Patents by Inventor Michihiko Suzuki
Michihiko Suzuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11773161Abstract: An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.Type: GrantFiled: April 9, 2021Date of Patent: October 3, 2023Assignee: KYOWA KIRIN CO., LTD.Inventors: Hikaru Miyagi, Michihiko Suzuki, Junichi Saito, Hidetsugu Asada, So Iwata
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Publication number: 20210309738Abstract: An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.Type: ApplicationFiled: April 9, 2021Publication date: October 7, 2021Applicant: KYOWA KIRIN CO., LTD.Inventors: Hikaru MIYAGI, Michihiko SUZUKI, Junichi SAITO, Hidetsugu ASADA, So IWATA
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Patent number: 11091545Abstract: An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.Type: GrantFiled: July 12, 2018Date of Patent: August 17, 2021Assignee: KYOWA KIRIN CO., LTD.Inventors: Hikaru Miyagi, Michihiko Suzuki, Junichi Saito, Hidetsugu Asada, So Iwata
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Publication number: 20200157211Abstract: An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.Type: ApplicationFiled: July 12, 2018Publication date: May 21, 2020Applicant: KYOWA KIRIN CO., LTD.Inventors: Hikaru MIYAGI, Michihiko SUZUKI, Junichi SAITO, Hidetsugu ASADA, So IWATA
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Patent number: 10378011Abstract: An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein X1 is an oxygen atom or the like, R1 is formula (IIA), wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like, or formula (IVA) wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like, or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease.Type: GrantFiled: September 2, 2013Date of Patent: August 13, 2019Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Fumikazu Shinohara, Asana Makino, Junichiro Yamamoto, Taiji Oashi, Michihiko Suzuki, Jun-ichi Saito, Takahiro Nakajima, Tomoyuki Nishikawa, Masayoshi Nakoji, Yuichi Takahashi
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Patent number: 10342819Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.Type: GrantFiled: March 3, 2015Date of Patent: July 9, 2019Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Fumikazu Shinohara, Asana Makino, Junichiro Yamamoto, Takahiro Nakajima, Taiji Oashi, Michihiko Suzuki, Jun-ichi Saito, Tomoyuki Nishikawa, Masayoshi Nakoji, Yuichi Takahashi, Yasuo Kouda
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Patent number: 10082266Abstract: A vehicle lamp 10 includes a lamp body 11, a sealing material 42, and a lens member 12 and a leg portion 41. A groove portion 31 is formed in the lamp body 11. The sealing material 42 is filled in the groove portion 31. The leg portion 41 is provided on the lens member 12. The leg portion 41 is inserted into the groove portion 31 to thereby fix the lamp body 11 and the lens member 12 together via the seal material 42. A narrow portion 51 is provided at a bottom side of the groove portion 31 and a wide portion 52 is provided at an opening 35 side of the groove portion 31. A gap of the wide portion 52 is wider than the gap of the narrow portion 51. The amount of sealing material 42 used in vehicle lamp 10 is limited while ensuring an easy assemblage.Type: GrantFiled: April 5, 2013Date of Patent: September 25, 2018Assignee: KOITO MANUFACTURING CO., LTD.Inventors: Hiroki Kosugi, Michihiko Suzuki, Tetsuya Kataoka, Tamaaki Sugiura
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Publication number: 20170354673Abstract: An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like), formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.Type: ApplicationFiled: March 3, 2015Publication date: December 14, 2017Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Takahiro NAKAJIMA, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO, Tomoyuki NISHIKAWA, Masayoshi NAKOJI, Yuichi TAKAHASHI, Yasuo KOUDA
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Patent number: 9475805Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: GrantFiled: May 26, 2015Date of Patent: October 25, 2016Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
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Publication number: 20150376611Abstract: The present invention provides an oligonucleotide having improved affinity for AGO2, and the like. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) {wherein X1 is an oxygen atom or the like, R1 is formula (IIA) (wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like) or formula (IVA) (wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like), or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like} at the 5? end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3.Type: ApplicationFiled: September 2, 2013Publication date: December 31, 2015Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO, Takahiro NAKAJIMA, Tomoyuki NISHIKAWA, Masayoshi NAKOJI, Yuichi TAKAHASHI
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Publication number: 20150291587Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: ApplicationFiled: May 26, 2015Publication date: October 15, 2015Inventors: Arata YANAGISAWA, Keiji UEHARA, Masahiro MATSUBARA, Kimihisa UENO, Michihiko SUZUKI, Takeshi KUBOYAMA, Keisuke YAMAMOTO, Tomohiro TAMURA
