Patents by Inventor Michelle Grilley
Michelle Grilley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9669044Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.Type: GrantFiled: May 19, 2014Date of Patent: June 6, 2017Assignee: Utah State UniversityInventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
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Publication number: 20140256665Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.Type: ApplicationFiled: May 19, 2014Publication date: September 11, 2014Applicant: UTAH STATE UNIVERSITYInventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
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Publication number: 20060014673Abstract: The present invention is directed to kappaA (?A) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The ?A conopeptides include unglycosylated and O-glycosylated peptides.Type: ApplicationFiled: July 6, 2005Publication date: January 19, 2006Applicants: Cognetix, Inc., University of Utah Research FoundationInventors: Richard Layer, Karen Pemberton, Robert Jones, James Garrett, Baldomero Olivera, J. McIntosh, David Hillyard, Michelle Grilley, Maren Watkins, Ameurfina Santos, Glenn Zafaralla, A. Craig
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Publication number: 20050214213Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: April 4, 2005Publication date: September 29, 2005Applicants: University of Utah, CognetixInventors: Baldomero Olivera, J. McIntosh, Maren Watkins, James Garrett, Lourdes Cruz, Michelle Grilley, Robert Schoenfeld, Craig Walker, Reshma Shetty, Robert Jones
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Publication number: 20030181368Abstract: The present invention is directed to kappaA (&kgr;A) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The &kgr;A conopeptides include unglycosylated and O-glycosylated peptides.Type: ApplicationFiled: May 7, 2002Publication date: September 25, 2003Inventors: Richard T. Layer, Karen E. Pemberton, Robert M. Jones, James L. Garrett, Baldomero M. Olivera, J. Michael McIntosh, David R. Hillyard, Michelle Grilley, Maren Watkins, Ameurfina D. Santos, Glenn Zafaralla, A. Grey Craig
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Publication number: 20030109670Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: February 11, 2002Publication date: June 12, 2003Applicant: University of Utah Research FoundationInventors: Baldomero M. Olivera, J. Michael McIntosh, Maren Watkins, James E. Garrett, Lourdes J. Cruz, Michelle Grilley, Robert A. Schoenfeld, Craig S. Walker, Reshma P. Shetty, Robert M. Jones
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Patent number: 6153738Abstract: The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1 is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val.Type: GrantFiled: December 21, 1999Date of Patent: November 28, 2000Assignee: University of Utah Research FoundationInventors: Richard Jacobsen, Elsie Jimenez, Lourdes J. Cruz, Baldomero M. Olivera, William R. Gray, Michelle Grilley, Maren Watkins, David R. Hillyard
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Patent number: 6077934Abstract: The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1, is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val.Type: GrantFiled: April 16, 1998Date of Patent: June 20, 2000Assignee: University of Utah Research FoundationInventors: Richard Jacobsen, Elsie Jimenez, Lourdes J. Cruz, Baldomero M. Olivera, William R. Gray, Michelle Grilley, Maren Watkins, David R. Hillyard
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Patent number: 5672682Abstract: A new peptide, .kappa.-conotoxin PVIIA, is disclosed. This peptide is found naturally in the cone snail Conus purpurascens and has the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser-Arg-Ly s-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val (SEQ ID NO:1) where Xaa represents 4-trans-hydroxyproline hydroxyproline or proline. This peptide together with a previously disclosed peptide, .delta.-conotoxin PVIA, act synergistically to rapidly immobilize fish which are injected with the two peptides. Injection of .kappa.-conotoxin PVIIA alone results in different symptoms with an injected fish becoming hyperactive and then contracting and suddenly extending all major fins. This "fin-popping" occurs repeatedly resulting in a series of jerky movements, but injection of only .kappa.-conotoxin PVIIA does not immobilize or kill the fish.Type: GrantFiled: March 18, 1996Date of Patent: September 30, 1997Assignee: University of Utah Research FoundationInventors: Heinrich Terlau, Ki-Joon Shon, Michelle Grilley, Baldomero M. Olivera