Patents by Inventor Mikkel Nissum

Mikkel Nissum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9926344
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: March 27, 2018
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Fabio Bagnoli, Fabiana Falugi, Guido Grandi, Massimo Mariani, Mikkel Nissum, Michele Pallaoro, Silvana Savino
  • Publication number: 20150203543
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: July 23, 2015
    Inventors: Fabio Bagnoli, Fabiana Falugi, Guido Grandi, Massimo Mariani, Mikkel Nissum, Michele Pallaoro, Silvana Savino
  • Publication number: 20150203542
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: July 23, 2015
    Inventors: Fabio Bagnoli, Fabiana Falugi, Guido Grandi, Massimo Mariani, Mikkel Nissum, Michele Pallaoro, Silvana Savino
  • Publication number: 20150202277
    Abstract: Elimination of disulphide bond formation of cysteine-containing S.aureus antigens enhances antigen stability. The invention provides a composition comprising variant forms of cysteine-containing S.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: July 23, 2015
    Inventors: Fabio Bagnoli, Simone Bufali, Simona Cianetti, Anna Coslovi, Guido Grandi, Mikkel Nissum, Michele Pallaoro, Silvana Savino, Michele Sotgiu
  • Publication number: 20150191513
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: July 9, 2015
    Inventors: Fabio Bagnoli, Matthew Bottomley, Guido Grandi, Mikkel Nissum, Michele Pallaoro, Silvana Savino
  • Patent number: 8871527
    Abstract: The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone analog(s) thereof involved in diabetes or metabolic syndrome. The methods comprise a quantitative separation of at least those analytes of interest whose common presence interferes with measuring the presence/absence or concentration of one of the analytes of interest by a subsequent analytical method.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: October 28, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Mikkel Nissum, Christoph Eckerskorn, Andreas Pfuetzner, Thomas Forst
  • Patent number: 8449744
    Abstract: The invention relates to the use of MS compatible surfactants in free-flow electrophoretic methods, which allow the separation of analytes with differentiated electrophoretic mobility. The surfactant is preferably a cleavable surfactant, such as PPS.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: May 28, 2013
    Assignee: Becton, Dickinson and Company
    Inventor: Mikkel Nissum
  • Publication number: 20110177537
    Abstract: The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone analog(s) thereof involved in diabetes or metabolic syndrome. The methods comprise a quantitative separation of at least those analytes of interest whose common presence interferes with measuring the presence/absence or concentration of one of the analytes of interest by a subsequent analytical method.
    Type: Application
    Filed: April 29, 2009
    Publication date: July 21, 2011
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: Mikkel Nissum, Christoph Eckerskorn, Andreas Pfuetzner, Thomas Forst
  • Publication number: 20110097718
    Abstract: The invention relates to the use of MS compatible surfactants in free-flow electrophoretic methods, which allow the separation of analytes with differentiated electrophoretic mobility. The surfactant is preferably a cleavable surfactant, such as PPS.
    Type: Application
    Filed: November 12, 2008
    Publication date: April 28, 2011
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventor: Mikkel Nissum
  • Publication number: 20110005930
    Abstract: The present invention provides methods and separation media for separating analytes of interest via free flow electrophoresis (FFE) using volatile buffer systems. The separation media provided herein allow a convenient separation of the analytes by electrophoresis, and offer the additional advantage that the buffer compounds and the solvent can be easily and residue-free removed after the electrophoretic separation step. Furthermore, methods for mass spectrometric analysis of analytes comprising an FFE method and kits for carrying out FFE separations with volatile buffer systems are also provided. Preferably, the volatile buffer system is TRIS acetate.
    Type: Application
    Filed: June 20, 2008
    Publication date: January 13, 2011
    Inventors: Gerhard Weber, Mikkel Nissum, Gerhard Weber, Mikkel Nissum