Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.

Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.

Abstract: A continuous process for making rigid PVC foam objects by extruding a preform from an initial PVC mixture, optionally cutting the preform into blanks, and expanding the preform or the blanks in water heated to a temperature above 70.degree. C. The initial mixture contains polyvinyl chloride, at least a first blowing agent capable of generating a gas, for example an isocyanate or a polyisocyanate, and at least one organic anhydride (and does not contain any added inert particles finely divided therein). The initial mixture may also contain less than one weight percent of a second blowing agent, for example azobisisobutyronitrile or azodicarbonamide. The objects produced possess heat- and sound-insulating properties.

Abstract: An improved process and apparatus for producing rigid cellular materials comprising polyvinyl chloride, wherein the controlled expansion of embryonic blocks obtained by molding, is carried out in a single expansion box closed throughout the whole duration of the expansion treatment, in several stages including pre-heating, pre-expanding and final expansion to the final dimensions of the block, the expansion box containing the block expanded to its final dimensions being then immersed in a bath of cold water for dimensional stabilization.The expansion box comprises at least two plates, with a frame attached to the lower face of each plate, to form, in use, a closed expansion box which is provided with a centering and holding mechanism to maintain the embryonic block in place within the expansion box, a device for opening and closing the expansion box being also provided, as well as a mechanism for transferring a plurality of expansion boxes assembled together from one bath to the other in succession.