Patents by Inventor Michelle Till

Michelle Till has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
    Patent number: 5843640
    Abstract: In one aspect, the present invention provides an in situ process of simultaneously detecting a specific predetermined nucleic acid sequence and a specific predetermined cellular antigen in the same cell. In accordance with that process, the antigen is labeled with a biotin- or DNP-tagged antibody that specifically immunoreacts with the antigen, the specific nucleic acid sequences in the cell are amplified, the amplified nucleic acid sequences are labeled with a fluorescently-tagged nucleic acid probe that specifically hybridizes to the amplified nucleic acid sequences, and the labeled nucleic acid sequences and labeled cellular antigen are detected.
    Type: Grant
    Filed: August 30, 1995
    Date of Patent: December 1, 1998
    Assignee: Northwestern University
    Inventors: Bruce Patterson, Steven Wolinsky, Michelle Till
  • Method of detecting amplified nucleic sequences in cells by flow cytometry
    Patent number: 5840478
    Abstract: The field of this invention is the detection and isolation of specific amplified DNA sequences by flow cytometry. More particularly, this invention relates to the detection of these specific amplified DNA sequences in cells so as to allow quantitation of viral burden of patients infected with a virus. The method is particularly adapted to detection of HIV-1 proviral DNA sequences and the assessment of activity of the virus in a cell.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: November 24, 1998
    Assignee: Northwestern University
    Inventors: Bruce Patterson, Michelle Till, Steven Wolinsky