Patents by Inventor Miho Yano

Miho Yano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbonyl reductase, gene thereof and method of using the same
    Patent number: 7915022
    Abstract: The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: March 29, 2011
    Assignee: Kaneka Corporation
    Inventors: Noriyuki Kizaki, Miho Yano, Masashiro Funaki, Teruaki Takesue, Yoshihiko Yasohara, Souichi Morikawa, Takahisa Nakai, Michihiko Kataoka, Sakayu Shimizu
  • Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same
    Publication number: 20100317075
    Abstract: The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
    Type: Application
    Filed: July 20, 2010
    Publication date: December 16, 2010
    Applicant: KANEKA CORPORATION
    Inventors: NORIYUKI KIZAKI, MIHO YANO, MASAHIRO FUNAKI, TERUAKI TAKESUE, YOSHIHIKO YASOHARA, SOUICHI MORIKAWA, TAKAHISA NAKAI, MICHIHIKO KATAOKA, SAKAYU SHIMIZU
  • Carbonyl reductase, gene thereof and method of using the same
    Patent number: 7794993
    Abstract: The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: September 14, 2010
    Assignee: Kaneka Corporation
    Inventors: Noriyuki Kizaki, Miho Yano, Masahiro Funaki, Teruaki Takesue, Yoshihiko Yasohara, Souichi Morikawa, Takahisa Nakai, Michihiko Kataoka, Sakayu Shimizu
  • METHOD FOR PRODUCING OPTICALLY ACTIVE 2-(N-SUBSTITUTED AMINOMETHYL)-3-HYDROXYBUTYRIC ACID ESTER
    Publication number: 20090104671
    Abstract: The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides an efficient method for industrially producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters, in particular such compounds having the (2S,3R) configuration, which are useful as intermediates for the production of medicinal compounds, among others.
    Type: Application
    Filed: July 19, 2006
    Publication date: April 23, 2009
    Applicant: Kaneka Corporation
    Inventors: Yoshihiko Yasohara, Miho Yano, Shigeru Kawano, Noriyuki Kizaki
  • Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same
    Publication number: 20080261281
    Abstract: The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
    Type: Application
    Filed: August 1, 2005
    Publication date: October 23, 2008
    Applicant: Kaneka Corporation
    Inventors: Noriyuki Kizaki, Miho Yano, Masahiro Funaki, Teruaki Takesue, Yoshihiko Yasohara, Souichi Morikawa, Takahisa Nakai, Michihiko Kataoka, Sakayu Shimizu