Patents by Inventor Michelle Brusatori
Michelle Brusatori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11467139Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.Type: GrantFiled: August 9, 2019Date of Patent: October 11, 2022Assignee: Venica Fluid Sciences LimitedInventors: Gregory W. Auner, Michelle A. Brusatori, Ronald F. Johnson
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Patent number: 11375897Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.Type: GrantFiled: April 20, 2018Date of Patent: July 5, 2022Assignees: Henry Ford Health System, Wayne State UniversityInventors: Gregory William Auner, Michelle Brusatori, Steven N. Kalkanis, Lisa Scarpace
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Patent number: 11236379Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.Type: GrantFiled: February 25, 2019Date of Patent: February 1, 2022Assignees: Seraph Biosciences, Inc., Wayne State UniversityInventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
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Patent number: 11192104Abstract: A cartridge includes a substrate including a polymerase chain reaction (PCR) zone. The PCR zone includes a first heating region, a second heating region spaced away from the first heating region and a detection region. A microchannel is formed in the substrate. The microchannel receives a fluid flowing therethrough, the microchannel passing through the first heating region and second heating region to thermally cycle the fluid. The microchannel passes through the detection region after the fluid has been thermally cycled.Type: GrantFiled: November 9, 2018Date of Patent: December 7, 2021Assignee: Visca, LLCInventors: Gregory W. Auner, Michelle A. Brusatori, Changhe Huang
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Publication number: 20210187502Abstract: A cartridge includes a substrate including a polymerase chain reaction (PCR) zone. The PCR zone includes a first heating region, a second heating region spaced away from the first heating region and a detection region. A microchannel is formed in the substrate. The microchannel receives a fluid flowing therethrough, the microchannel passing through the first heating region and second heating region to thermally cycle the fluid. The microchannel passes through the detection region after the fluid has been thermally cycled.Type: ApplicationFiled: December 14, 2020Publication date: June 24, 2021Inventors: Gregory W. AUNER, Michelle A. Brusatori, Changhe HUANG
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Publication number: 20200261909Abstract: A cartridge includes a substrate including a polymerase chain reaction (PCR) zone. The PCR zone includes a first heating region, a second heating region spaced away from the first heating region and a detection region. A microchannel is formed in the substrate. The microchannel receives a fluid flowing therethrough, the microchannel passing through the first heating region and second heating region to thermally cycle the fluid. The microchannel passes through the detection region after the fluid has been thermally cycled.Type: ApplicationFiled: November 9, 2018Publication date: August 20, 2020Inventors: Gregory W. AUNER, Michelle A. Brusatori, Changhe HUANG
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Publication number: 20200138293Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.Type: ApplicationFiled: April 20, 2018Publication date: May 7, 2020Applicants: HENRY FORD HEALTH SYSTEM, WAYNE STATE UNIVERSITYInventors: Gregory William AUNER, Michelle BRUSATORI, Steven N. KALKANIS, Lisa SCARPACE
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Publication number: 20190369065Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.Type: ApplicationFiled: August 9, 2019Publication date: December 5, 2019Inventors: Gregory W. Auner, Michelle A. Brusatori, Ronald F. Johnson
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Patent number: 10488375Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.Type: GrantFiled: May 31, 2018Date of Patent: November 26, 2019Assignee: Venica Fluid Sciences LimitedInventors: Gregory W. Auner, Michelle A. Brusatori, Ronald F. Johnson
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Patent number: 10407653Abstract: A photobioreactor system includes vessel for containing a biomass and a plurality of illuminators which may have solid state devices embedded therein or coupled thereto. The light energy is distributed in the vessel volume by the illuminators so as to reach substantially all of the biomass being circulated in the vessel. Biomass may exit the top of the vessel and be refreshed with nutrients and liquid before being reintroduced at the bottom of the vessel. Carbon dioxide is introduced at the bottom of the vessel. The biomass may be agitated either ultrasonically or by motion of the illuminators. A source of energy for the light sources may be solar panels with battery storage and the carbon dioxide may be a byproduct of thermal power generation.Type: GrantFiled: January 30, 2014Date of Patent: September 10, 2019Assignee: Wayne State UniversityInventors: Gregory Auner, Michelle A. Brusatori, Joseph M. Smolinski, David J. Sant
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Publication number: 20190203255Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.Type: ApplicationFiled: February 25, 2019Publication date: July 4, 2019Applicants: Seraph Biosciences, Inc., Wayne State UniversityInventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
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Patent number: 10253346Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.Type: GrantFiled: August 7, 2014Date of Patent: April 9, 2019Assignees: Seraph Biosciences, Inc., Wayne State UniversityInventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
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Publication number: 20180348175Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.Type: ApplicationFiled: May 31, 2018Publication date: December 6, 2018Inventors: Gregory W. Auner, Michelle A. Brusatori, Ronald F. Johnson
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Patent number: 9778105Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a stairstep with a metalized surface, and a plurality of metalized stripes on a flat surface is disposed in a direction orthogonal to the long dimension of the stairsteps. The region between the flat surface and the stairstep is transparent. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.Type: GrantFiled: October 20, 2014Date of Patent: October 3, 2017Assignee: WAYNE STATE UNIVERSITYInventors: Gregory W. Auner, Changhe Huang, Christopher M. Thrush, Michelle Brusatori
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Publication number: 20160177366Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.Type: ApplicationFiled: August 7, 2014Publication date: June 23, 2016Applicants: SERAPH BIOSCIENCES, LLC, WAYNE STATE UNIVERSITYInventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
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Patent number: 9207122Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a plurality of alternating-slope stairsteps, wherein the portion of the step disposed parallel to the base of the diffraction grating is disposed so as to be orthogonal to the path of the scattered light from the second optical chain. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.Type: GrantFiled: January 31, 2013Date of Patent: December 8, 2015Assignee: WAYNE STATE UNIVERSITYInventors: Gregory Auner, Changhe Huang, Christopher M. Thrush, Michelle A. Brusatori
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Publication number: 20150085284Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a stairstep with a metalized surface, and a plurality of metalized stripes on a flat surface is disposed in a direction orthogonal to the long dimension of the stairsteps. The region between the flat surface and the stairstep is transparent. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.Type: ApplicationFiled: October 20, 2014Publication date: March 26, 2015Inventors: Gregory W. Auner, Changhe Huang, Christopher M. Thrush, Michelle Brusatori
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Publication number: 20150029504Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a plurality of alternating-slope stairsteps, wherein the portion of the step disposed parallel to the base of the diffraction grating is disposed so as to be orthogonal to the path of the scattered light from the second optical chain. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.Type: ApplicationFiled: January 31, 2013Publication date: January 29, 2015Applicant: WAYNE STATE UNIVERSITYInventors: Gregory Auner, Changhe Huang, Christopher M. Thrush, Michelle A. Brusatori
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Publication number: 20140212954Abstract: A photobioreactor system includes vessel for containing a biomass and a plurality of illuminators which may have solid state devices embedded therein or coupled thereto. The light energy is distributed in the vessel volume by the illuminators so as to reach substantially all of the biomass being circulated in the vessel. Biomass may exit the top of the vessel and be refreshed with nutrients and liquid before being reintroduced at the bottom of the vessel. Carbon dioxide is introduced at the bottom of the vessel. The biomass may be agitated either ultrasonically or by motion of the illuminators. A source of energy for the light sources may be solar panels with battery storage and the carbon dioxide may be a byproduct of thermal power generation.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Inventors: Gregory Auner, Michelle A. Brusatori, Joseph M. Smolinski, David J. Sant