Patents by Inventor Miki Akamatsu

Miki Akamatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same
    Patent number: 6379660
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2− functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: April 30, 2002
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu
  • Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
    Patent number: 6200558
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2− functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: March 13, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu
  • O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof
    Patent number: 5688992
    Abstract: The present invention relates to non-phosphorus containing O-malonyltryrosyl compounds, derivatives thereof, uses of the O-malonyltryrosyl compounds in the synthesis of peptides, and O-malonyltryrosyl compound-containing peptides. The O-malonyltyrosyl malonyltyrosyl compounds and O-malonyltryrosyl compound-containing peptides of the present invention are uniquely stable to phosphotases, capable of crossing cell membranes, suitable for application to peptide synthesis of O-malonyltryrosyl compound-containing peptides, and amenable to prodrag defivatization for delivery into cells. The present invention also provides for O-malonyltryrosyl compound-containing peptides which exhibit inhibitory potency against binding interactions of receptor domains with phosphotyrosyl-containing peptide ligands.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: November 18, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Terrence R. Burke, Jr., Bin Ye, Miki Akamatsu, Hemanta K. Kole, Xinjian Yan, Peter R. Roller
  • Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
    Patent number: 5632981
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: May 27, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu