Patents by Inventor Middleton B. Floyd, Jr.

Middleton B. Floyd, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives
    Patent number: 4288630
    Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Middleton B. Floyd, Jr.
  • 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
    Patent number: 4288633
    Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Middleton B. Floyd, Jr.
  • 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives
    Patent number: 4288632
    Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Middleton B. Floyd, Jr.
  • 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
    Patent number: 4288629
    Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation inhibitors and bronchodilators.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester(ketoacid)-prostaglandins
    Patent number: 4283550
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: August 11, 1981
    Assignee: American Cyanamid
    Inventor: Middleton B. Floyd, Jr.
  • 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
    Patent number: 4281153
    Abstract: This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: January 17, 1980
    Date of Patent: July 28, 1981
    Assignee: American Cyanamid
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei Lai Chen
  • 1-Descarboxy-1-ketoester (ketoacid) prostaglandins
    Patent number: 4267361
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: May 12, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins
    Patent number: 4260805
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: April 7, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins
    Patent number: 4254278
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: March 3, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins
    Patent number: 4254275
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: March 3, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester(ketoacid)-prostaglandins
    Patent number: 4250323
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: February 10, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • 1-Descarboxy-1-ketoester(ketoacid)-protaglandins
    Patent number: 4250321
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: February 10, 1981
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-carbinol prostaglandins of the A, D, E and F series
    Patent number: 4250325
    Abstract: The invention described herein relates to novel 15-deoxy-16-hydroxy-16-ethynyl or 16-(1-propynyl) prostaglandins of E, F, D and A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl; R.sub.15 is selected from the group consisting of C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, phenyl and phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F or Cl, wherein R is an alkyl group.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: February 10, 1981
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
    Patent number: 4239900
    Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: December 16, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
    Patent number: 4239899
    Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: December 16, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4237316
    Abstract: This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: December 2, 1980
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Novel 11-alkoxy-9-keto (or hydroxy)-prostenoic acid derivatives and method for preparing same
    Patent number: 4236027
    Abstract: This disclosure describes certain 11-alkoxy-9-keto- (or hydroxy)-prostenoic acid derivatives useful as anti-microbial agents, hypotensive agents, anti-ulcer agents, or as intermediates.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: November 25, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss
  • 15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series
    Patent number: 4233453
    Abstract: This invention disclosed herein relates to pharmacologically active 15-deoxy-16-hydroxy prostaglandin derivatives of the E and F series wherein C.sub.16 is substituted with allenyl.These compounds are active as hypotensives, antisecretory, bronchodilating and fertility control agents.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: November 11, 1980
    Assignee: American Cyanamid Company
    Inventor: Middleton B. Floyd, Jr.
  • Novel vinyl-stannyl derivatives
    Patent number: 4233231
    Abstract: Vinylstannyl derivatives and the processes for their conversion to vinyliodides, vinylbromides and vinyllithium reagents. The vinylstannyl, vinyliodides, vinylbromide derivatives and vinyllithiums are useful as intermediates for the preparation of prostaglandin analogs.
    Type: Grant
    Filed: November 22, 1977
    Date of Patent: November 11, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Charles V. Grudzinskas, Sow-Mei L. Chen
  • 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
    Patent number: 4202989
    Abstract: This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: May 13, 1980
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, Charles V. Grudzinskas, Sow-Mei L. Chen