Patents by Inventor Mikko Mäkelä
Mikko Mäkelä has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240158377Abstract: The present invention relates to novel salts, particularly crystalline salts, of 2-(isoindolin-2-ylmethyl)-5-((1-(methyl sulfonyl)piperidin-4-yl)methoxy)-4H-pyran-4-one (I) which are particularly suitable for use in the manufacture of pharmaceutical 5 compositions. Furthermore, the invention relates to pharmaceutical compositions comprising such novel salts. Compound (I) is a selective inhibitor of CYP11A1 enzyme and is useful in the treatment of hormonally regulated cancers, such as prostate cancer and breast cancer.Type: ApplicationFiled: February 28, 2022Publication date: May 16, 2024Applicant: Orion CorporationInventors: Oskari Karjalainen, Mikko Mäkelä, Mihaela Pop, Petteri Rummakko, Anna Shevchenko, Kai Sinervo, Eija Tiainen
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Publication number: 20240158378Abstract: The present invention relates to novel solid forms, particularly crystalline forms, of 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4H-pyran-4-one (I). Compound (I) is a selective inhibitor of CYP11A1 enzyme and is useful in the treatment of hormonally regulated cancers, such as prostate cancer and breast cancer.Type: ApplicationFiled: February 28, 2022Publication date: May 16, 2024Applicant: Orion CorporationInventors: Oskari Karjalainen, Mikko Mäkelä, Mihaela Pop, Anna Shevchenko, Eija Tiainen
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Publication number: 20230192677Abstract: The present invention relates to compounds of formula (I) and (II) and pharmaceutically acceptable salts thereof. The compounds of formula (I) or (II) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: ApplicationFiled: May 12, 2021Publication date: June 22, 2023Inventors: David DIN BELLE, Esa KUMPULAINEN, Mikko MÄKELÄ, Pekka PIETIKÄINEN, Shouming WANG, Gerd WOHLFAHRT
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Patent number: 11352346Abstract: The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.Type: GrantFiled: November 30, 2018Date of Patent: June 7, 2022Assignee: ORION CORPORATIONInventors: Ilpo Laitinen, Mikko Leskinen, Mikko Mäkelä
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Publication number: 20210347765Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: ApplicationFiled: July 6, 2021Publication date: November 11, 2021Inventors: David DIN BELLE, Mikko Mäkelä, Mikko Passiniemi, Pekka Pietikäinen, Petteri Rummakko, Eija Tiainen, Matti Vaismaa, Gerd Wohlfahrt
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Patent number: 11098032Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: GrantFiled: June 8, 2020Date of Patent: August 24, 2021Assignee: ORION CORPORATIONInventors: David Din Belle, Mikko Mäkelä, Mikko Passiniemi, Pekka Pietikäinen, Petteri Rummakko, Eija Tiainen, Matti Vaismaa, Gerd Wohlfahrt
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Publication number: 20200308152Abstract: The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.Type: ApplicationFiled: November 30, 2018Publication date: October 1, 2020Inventors: Ilpo LAITINEN, Mikko LESKINEN, Mikko MÄKELÄ
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Publication number: 20200299280Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: ApplicationFiled: June 8, 2020Publication date: September 24, 2020Inventors: David DIN BELLE, Mikko MÄKELÄ, Mikko PASSINIEMI, Pekka PIETIKÄINEN, Petteri RUMMAKKO, Eija TIAINEN, Matti VAISMAA, Gerd WOHLFAHRT
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Patent number: 10717726Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: GrantFiled: December 21, 2017Date of Patent: July 21, 2020Assignee: ORION CORPORATIONInventors: David Din Belle, Mikko Mäkelä, Mikko Passiniemi, Pekka Pietikäinen, Petteri Rummakko, Eija Tiainen, Matti Vaismaa, Gerd Wohlfahrt
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Publication number: 20190359601Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.Type: ApplicationFiled: December 21, 2017Publication date: November 28, 2019Inventors: David DIN BELLE, Mikko MÄKELÄ, Mikko PASSINIEMI, Pekka PIETIKÄINEN, Petteri RUMMAKKO, Eija TIAINEN, Matti VAISMAA, Gerd WOHLFAHRT
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Patent number: 9249127Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.Type: GrantFiled: March 28, 2013Date of Patent: February 2, 2016Assignee: ORION CORPORATIONInventors: Tuula Koskelainen, Tero Linnanen, Anna Minkkilä, Mikko Mäkelä, Antti Pohjakallio
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Publication number: 20150065550Abstract: Compounds of formula (I), wherein X and R1-R6, are as defined in the claims, exhibit alpha2 agonistic activity and thus are useful as alpha2 agonists, especially as alpha2A agonists. Methods of use of said compounds are also provided.Type: ApplicationFiled: March 28, 2013Publication date: March 5, 2015Inventors: Tuula Koskelainen, Tero Linnanen, Anna Minkkilä, Mikko Mäkelä, Antti Pohjakallio
