Patents by Inventor Mikiko Sodeoka
Mikiko Sodeoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11982612Abstract: Systems and methods for flow cytometry. The methods comprise: labeling cells of a sample with Raman tags; causing the sample to flow through a microfluidic channel of a flow cytometer through which a laser beam passes; detecting Raman signals emitted from the Raman tags while being illuminated by the laser beam; and determining characteristics of the cells based on the detected Raman signals.Type: GrantFiled: April 19, 2022Date of Patent: May 14, 2024Assignee: BaySpec, Inc.Inventors: Kotaro Hiramatsu, Ryo Nishiyama, Keisuke Goda, Kosuke Dodo, Shintaro Kawamura, Mikiko Sodeoka, Hideyusi Suzuki, Charlie Zhang, William Yang Terziyan
-
Publication number: 20230333001Abstract: Systems and methods for flow cytometry. The methods comprise: labeling cells of a sample with Raman tags; causing the sample to flow through a microfluidic channel of a flow cytometer through which a laser beam passes; detecting Raman signals emitted from the Raman tags while being illuminated by the laser beam; and determining characteristics of the cells based on the detected Raman signals.Type: ApplicationFiled: April 19, 2022Publication date: October 19, 2023Inventors: Kotaro Hiramatsu, Ryo Nishiyama, Keisuke Goda, Kosuke Dodo, Shintaro Kawamura, Mikiko Sodeoka, Hideyusi Suzuki, Charlie Zhang, William Yang Terziyan
-
Patent number: 10995043Abstract: Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl) peroxide with a compound having a carbon-carbon unsaturated bond and/or an aromatic ring having a hydrogen atom bonded thereto in the presence of a copper catalyst.Type: GrantFiled: December 12, 2016Date of Patent: May 4, 2021Assignee: RikenInventors: Mikiko Sodeoka, Shintaro Kawamura
-
Patent number: 10823612Abstract: A multifocal spectrometric device is capable of simultaneously performing a measurement of a plurality of sample with high sensitivity, with no restriction on the magnification. A multifocal spectrometric device is a device in which beams of signal light emitted from a plurality of predetermined observation areas on samples placed in a sample placement section are introduced into a spectrograph and thereby dispersed into spectra, the device including: a plurality of objective lenses (objective light-condensing sections) individually located at positions which respectively and optically face the plurality of observation areas; and spectrograph input sections provided in such a manner that each of the plurality of objective lenses has one corresponding spectrograph input section, for introducing signal light passing through the corresponding objective lenses into the spectrograph.Type: GrantFiled: January 29, 2016Date of Patent: November 3, 2020Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Mikiko Sodeoka, Katsumasa Fujita, Jun Ando
-
Publication number: 20200277243Abstract: Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl) peroxide with a compound having a carbon-carbon unsaturated bond and/or an aromatic ring having a hydrogen atom bonded thereto in the presence of a copper catalyst.Type: ApplicationFiled: December 12, 2016Publication date: September 3, 2020Inventors: Mikiko Sodeoka, Shintaro Kawamura
-
Patent number: 10338078Abstract: The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.Type: GrantFiled: August 13, 2013Date of Patent: July 2, 2019Assignee: Japan Science and Technology AgencyInventors: Mikiko Sodeoka, Jun Ando, Miwako Asanuma, Kosuke Dodo, Katsumasa Fujita
-
Publication number: 20180136040Abstract: A multifocal spectrometric device is capable of simultaneously performing a measurement of a plurality of sample with high sensitivity, with no restriction on the magnification. A multifocal spectrometric device is a device in which beams of signal light emitted from a plurality of predetermined observation areas on samples placed in a sample placement section are introduced into a spectrograph and thereby dispersed into spectra, the device including: a plurality of objective lenses (objective light-condensing sections) individually located at positions which respectively and optically face the plurality of observation areas; and spectrograph input sections provided in such a manner that each of the plurality of objective lenses has one corresponding spectrograph input section, for introducing signal light passing through the corresponding objective lenses into the spectrograph.Type: ApplicationFiled: January 29, 2016Publication date: May 17, 2018Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Mikiko SODEOKA, Katsumasa FUJITA, Jun ANDO
