Patents by Inventor Mikkel Thaning
Mikkel Thaning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10004816Abstract: The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.Type: GrantFiled: January 10, 2013Date of Patent: June 26, 2018Assignee: GE HEALTHCARE ASInventors: Ben Newton, Mikkel Thaning, Dirk-Jan in't Veld, Karina Langseth, Paul Michael Evans
-
Patent number: 9938233Abstract: The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast agents, such as Iodixanol and Ioforminol. More particularly, the invention relates to purification of such X-ray contrast agents using membrane technology to remove monomeric impurities.Type: GrantFiled: November 19, 2013Date of Patent: April 10, 2018Assignee: GE Healthcare ASInventors: Jan Cervenka, Mikkel Thaning, Andreas Olsson, Christian Glogard
-
Patent number: 9827334Abstract: The present invention relates to a process for the preparation of Ioforminol, a contrast agent useful in X-ray imaging. More particularly, the invention relates to preparation of Ioforminol from a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene by a process comprising in situ hydrolysis and a bis-alkylation.Type: GrantFiled: September 17, 2013Date of Patent: November 28, 2017Assignee: GE Healthcare ASInventors: Mikkel Thaning, Andreas Olsson, Christian Glogard
-
Patent number: 9738596Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: GrantFiled: December 12, 2014Date of Patent: August 22, 2017Assignee: GE Healthcare ASInventor: Mikkel Thaning
-
Publication number: 20160304440Abstract: The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast agents, such as Iodixanol and Ioforminol. More particularly, the invention relates to purification of such X-ray contrast agents using membrane technology to remove monomeric impurities.Type: ApplicationFiled: November 19, 2013Publication date: October 20, 2016Inventors: Jan Cervenka, Mikkel Thaning, Andreas Olsson, Christian Glogard
-
Patent number: 9272056Abstract: The invention relates to a dynamic nuclear polarisation method for producing hyperpolarised carboxylates of organic amines and amino compounds and compositions for use in that method. The DNP agent preferably is a stable oxygen-based, sulphur-based or carbon-based trityl radical. Optionally a paramagnetic metal ion is present.Type: GrantFiled: December 15, 2006Date of Patent: March 1, 2016Assignee: GE Healthcare ASInventors: Mikkel Thaning, Karl Andreas Gram
-
Publication number: 20150265727Abstract: The present invention relates to a process for the preparation of Ioforminol, a contrast agent useful in X-ray imaging. More particularly, the invention relates to preparation of Ioforminol from a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene by a process comprising in situ hydrolysis and a bis-alkylation.Type: ApplicationFiled: September 17, 2013Publication date: September 24, 2015Inventors: Mikkel Thaning, Andreas Olsson, Christian Glogard
-
Publication number: 20150246871Abstract: The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. More particularly, the invention relates to a work-up process for preparation of a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene, a key intermediate in the process for preparing Ioforminol. Further, the invention relates to a process for preparing Ioforminol, a contrast agent useful in X-ray imaging.Type: ApplicationFiled: September 17, 2013Publication date: September 3, 2015Applicant: GE Healthcare ASInventors: Mikkel Thaning, Andreas Olsson, Christian Glogard
-
Publication number: 20150191422Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: ApplicationFiled: December 12, 2014Publication date: July 9, 2015Applicant: GE HEALTHCARE ASInventor: MIKKEL THANING
-
Publication number: 20150190533Abstract: The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.Type: ApplicationFiled: January 10, 2013Publication date: July 9, 2015Applicant: GE HEALTHCARE ASInventors: Ben Newton, Mikkel Thaning, Dirk-Jan in't Veld, Karina Langseth, Paul Michael Evans
-
Patent number: 9023320Abstract: The invention relates to a method of producing a composition comprising hyperpolarised 13C-pyruvate, the composition and its use as an imaging agent for MR imaging.Type: GrantFiled: July 28, 2005Date of Patent: May 5, 2015Assignee: GE Healthcare ASInventor: Mikkel Thaning
-
Patent number: 8980224Abstract: The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.Type: GrantFiled: November 18, 2005Date of Patent: March 17, 2015Assignee: GE Healthcare ASInventors: Mathilde Lerche, Rene Zandt, Klaes Golman, Mikkel Thaning, Jan-Henrik Ardenkjaer-Larsen, Stefan Petersson
-
Patent number: 8951502Abstract: The invention relates to a method of dynamic nuclear polarisation (DNP) using a combination of a trityl radical and a paramagnetic metal ion as the polarising agent leading to enhanced levels of polarisation in the sample to be polarised and to compositions and polarising agents for use in the method.Type: GrantFiled: December 1, 2006Date of Patent: February 10, 2015Assignee: GE Healthcare ASInventors: Mikkel Thaning, Rolf Servin
-
Patent number: 8920780Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: GrantFiled: July 4, 2008Date of Patent: December 30, 2014Assignee: GE Healthcare ASInventor: Mikkel Thaning
-
Publication number: 20140322139Abstract: The invention relates to a composition comprising a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier, and particularly to a supersaturated X-ray composition comprising X-ray contrast agents with a high dissolution temperature in water. Particularly, the invention provides such composition which is stable, and wherein crystallisation during storage is avoided. In a preferred aspect the X-ray contrast agent is Ioforminol and the composition includes a nucleation- and growth inhibitor. The invention further relates to a process for the preparation of such stable diagnostic X-ray composition.Type: ApplicationFiled: December 20, 2012Publication date: October 30, 2014Applicant: GE HEALTHCARE ASInventors: Christian Glogard, Mikkel Thaning, Jan Cervenka
-
Patent number: 8815210Abstract: The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.Type: GrantFiled: October 28, 2010Date of Patent: August 26, 2014Assignee: GE Healthcare ASInventors: Lars-Göran Wistrand, Mikkel Thaning, Ben Newton
-
Patent number: 8633337Abstract: The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives.Type: GrantFiled: May 13, 2011Date of Patent: January 21, 2014Assignee: GE Healthcare LimitedInventors: Anders Brathe, Andreas Olsson, Mikkel Thaning, Steffen Bugge
-
Patent number: 8431723Abstract: The invention relates to new radicals, their use as paramagnetic agents in a method for the dynamic nuclear polarisation and a method for the dynamic nuclear polarisation of compounds comprising carboxyl groups.Type: GrantFiled: July 28, 2005Date of Patent: April 30, 2013Assignee: GE Healthcare ASInventor: Mikkel Thaning
-
Publication number: 20130060064Abstract: The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives.Type: ApplicationFiled: May 13, 2011Publication date: March 7, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Anders Brathe, Andreas Olsson, Mikkel Thaning, Steffen Bugge
-
Publication number: 20120328522Abstract: The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.Type: ApplicationFiled: October 28, 2010Publication date: December 27, 2012Inventors: Lars-Göran Wistrand, Mikkel Thaning, Ben Newton