Patents by Inventor Michelle Lorraine Gradley

Michelle Lorraine Gradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11913048
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: February 27, 2024
    Assignee: BASF SE
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 11905538
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: February 20, 2024
    Assignee: BASF SE
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20230265472
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: March 6, 2023
    Publication date: August 24, 2023
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 11732281
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: August 22, 2023
    Assignee: BASF SE
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 11560577
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: January 24, 2023
    Assignee: BASF SE
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20220064680
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2 -amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 3, 2022
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20210395790
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: September 2, 2021
    Publication date: December 23, 2021
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20200385767
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 10, 2020
    Applicant: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 10781465
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: September 22, 2020
    Assignee: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley, Annette Alcasabas
  • Publication number: 20190185889
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: February 27, 2019
    Publication date: June 20, 2019
    Applicant: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley, Annette Alcasabas
  • Patent number: 10260078
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: April 16, 2019
    Assignee: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20180030487
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: October 18, 2017
    Publication date: February 1, 2018
    Applicant: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 9834802
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: December 5, 2017
    Assignee: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Publication number: 20170253897
    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 7, 2017
    Applicant: AgriMetis, LLC
    Inventors: Brian Michael Green, Michelle Lorraine Gradley
  • Patent number: 8198054
    Abstract: This disclosure relates to the synthesis of the compound of formula (I) according to Scheme A below: in which R1, R2 and R3, which may be identical or different, represent, individually and independently, an alkyl group, characterized by an enzymatic hydrolysis reaction that involves placing the compound of formula (II) in contact with an enzyme that performs a chemoselective hydrolysis of only one of the two ester functions of the compound of formula (II) to obtain the compound of formula (I).
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 12, 2012
    Assignees: Zach System, Novacta Biosystem Limited
    Inventors: Alain Burgos, Jean-Claude Caille, Michelle Lorraine-Gradley
  • Publication number: 20100068770
    Abstract: The invention relates to a synthesis process. This process relates to the synthesis of the compound of formula (I) according to Scheme A below: in which R1, R2 and R3, which may be identical or different, represent, individually and independently, an alkyl group, characterized by an enzymatic hydrolysis reaction that involves placing the compound of formula (II) in contact with an enzyme that performs a chemoselective hydrolysis of only one of the two ester functions of the compound of formula (II) to obtain the compound of formula (I). The invention allows the industrial preparation of the intermediate of formula (I), which may be used for the preparation of the pharmaceutical active principle repaglinide.
    Type: Application
    Filed: January 22, 2008
    Publication date: March 18, 2010
    Applicants: ZACH SYSTEM, NOVACTA BIOSYSTEMS LIMITED
    Inventors: Alain Burgos, Jean-Claude Caille, Michelle Lorraine Gradley
  • Patent number: 6844019
    Abstract: Flavor components, particularly for a vanilla composition, are produced by essentially natural methods employing biotransformation of plant-derived materials. Ferulic acid, a component of many plant cell walls, may be converted into vanillin, directly or indirectly. A plurality of such compounds may undergo bioconversions to produce components of a flavor composition.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: January 18, 2005
    Assignee: Zylepsis Limited
    Inventors: Peter Samuel James Cheetham, Michelle Lorraine Gradley, John Thomas Sime
  • Publication number: 20030185956
    Abstract: A method for extracting one or more desired components from an aqueous phase comprising a mixture comprising one or more further components, comprises separating the aqueous mixture (3) from a water-immiscible hydrophobic phase (2) by means of a hydrophilic membrane (1) and allowing the desired components to move out off the aqueous phase through the membrane and into the hydrophobic phase. The further components have a lower water solubility than the desired component(s), whereby the further components are substantially incapable of passing through the membrane. The method may be used for the isolation of materials from reaction mixtures for purification purposes or for the preparation of extracts of natural substances. Extracts can be produced by the method. Extracts may be produced in the form of carrier based flavours, for instance absorbed on paper or maltodextrins, or encapsulated into maltodextrins, including into glass forms; which can then be formed into powders or tablets and used as such.
    Type: Application
    Filed: May 29, 2003
    Publication date: October 2, 2003
    Inventor: Michelle Lorraine Gradley
  • Publication number: 20030176508
    Abstract: A composition of ferulic acid and ethylguaiacol or vinylguaiacol (preferably as the free compounds, optionally as salts or derivatives) shows synergistic antimicrobial properties and may be used in personal care products.
    Type: Application
    Filed: February 11, 2003
    Publication date: September 18, 2003
    Inventors: Peter Samuel James Cheetham, Michelle Lorraine Gradley
  • Patent number: 6054490
    Abstract: The invention relates to the use of a sesquiterpene for inhibiting an oxidative enzyme, preferably a cytochrome P450 enzyme. The invention also relates to compositions comprising a sesquiterpene and a drug which exhibits instability in the presence of an oxidative enzyme.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: April 25, 2000
    Assignee: Zylepsis Limited
    Inventors: John Thomas Sime, Peter Samuel James Cheetham, Michelle Lorraine Gradley, Nigel Eric Banister