-
Publication number: 20150192590Abstract: The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.Type: ApplicationFiled: August 13, 2013Publication date: July 9, 2015Applicant: Japan Science and Technology AgencyInventors: Mikiko SODEOKA, Jun ANDO, Miwako ASANUMA, Kosuke DODO, Katsumasa FUJITA
-
Patent number: 7351849Abstract: The present invention is to provide a method for producing the desired optically active ?-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for producing an optically active ?-amino acid derivative or a salt thereof represented by the formula (2): which comprises reacting an ?,?-unsaturated carboxylic acid derivative or a salt thereof represented by the formula (1): with an amines or a salt thereof in the presence of a chiral catalyst and in the presence or absence of an acid.Type: GrantFiled: August 18, 2004Date of Patent: April 1, 2008Assignee: Takasago International CorporationInventors: Mikiko Sodeoka, Yoshitaka Hamashima
-
Publication number: 20060205968Abstract: The present invention is to provide a method for producing the desired optically active ?-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for producing an optically active ?-amino acid derivative or a salt thereof represented by the formula (2): which comprises reacting an ?,?-unsaturated carboxylic acid derivative or a salt thereof represented by the formula (1): with an amines or a salt thereof in the presence of a chiral catalyst and in the presence or absence of an acid.Type: ApplicationFiled: August 18, 2004Publication date: September 14, 2006Inventors: Mikiko Sodeoka, Yoshitaka Hamashima
-
Patent number: 6589977Abstract: Bisindolylpyrrole derivatives represented by general formula [I] which are useful in inhibiting cell death and expected as being useful as preventives and remedies for the progress of various diseases in the progress and worsening of which cell death participates; and cell death inhibitors, drugs and cell/tissue/organ preservatives containing as the active ingredient these derivatives or pharmaceutically acceptable salts thereof.Type: GrantFiled: August 6, 2001Date of Patent: July 8, 2003Assignees: Sagami Chemical Research CenterInventors: Mikiko Sodeoka, Miho Katoh, Mikako Fujita, Rei Asakai
-
Publication number: 20030087949Abstract: The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exacerbation thereof: 1Type: ApplicationFiled: September 26, 2002Publication date: May 8, 2003Inventors: Mikiko Sodeoka, Miho Kato, Rei Asakai
-
Patent number: 5880301Abstract: The present invention provides a novel optically active bidentate phosphine ligand palladium complex of formula (I) or (II) which can be used for the preparation of optically active .beta.-hydroxyketones: ##STR1## ?wherein Y.sup.- represents an anion pair which may form salt; X represents ##STR2## {wherein R.sup.1 represents hydrogen atom, C.sub.1-6 alkyl group, C.sub.1-6 alkoxyl group, cyano group, nitro group, halogen atom or phenyl group, etc.; m represents 1 or 2; when m is 2, two R.sup.1 s may be same or different}; andA and B each independently represents phenyl group or cyclohexyl group {said phenyl group and cyclohexyl group each is unsubstituted or substituted by R.sup.2 (R.sup.2 has the same meaning as defined in R.sup.1)}).Type: GrantFiled: September 16, 1997Date of Patent: March 9, 1999Assignee: Nissan Chemical Industries, Ltd.Inventors: Masakatsu Shibasaki, Mikiko Sodeoka, Kazuhiko Ohrai
-
Patent number: 5053526Abstract: Disclosed is a pharmaceutical having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt of its salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group; A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or 1 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof, the asymmetric center in the substituent represented by A is R-configuration or S-configuration or a mixture thereof.Type: GrantFiled: April 16, 1990Date of Patent: October 1, 1991Assignees: Mitsubishi Kasei Corporation, Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Mikiko Sodeoka, Yuji Ogawa, Toshiaki Mase, Akira Ishibashi, Daijiro Horii, Toshiji Kanayama, Katsuhiko Iseki, Masaki Shinoda, Chiyoko Ishiyama, Yoshio Hayashi
-
