Patents by Inventor Michiel Stork

Michiel Stork has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing outer membrane vesicles
    Patent number: 11542467
    Abstract: The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process wherein the spontaneous release of bacterial outer membrane vesicles (OMV) of Gram-negative bacteria is stimulated by application of a dissolved oxygen tension (DOT) that is higher than a physiological DOT. The thus produced OMVs are for use in vaccines. The invention further relates to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: January 3, 2023
    Assignee: Intravacc B.V.
    Inventors: Matthias Joannes Hendrikus Gerritzen, Leonardus Aldolfus van der Pol, Michiel Stork
  • An improved process for producing outer membrane vesicles
    Publication number: 20210238540
    Abstract: The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process wherein the spontaneous release of bacterial outer membrane vesicles (OMV) of Gram-negative bacteria is stimulated by application of a dissolved oxygen tension (DOT) that is higher than a physiological DOT. The thus produced OMVs are for use in vaccines. The invention further relates to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
    Type: Application
    Filed: December 4, 2018
    Publication date: August 5, 2021
    Applicant: De Staat der Nederlanden, vert, door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en
    Inventors: Matthias Joannes Hendrikus Gerritzen, Leonardus Aldolfus van der Pol, Michiel Stork
  • VACCINE
    Publication number: 20190008943
    Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
    Type: Application
    Filed: June 18, 2018
    Publication date: January 10, 2019
    Inventors: Jan POOLMAN, Nathalie Isabelle DEVOS, Michiel STORK, Johannes Petrus Maria TOMMASSEN, Vincent WEYNANTS
  • VACCINE
    Publication number: 20170080075
    Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
    Type: Application
    Filed: April 28, 2016
    Publication date: March 23, 2017
    Inventors: Jan POOLMAN, Nathalie Isabelle DEVOS, Michiel STORK, Johannes Petrus Maria TOMMASSEN, Vincent WEYNANTS
  • VACCINE COMPRISING PROTEIN NMB0964 FROM NEISSERIA MENINGITIDIS
    Publication number: 20160243211
    Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.
    Type: Application
    Filed: January 7, 2016
    Publication date: August 25, 2016
    Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants
  • Vaccine
    Patent number: 9365624
    Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: June 14, 2016
    Assignees: GlaxoSmithKline Biologicals, S.A., Utrecht University
    Inventors: Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Nathalie Isabelle Devos, Vincent Weynants
  • Vaccine comprising protein NMB0964 from
    Patent number: 9259461
    Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: February 16, 2016
    Assignee: GlaxoSmithKline Biologicals, S.A.
    Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants
  • VACCINE
    Publication number: 20130004510
    Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
    Type: Application
    Filed: March 11, 2011
    Publication date: January 3, 2013
    Inventors: Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Nathalie Isabelle Devos, Vincent Weynants
  • Vaccine Comprising Protein NMB0964 From Neisseria Meningitidis
    Publication number: 20110189215
    Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
    Type: Application
    Filed: March 6, 2009
    Publication date: August 4, 2011
    Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants