activity is used to characterize and differentiate between physiological and pathological conditions, and to anticipate epileptic seizures. The detection of changes in dynamic properties of brain electrical activity is accomplished by constructing reference dynamics (Sref) of a normal state from an EEG, comparing the reference dynamics (Sref) with dynamics of a test segment (St), and computing the similarities over the entire EEG recordings by sliding the test segment (St) periodically.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: August 27, 2002
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Michel Le Van Quyen, Jacques Martinerie, Francisco Varela, Michel Baulac
  • Publication number: 20020095099
    Abstract: The invention concerns a device and a method for the detection of changes in dynamic properties of electrical brain activity to characterize and to differentiate between physiological and pathological conditions, or to anticipate epileptic seizures.
    Type: Application
    Filed: January 17, 2002
    Publication date: July 18, 2002
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFICQUE
    Inventors: Michel Le Van Quyen, Jacques Martinerie, Francisco Varela, Michel Baulac