Patent number: 4839388Abstract: This invention relates to a novel prostacyclin represented by the formula: ##STR1## [wherein R.sup.1 represents --CO.sub.2 R.sup.5 group or --CONR.sup.6 R.sup.7 group; A is(i) --CH.dbd.CH--CH.sub.2 CH.sub.2 -- or(ii) --CH.sub.2 CH.sub.2 --O--CH.sub.2 --;B represents --C.tbd.C-- group; R.sup.2 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a phenyl group or a phenoxy group;R.sup.3 represents a hydrogen atom, a methyl group or a vinyl group; R.sup.4 represents a hydrogen atom, an acyl group, a tri(1 to 7 carbon atoms)hydrocarbyl-silyl group or a group forming an acetal bond with an oxygen atom of a hydroxy group; a double bond in the substituent represented by A is E or Z, or a mixture thereof; asymmetric center in the substituent represented by R.sup.Type: GrantFiled: May 18, 1987Date of Patent: June 13, 1989Assignees: Mitsubishi Chemical Industries Limited, Sagami Chemical Research CenterInventors: Masakatsu Sibasaki, Mikiko Sodeoka, Katsuhiko Iseki, Masaki Shinoda, Chiyoko Aoki, Yosio Hayasi, Toshiji Kanayama
-
Patent number: 4777271Abstract: An isocarbacyclin derivative represented by the general formula ##STR1## wherein R.sup.1 represents a linear, branched or cyclic alkyl, alkenyl or alkynyl group having 5 to 10 carbon atoms, and R.sup.2 and R.sup.3 represent a hydrogen atom or a protective group for the hydroxyl group; and a process for production thereof.Type: GrantFiled: May 29, 1987Date of Patent: October 11, 1988Assignee: Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Mikiko Sodeoka, Toshiaki Mase
-
Patent number: 4774341Abstract: There are disclosed a bicyclo [3.3.0]octane derivative represented by the formula: ##STR1## wherein R.sup.1 is a substituent selected from the group consisting of a hydrogen atom and a protective group of a hydroxy group;R.sup.2 is a substituent selected from the group consisting of --CH.sub.2 OR.sup.5 and ##STR2## where R.sup.5 is a substituent selected from the group consisting of a hydrogen atom and a protective group of a hydroxy group,R.sup.6 is a substituent selected from the group consisting of an alkyl group, an alkenyl group and an alkynyl group, said substituent being straight, branched or cyclic and having 5 to 10 carbon atoms,X is a substituent selected from the group consisting of a vinylene group and an acetylene group, andR.sup.7 is a substituent selected from the group consisting of an alkyl group, an alkenyl group, and an alkynyl group said substituent being straight, branched or cyclic and having 5 to 10 carbon atoms; andR.sup.3 is a substituent represented by the formula --Y--(CH.sub.2).Type: GrantFiled: September 29, 1986Date of Patent: September 27, 1988Assignee: Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Mikiko Sodeoka, Yuji Ogawa
-
Patent number: 4762936Abstract: There are disclosed a bicyclo[3.3.0]octene derivatives having the following formula: ##STR1## wherein R.sup.1 : a straight, branched or cyclic alkyl group or alkenyl group each having 5 to 10 carbon atoms;R.sup.2 and R.sup.3 : each represent a hydrogen atom or a protective group of a hydroxy group; andR.sup.4 : --CH.dbd.CH--(CH.sub.2).sub.2 --COOR.sup.5 or --CH.sub.2 R.sup.6 ; whereR.sup.5 : a hydrogen atom or an alkyl group; andR.sup.6 : a hydroxy group, an acetyloxy group or a butenyl group,and process for producing the same. These compounds and the process for producing them are available for producing a 9(0)-methano-.DELTA..sup.6 (9.alpha.)-PGI.sub.1.Type: GrantFiled: December 11, 1986Date of Patent: August 9, 1988Assignee: Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Toshiaki Mase, Mikiko Sodeoka, Yuji Ogawa
-
Patent number: 4699921Abstract: Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Type: GrantFiled: August 8, 1985Date of Patent: October 13, 1987Assignees: Mitsubishi Yuka Pharmaceutical Co., Ltd., Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Mikiko Sodeoka, Yuji Ogawa, Toshiaki Mase, Akira Ishibashi, Daijiro Horii, Toshiji Kanayama, Katsuhiko Iseki, Masaki Shinoda, Chiyoko Ishiyama, Yoshio Hayashi
-
Patent number: 4681951Abstract: There are disclosed bicyclo[3.3.0]octene derivatives having the following formula: ##STR1## wherein R.sup.1 is a straight, branched or cyclic alkyl group or alkenyl group each having 5 to 10 carbon atoms; andR.sup.2 and R.sup.3 are each separately a hydrogen atom or a protective group of a hydroxy group,and process for producing the same. These compounds and the process for producing them are available for producing a 9(0)-methano-.DELTA.6(9.alpha.)-PGI.sub.1.Type: GrantFiled: August 17, 1984Date of Patent: July 21, 1987Assignee: Sagami Chemical Research CenterInventors: Masakatsu Shibasaki, Toshiaki Mase, Mikiko Sodeoka, Yuji Ogawa