Abstract: Protein double-shell nanostructures comprising apoferritin for carrying cargo proteins of interest are provided. Such nanostructures can be used to increase rigidity of a cargo protein of interest to allow structures of small and flexible proteins to be determined by cryogenic-electron microscopy (cryo-EM). Recombinant vectors for producing protein double-shell nanostructures are also provided. The nanostructures described herein may find use in various applications in research and drug discovery.

Abstract: Methods of treating a subject for a bone marrow failure syndrome, e.g., DBA, are provided. Aspects of the methods include administering to the subject an effective amount of a Nemo-Like Kinase (NLK) inhibitor. Also provided are compositions that find use in practicing embodiment of the invention.

Abstract: Compounds and methods are provided for inhibiting a CREB-CBP protein-protein interaction in a sample. In some cases, the method includes modulating transcription of CREB in a cell that overexpresses CREB. Also provided are methods of inhibiting the proliferation of a cancer cell. The subject CREB transcription inhibitor compounds include a substituted salicylamide or a prodrug thereof. Methods of alleviating symptoms associated with cancer (e.g., Acute Myeloid Leukemia (AML) or Acute Lymphomblastic Leukemia (ALL)) in a subject in need thereof are also provided. Pharmaceutical compositions including the subject compounds find use in treating cancer. The subject compounds may be formulated or provided to a subject in combination with a second agent, e.g. an anticancer agent.

Abstract: Provided is a cassette-vibration isolation device that is easy to upkeep (maintain) and that can cause a heavy structure to rise during an earthquake. The device is provided with an upper base and a lower base that are arranged so that the bottom surface of the upper base faces the upper surface of the lower base; a cavity, which is formed between the upper base and the lower base, and the inside of which is filled with fluid; sealing members, which are provided in an attachable/detachable manner along the inner walls of the cavity, and which maintain the state wherein the cavity is filled with fluid; and a valve, which connects the cavity and a fluid-supply source, and which supplies fluid to the inside of the cavity. During an earthquake, the upper base can rise from the lower base due to the supply of fluid via the valve to the inside of the cavity.

Abstract: Provided is a cassette-vibration isolation device that is easy to upkeep (maintain) and that can cause a heavy structure to rise during an earthquake. The device is provided with an upper base and a lower base that are arranged so that the bottom surface of the upper base faces the upper surface of the lower base; a cavity, which is formed between the upper base and the lower base, and the inside of which is filled with fluid; sealing members, which are provided in an attachable/detachable manner along the inner walls of the cavity, and which maintain the state wherein the cavity is filled with fluid; and a valve, which connects the cavity and a fluid-supply source, and which supplies fluid to the inside of the cavity. During an earthquake, the upper base can rise from the lower base due to the supply of fluid via the valve to the inside of the cavity.