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Publication number: 20150117047Abstract: A vehicle lamp 10 includes a lamp body 11, a sealing material 42, and a lens member 12 and a leg portion 41. A groove portion 31 is formed in the lamp body 11. The sealing material 42 is filled in the groove portion 31. The leg portion 41 is provided on the lens member 12. The leg portion 41 is inserted into the groove portion 31 to thereby fix the lamp body 11 and the lens member 12 together via the seal material 42. A narrow portion 51 is provided at a bottom side of the groove portion 31 and a wide portion 52 is provided at an opening 35 side of the groove portion 31. A gap of the wide portion 52 is wider than the gap of the narrow portion 51. The amount of sealing material 42 used in vehicle lamp 10 is limited while ensuring an easy assemblage.Type: ApplicationFiled: April 5, 2013Publication date: April 30, 2015Applicant: KOITO MANUFACTURING CO., LTD.Inventors: Hiroki Kosugi, Michihiko Suzuki, Tetsuya Kataoka, Tamaaki Sugiura
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Publication number: 20140330004Abstract: An oligonucleotide, which has a nucleotide residue or a nucleoside residue represented by formula (I) at the 5? end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue via the oxygen atom at position 3, or the like; wherein X represents an oxygen atom or the like, R1 represents formula (II) wherein Y1 represents a nitrogen atom or the like, R5 represents halogen or the like, R6 and R7 may be the same or different, and each represents a hydrogen atom or the like, and R3 represents a hydrogen atom or the like.Type: ApplicationFiled: December 6, 2013Publication date: November 6, 2014Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Fumikazu SHINOHARA, Asana MAKINO, Junichiro YAMAMOTO, Taiji OASHI, Michihiko SUZUKI, Jun-ichi SAITO
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Publication number: 20140119042Abstract: Provided are a vehicular lamp in which a thermal strain in a welding portion of a lamp body and a front cover is suppressed and a thermal deformation during welding is suppressed and a method of manufacturing the same. The vehicular lamp includes a lamp housing configured by a lamp body and a front cover which is welded to the lamp body and has a front surface exposed to the outside. In the lamp body, a light absorption material is contained. In the front cover, a light absorption material is contained at least in a region including a welding portion. This light absorption material of the front cover has a lower heating effect than that of the lamp body.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Applicant: KOITO MANUFACTURING CO., LTD.Inventors: Yuji SAGESAKA, Michihiko SUZUKI
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Publication number: 20130267711Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: ApplicationFiled: June 3, 2013Publication date: October 10, 2013Inventors: Arata YANAGISAWA, Keiji UEHARA, Masahiro MATSUBARA, Kimihisa UENO, Michihiko SUZUKI, Takeshi KUBOYAMA, Keisuke YAMAMOTO, Tomohiro TAMURA
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Patent number: 8486980Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: GrantFiled: August 6, 2009Date of Patent: July 16, 2013Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
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Patent number: 8273444Abstract: A lamp design surface member is provided. The lamp design surface member includes a design surface having a decorative surface. Concave-convex portions and planar portions are formed together on the decorative surface. The concave-convex portions have a peak cross-sectional height Rt of 1 ?m or more and the planar portions have a peak cross-sectional height Rt smaller than 1 ?m. The planar portions are formed so that an area ratio of the planar portions to the decorative surface is in a range of 30% to 80%.Type: GrantFiled: August 10, 2010Date of Patent: September 25, 2012Assignee: Koito Manufacturing Co., Ltd.Inventors: Michihiko Suzuki, Akinori Yamamoto, Kenichi Matsunaga
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Patent number: 8242151Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.Type: GrantFiled: February 7, 2008Date of Patent: August 14, 2012Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
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Publication number: 20110201640Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: ApplicationFiled: August 6, 2009Publication date: August 18, 2011Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
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Publication number: 20110052876Abstract: A lamp design surface member is provided. The lamp design surface member includes a design surface having a decorative surface. Concave-convex portions and planar portions are formed together on the decorative surface. The concave-convex portions have a peak cross-sectional height Rt of 1 ?m or more and the planar portions have a peak cross-sectional height Rt smaller than 1 ?m. The planar portions are formed so that an area ratio of the planar portions to the decorative surface is in a range of 30% to 80%.Type: ApplicationFiled: August 10, 2010Publication date: March 3, 2011Applicant: KOITO MANUFACTURING CO., LTD.Inventors: Michihiko SUZUKI, Akinori YAMAMOTO, Kenichi MATSUNAGA