Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: An asset modification device includes memory, an asset modification module, and operation modules. The memory stores limit tables and asset operational data. The asset modification module selects an asset to modify, a limit table regarding the asset, an operational module based on an entry in the limit table, and evaluation data. A specific task execution module of the selected operation module executes a specific task on asset operational data of the asset to produce a modified asset when an evaluation data filter of the selected operation module indicates that analysis of the evaluation data is favorable for modification of the asset via the specific task.

Abstract: A device includes a network interface module, memory, and a processing module. The memory stores limit tables regarding an asset and operational data regarding the asset. When an asset is to be modified, the processing module retrieves a limit table(s) and identifies time-varying and time-sensitive data and an operation therefrom. The processing module then receives, via the network interface module, the time-varying and time-sensitive data and analyzes it based on evaluation criteria in the limit table. When the analysis is favorable, the processing module triggers the operation. With the operation triggered, the processing module further analyzes the time-varying and time-sensitive data based on correlated evaluation criteria of the evaluation criteria. When the further analysis is favorable, the processing module activates the operation for execution up operational data regarding the asset such that the asset is modified.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.