Abstract: The present disclosure describes a computer implemented method, a system, and a computer program product of measuring quality attributes of a virus sample. In an embodiment, the method, system, and computer program product include (1) receiving light scattering (LS) data from a light scattering detector analyzing separations of a virus sample, dRI data, and UV data, (2) receiving a molecular weight of a protein component of the sample, Mprotein (expected), a refractive index increment of the protein component, (dn/dc)protein, a refractive index increment of a DNA component of the sample, (dn/dc)DNA, and an extinction coefficient of the protein component, ?protein, (3) calculating a protein fraction of the sample, xprotein, with respect to the LS data, the dRI data, the Mprotein (expected), the (dn/dc)protein, the (dn/dc)DNA, and an optical constant, K, (4) calculating a DNA extinction coefficient of the sample, ?DNA, and (5) calculating quality attribute values of the sample.

Abstract: The present invention relates to Polysaccharide Size-Reduction Monitoring Methods useful for the non-invasive, and accurate monitoring of the progress of a polysaccharide size-reduction process.

Abstract: The present disclosure describes a computer implemented method, a system, and a computer program product of calculating molar mass values of components of and molar concentration values of conjugate molecules/particles.

Abstract: The present disclosure describes an apparatus, method, and system of measuring attributes of a viral gene delivery vehicle sample via separation. In an embodiment, the method, system, and computer program product include executing a set of logical operations analyzing a viral gene delivery vehicle sample on a set of analytical instruments, where the set includes at least one separation instrument, at least one static light scattering instrument, and at least two concentration detectors, resulting in a capsid protein mass of the sample, mA, a modifier mass of the sample, mB, and a modifier molar mass of the sample, MB, receiving a capsid protein molar mass of the sample, MA, from a capsid protein molar mass data source, receiving an injection volume of the sample, v, from an injection volume data source, and executing a set of logical operations calculating a total VGDV particle concentration of the sample, CA.

Abstract: A new type of asymmetric flow field flow fractionator, A4F, is described permitting improved sample fractionation means by providing a range of available channel lengths within the same A4F unit. With such an apparatus, samples may be optimally separated by performing such fractionations as a function of channel length. The ability to vary channel length within the same A4F unit has heretofore been unavailable.

Abstract: A new type of asymmetric flow field flow fractionator, A4F, is described permitting improved sample fractionation means by providing a range of available channel lengths within the same A4F unit. With such an apparatus, samples may be optimally separated by performing such fractionations as a function of channel length. The ability to vary channel length within the same A4F unit has heretofore been unavailable.