Patents by Inventor Mikhail A. Podyminogin

Mikhail A. Podyminogin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
    Patent number: 6339147
    Abstract: Derivatized oligonucleotides (ODNs) are coupled to a solid support in improved yield resulting in a high density of coupled oligonucleotide per surface unit of the support, through a Schiff base type bond formed between an NH2 group attached either to the solid support or to the ODN and an aromatic aldehyde attached to the other of the solid support and the ODN. The preferred solid support-ODN conjugate is formed between semicarbazide groups attached to a glass surface and an aromatic aldehyde attached at either 3′, or 5′ end of an ODN or to an intermediate nucleotide of the ODN.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: January 15, 2002
    Assignee: Epoch Biosciences, Inc.
    Inventors: Eugeny Alexander Lukhtanov, Mikhail A. Podyminogin, Joel Hedgpeth