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Patent number: 8745515Abstract: This invention relates to method for presenting at least a part of a page, comprising at least partially dividing at least one page into a plurality of areas, presenting said plurality of areas in a first representation, making at least one area of said plurality of areas an active area, and in response to a user operation on said at least one active area, presenting at least one of said at least one active areas in a second representation. Said at least one page may be a Hypertext Markup Language HTML page, or a page of a text document, and said display may be integrated in a portable electronic device. The invention further relates to a device, a system, a computer program and a computer program product.Type: GrantFiled: April 7, 2004Date of Patent: June 3, 2014Assignee: Nokia CorporationInventor: Mikko Mäkelä
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Patent number: 8472329Abstract: The invention relates to network connection management, wherein user confirmations are queried for implementing operations requiring a network connection. According to the invention the user confirmation are queried variantly depending on the initiator of the operation. The invention relates to a devices for browsing the network and to a computer program product.Type: GrantFiled: May 3, 2004Date of Patent: June 25, 2013Assignee: Nokia CorporationInventor: Mikko Mäkelä
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Patent number: 8108208Abstract: The invention relates to a method and an apparatus of requesting a service from a communications network. In the method the following steps are to performed: generating an objective statement in a user equipment; communicating the objective statement from the user equipment to a mediator unit; comparing the objective statement to a list of objective statements in the mediator unit; establishing the service based at least partly on the comparison; and providing the service to the user of the user equipment.Type: GrantFiled: February 24, 2005Date of Patent: January 31, 2012Assignee: Saimaan IPR OyInventor: Mikko Mäkelä
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Patent number: 7594194Abstract: The invention relates to a method, a device, a computer program product, a browser and a network element for improved portrayal of navigation objects (1-1 . . . 1-6), wherein at least two navigation objects (1-1 . . . 1-6) are combined into one combined navigation object (4), wherein said combined navigation object (4) is presented, and wherein said at least two navigation objects (1-1 . . . 1-6) are presented, if said combined navigation object (4) is selected.Type: GrantFiled: September 24, 2003Date of Patent: September 22, 2009Assignee: Nokia CorporationInventor: Mikko Mäkelä
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Patent number: 7581174Abstract: In the method for displaying a web page, a web page received from a server and comprising a frameset is displayed in the browser window of a terminal in such a manner that the frameset is converted into a different format. In the method, the frameset is converted into a table (T), in which case each frame (F1, F2) is converted into a corresponding cell (TD1, TD2) of the table (T). The formed table (T) is then displayed in said browser window (D2). The invention also relates to a conversion method, as well as to a converting unit and a computer software for implementing this conversion method. In addition, the invention relates to a system, as well as to a terminal (MS).Type: GrantFiled: January 21, 2005Date of Patent: August 25, 2009Assignee: Nokia CorporationInventor: Mikko Mäkelä
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Patent number: 7565604Abstract: A method for displaying information in a device (1), which information is stored as a document with interpreting instructions for displaying the information. The interpreting instructions are interpreted, and on the basis of the interpretation, the information is converted to information to be displayed on the display of the device. In connection with the conversion of the document, it is examined if the document can be displayed without optimization on the display (2) of the device, wherein if, on the basis of the examination, it is detected that the displaying of the document requires optimization, the document is optimized; in other cases, the document is displayed in unoptimized format. The invention also relates to a system and a device (1) applying the method.Type: GrantFiled: June 25, 2004Date of Patent: July 21, 2009Assignee: Nokia CorporationInventor: Mikko Mäkelä
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Patent number: 7509575Abstract: The invention relates to an optimization of digital content being presented on the display. In a method for optimizing content, the content is analyzed and at least one sequence element is determined. According to this sequence element, said content is portioned into at least two portions, whereby an operation for at least one portion is performed. Also, a control element is provided for at least one other portion.Type: GrantFiled: March 30, 2005Date of Patent: March 24, 2009Assignee: Nokia CorporationInventor: Mikko Mäkelä